Dimethylfraxetin ;6,7,8-Trimethoxycoumarin
Fa'amatalaga o oloa
Igoa masani:elemene laau lefulefu
Numera CAS:6035-49-0
Malosi:1.2 ± 0.1 g / cm3
Fuafua mole:C12H12O5
MSDS:N / A
Igoa Igilisi:dimethylfraxetin
Molecular Weight:236.221
Fa'apuna:408.0 ± 45.0 ° C ile 760 mmHg
Lisi Lisi:104-105ºC
Mata'imu:184.3 ± 28.8 ° C
Gaioiga olaola o le dimethylfraxetin
Fa'amatalaga:O le dimethylfraxetin o se iniseti carbonic anhydrase ma le tau Ki o le 0.0097 μM.
Vaega Fa'atatau:
ala faailo > > metabolic enzyme / protease > > carbonic anhydrase
Su'esu'ega > > kanesa
Oloa Faanatura > > benzoic acids
Sini:ki: 0.0097 μ M (Carbonic anhydrase)[1]
Suʻesuʻega in vitro:i le CA I, o le tasi faʻalapotopotoga faʻapitoa o le dimethylfluoxetine (compound 17), o le nanomolar CA I inhibitor.O lenei trimethoxycoumarin e sili ona aoga o soʻo se NP coumarin i totonu ole ono CA isozymes i lenei suʻesuʻega [1].
Kinase:Aʻo leʻi faia se faʻamoemoega, o le inhibitor (e aofia ai le dimethylerythromycin) ma le enzyme solution na faʻapipiʻiina i le vevela o le potu mo le 6 itula e faʻatagaina ai le faʻavaeina o le enzyme inhibitor complex [1]
Fa'asinomaga:[1] Davis RA, et al.Coumarins oloa faanatura e taofia ai le carbonic anhydrases a le tagata.Bioorg Med Chem.2013 Mati 15;21(6):1539-43.
Dimethylfraxetin
Malosi:1.2 ± 0.1 g / cm3
Fa'apuna:408.0 ± 45.0 ° C ile 760 mmHg
Lisi Lisi:104-105ºC
Fuafua mole:c12h12o5
Molecular Weight:236.221
Mata'imu:184.3 ± 28.8 ° C
Mass sa'o:236.068466
PSA:57.90000
LogP:1.75
Malosi ausa:0.0 ± 1.0 mmHg ile 25°C
Fa'ailoga su'esu'e:1.545
Dimethylfraxetin Fa'amatalaga Saogalemu
Fa'amatalaga o tulaga lamatia (Europa): 22
Fa'amatalaga Saogalemu (Europa):22-45
Tulafono o le Tiute:293220990
Dimethylfraxetin Upstream ma lalo oloa oloa
DDimethylfraxetin Upstream Products
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Dimethylfraxetin Tiute
Tulafono o le Tiute:293220990
Va'aiga fa'aSaina:293220990 Isi lactones fua faatatau o le VAT: 17.0% Lafoga toe totogi: 13.0% Tulaga fa'atulafonoina: leai se MFN tau: 6.5% Totogi lautele: 20.0%
Elemene ta'utinoga:igoa o oloa, fatuga, anotusi ma faamoemoega
Aotelega:2932209090. isi lactones.VAT:17.0%.Lafoga fa'aitiitiga fua faatatau:13.0%..MFN tau:6.5%.Totogi lautele:20.0%
Fa'aigoa Igilisi ole Dimethylfraxetin
6,7,8-trimethoxychromen-2-tasi
6,7,8-Trimethoxy-2H-chromen-2-tasi
2H-1-Benzopyran-2-tasi, 6,7,8-trimethoxy-
