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Fa'amatalaga:monoammonium glycyrrhizinate hydrate o loʻo iai gaioiga faʻafomaʻi e pei o le anti-inflammatory, anti allergic, anti gastric ulcer ma anti hepatitis.

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I Vivo Suesuega:o le fa'atuputeleina o le mama w/D fua faatatau mamafa na matua fa'aititia e ala i le fa'atonuina o fua maualuga ma feololo o mag (10 ma le 30 mg / kg).Pretreatment ma mag (10 ma 30 mg / kg) lelei faaitiitia TNF- α Ma IL-1 β Tupulaga o.Mag (10,30 mg / kg) faʻaititia tele le NF faʻatusatusa i le LPS- κ Bp65 faʻamatalaga porotini.I se faʻatusatusaga, o le LPS na faʻaititia tele I pe a faʻatusatusa i le vaega faʻatonutonu κ B-α Protein expression, aʻo mag (10 ma 30 mg / kg) faʻateleina le faʻaalia I κ B-α Expression [1].Faʻatusatusa i vaega RIF ma INH, maualalo-dose ma maualuga-dose MAG togafitiga faʻaititia tele ast, alt, TBIL ma TBA maualuga i 14 ma 21 aso, e faʻaalia ai le puipuiga o le MAG i le RIF - ma le INH -.Fa'aoso manu'a ate.MAG togafitiga vaega faateleina le ate GSH maualuga i 7, 14 ma 21 aso, ma matua faaitiitia MDA tulaga i 14 ma 21 aso i RIF ma INH togafitia isumu, e faailoa ai le aafiaga puipuia o MAG i RIF - ma.INH fa'aoso manu'a ate [2].

Fa'ata'ita'iga i Manu:isumu [1] i lenei suʻesuʻega, BALB / c isumu (tane, 6-8 vaiaso le matua, 20-25g) sa faʻaaogaina.O isumu na vaevaeina faʻafuaseʻi i vaega e 5: vaega faʻatonutonu, vaega LPS ma le LPS + monoammonium glycyrrhizinate (Mag: 3,10 ma le 30mg / kg).O vaega ta'itasi e 8 isumu.O isumu na fa'ama'i ile tui intraperitoneal ole pentobarbital sodium (50 mg/kg).O isumu na tui ile intraperitoneally ile mag (3, 10 ma le 30 mg / kg) aʻo leʻi faʻaosoina manuʻa tuga o le mama.A maeʻa le 1 itula, LPS (5 mg / kg) na tui ile intratracheal e faʻaoso ai manuʻa tuga o le mama.O isumu masani na tuʻuina atu i ai le PBS [1].Iole [2] na fa'aaogaina tama'i iole Wistar (180-220g).O isumu na vaevaeina faʻafuaseʻi i vaega 4: vaega faʻatonutonu, RIF ma INH vaega, MAG maualalo-dose vaega ma MAG maualuga-dose vaega, ma 15 isumu i vaega taitasi.O isumu i vaega RIF ma INH na tuʻuina atu i ai le RIF (60mg / kg) ma le INH (60mg / kg) e ala i le gavage faʻatasi i le aso;O isumu i le vaega MAG na muamua togafitia i le MAG i le fua o le 45 poʻo le 90 mg / kg, ma le RIF (60 mg / kg) ma le INH (60 mg / kg) na tuʻuina atu i le 3 itula ina ua maeʻa le pulega MAG;O isumu i le vaega faʻatonutonu sa togafitia i le saline masani.Ina ia mafai ona iloilo le malosi o le aʻafiaga o le vailaʻau, o isumu i vaega taʻitasi na fasiotia 7, 14 ma 21 aso talu ona faʻatonuina [2].

Fa'asinomaga:1].Huang X, et al.A'afiaga Fa'aleaga o le Monoammonium Glycyrrhizinate i luga ole Lipopolysaccharide-Induced Acute Mama Manu'a i isumu e ala ile fa'atonutonuina ole Nuclear Factor-Kappa B Alaala Fa'ailoga.Evid Based Complement Alternat Med.2015;2015:272474.
[2].Zhou L, ma isi.Monoammonium glycyrrhizinate puipuia le rifampicin- ma le isoniazid-fa'aoso le hepatotoxicity e ala i le faʻatonutonuina o le faʻaaliga o le transporter Mrp2, Ntcp, ma Oatp1a4 i le ate.Pharm Biol.2016;54(6):931-7.