Cycloastragenol CAS Numera 78574-94-4
Fa'amatalaga o oloa
[igoa]:cycloastragalus ava malosi
[alias]:triterpenoid cyclic flavonol
[Igoa Igilisi]:cycloastragenol
[fua mole mole]:C30H50O5
[mamafa molekalale]:490.71
[CAS Nu.]:78574-94-4
[auala e iloa ai]:HPLC ≥ 98%
[Fa'amatalaga]:20mg 50mg 100mg 500mg 1g (e mafai ona afifiina e tusa ai ma manaoga o tagata faatau)
[meatotino]:o lenei oloa e le lanu tioata acicular
[gaioiga ma faʻaoga]:O lenei oloa e faʻaaogaina mo le faʻamautuina o mea, faʻamaonia, faʻataʻitaʻiga vailaʻau, suʻega gaioiga ma isi suʻesuʻega suʻesuʻega faasaienisi.E pei o le cell administration, intragastric test, inspection quality inspection of pharmaceutical factory, etc.Source: Astragalus membranaceus (Fisch.) Bge.Fa'amamago a'a
Metotia Teuina
2-8 ° C, faʻamaufaʻailogaina mai le malamalama ma teuina i le vevela maualalo.
Manatua
O lenei oloa e tatau ona teuina i le maualalo o le vevela.Afai e faʻaalia i le ea mo se taimi umi, o le a faʻaitiitia le anotusi.
Tulaga chromatographic} koluma chromatographic: Zorbax rx-c18 (4.6mm) × 150mm),5 μm; Vaega feavea'i: vai acetonitrile (30:70);Fuafuaga tafe: 1.0ml / min, vevela koluma: 35 ℃, ELSD tapulaʻa: vevela paipa tafetafea: 105 ℃, fua faatatau tafe nitrogen: 2.70ml/min.
Amioga fa'aletino: mafiafia 1.20
Bioactivity o le cycloastragenol
Cycloastragalol o se triterpene saponin compound, o le Astragalus membranaceus (Fisch.) O le hydrolyzate o le mea galue malosi i Bunge).Astramembrangenin o loʻo i ai le saogalemu o le tautala ma e iai le tele o aʻafiaga faʻafomaʻi, e aofia ai le telomerase activation, telomere prolongation, anti-inflammatory and antioxidant properties.Astramembrangenin o loʻo iai ni mea e faʻafefe ai le matua.O le CAG e fa'aosofia ai le telomerase i totonu o keratinocytes fou a tagata ma sela neura o isumu ma fa'aosofia ai le fa'agaoioia o le CREB.Astramembrangenin e mafai ona i ai se togafitiga fou i le atuatuvale
Vaega talafeagai:
Ala fa'ailoga > > apoptosis > > apoptosis
Vaega su'esu'e > > fula / puipuiga
Ma'i su'esu'e >> ma'i neura
Su'esu'ega In Vitro:
Pe a faʻatusatusa i le faʻatautaia o le vaʻavaʻa i le aganuu HEK, o le protein membrane star (0-10 μ M; 3-6 aso) faʻateleina le tuputupu aʻe o le sela [1].Astramembrangenin(0.3 μM;5-90 minute) faʻaosoina le CREB phosphorylation i le cortical neurons muamua, ma o le faʻamatalaga o le CREB atoa i ituaiga uma e lua e leʻi aʻafia e CAG [1].Polotini fetū membrane (3) μ M;6-48 itula) e mafai ona faʻalauteleina i le vivo faʻaliliuina faʻailoga i neu, faʻateleina le faʻamatalaga TERT mRNA, ma faʻaalia le faʻateleina o le bcl 2 mRNA faʻamatalaga [1].Su'esu'ega fa'aolaola sela [1] laina fa'aola: HEK cell concentration: 1 μ M，3 μ M，10 μ M taimi fa'aleaganu'u: 3-6 aso i'uga: fa'aluaina le tuputupu a'e o sela ile 6 aso.Su'esu'ega blot i Sisifo [1] laina sela: fa'atonuga o sela o le neuron: 0.3 μ M taimi fa'aleaganu'u: 5 minute, 15 minute, 30 minute, 90 minute.I'uga: CAG fa'aosoina le CREB fa'agaoioia i neu.RT-PCR [1] laina sela: faʻaogaina o le neuron cell: 3 μ M taimi faʻaleaganuʻu: 6-48 itula iʻuga: faʻateleina le faʻaaliga o TERT ma Bcl 2 mRNA.
Fa'asinomaga:
[1].Ip FC, ma isi.Cycloastragenol o se telomerase activator malosi i sela neuronal: aʻafiaga mo le puleaina o le atuatuvale.Neurosignals.2014;22(1):52-63.
[2].Yu Y, et al.Cycloastragenol: O se sui fou fiafia mo faʻamaʻi e fesoʻotaʻi ma tausaga.Exp Ther Med.2018 Setema;16(3):2175-2182.
[3].Sun C, ma isi.O le Cycloastragenol e faʻasalalau le faʻagaoioia ma le faʻateleina o le taofiofia i le concanavalin A-faʻaosoina le faʻataʻitaʻiga o le lymphocyte pan-activation model.Immunopharmacol Immunotoxicol.2017 Iuni;39(3):131-139.
Meatotino Physicochemical O le Cycloastragenol
Malosi:1.2 ± 0.1 g / cm3
Mea fa'apuna:617.2 ± 55.0 ° C ile 760 mmHg
Mea e liusuavai ai:241.0 i le 245.0 ° C
fua mole:c30h50o5
mamafa mole:490.715
Fa'ailoga moli:327.1 ± 31.5 ° C
mamafa sa'o:490.365814
PSA:90.15000
LogP:3.82
Omiga ausa:0.0 ± 4.0 mmHg ile 25°C
Fa'ailoga su'esu'e:1.582
Cycloastragenol Fa'amatalaga Saogalemu
Fa'ailoga o felauaiga o oloa mata'utia: nonh mo auala uma o felauaiga
Numera RTECS;GX8265000
Fa'ailoga Tiute: 2942000000
Tiute a le Cycloastragalol
Fa'ailoga Tiute: 2942000000
Cycloastragalol Literature
Cycloastragenol o se telomerase activator malosi i sela neuronal: aʻafiaga mo le puleaina o le atuatuvale.
Neurosignals 22(1), 52-63, (2014)
Cycloastragenol (CAG) ole aglycone ole astragaloside IV.Na fa'ailoa muamua ina ua su'esu'eina fa'amatalaga a le Astragalus membranaceus mo mea fa'agaioiga ma mea fa'aantitua.O le suʻesuʻega nei ...
O se tala fou telomerase activator e taofiofia le faaleagaina o le mama i se faʻataʻitaʻiga o le idiopathic pulmonary fibrosis.
PLoS TASI 8(3) , e58423, (2013)
O le alia'e mai o fa'ama'i e feso'ota'i ma le telomere fa'aletonu, e aofia ai le AIDS, aplastic anemia ma pulmonary fibrosis, ua fa'amalosia ai le fiafia i telomerase activators.Matou te lipotia le faailoaina o se n...
Telomerase-faʻavaeina faʻafomaʻi faʻaleleia o le antiviral galuega a tagata CD8 + T lymphocytes.
J. Immunol.181(10), 7400-6, (2008)
Telomerase reverse e fa'aliliu ai le telomere DNA i pito o chromosomes laina ma fa'ate'a ai le matua.E ese mai i le tele o sela somatic masani, e itiiti pe leai foi ni gaioiga telomerase, immun...
Faa-Peretania Alias o Cycloastragalol
9,19-Cyclolanostane-3,6,16,25-tetrol,20,24-epoxy-,(3β,6α,9β,16β,20R,24S)-
Astramembrangenin
(3β,6α,9β,16β,20R,24R)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol
19-Cyclolanostane-3,6,16,25-tetrol,20,24-epoxy-,(3β,6α,9β,16β,20R,24R)-
(3β,6α,9β,16β,20R,24S)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol
Cyclosieversigenin
Cyclogalegigenin
