Neohesperidin
Fa'aaogāina ole Synephrine Hydrochloride
Neohesperidin o se ituaiga o flavonoid faʻapipiʻi o loʻo i ai lautele i laʻau Cucurbitaceae ma e iai aʻafiaga faʻamaʻi ma faʻamaʻi./h2>
Igoa o Neohesperidin
Igoa Igilisi: neohesperidin
Fa'aigoa Saina: neohesperidin |neohesperidin
Bioactivity o Neohesperidin
Fa'amatalaga: o le neohesperidin o se vaila'au flavonoid o lo'o maua i Cucurbitaceae, o lo'o iai a'afiaga fa'ama'i ma fa'ama'i.
Vaega fa'atatau: ala fa'ailoga > > isi > > isi
matā'upu su'esu'e > > fula / fa'ama'i
Oloa faanatura > > flavonoids
Su'esu'ega In Vitro:
New hesperidin fa'aoso apoptosis i le kanesa o le susu o le tagata MDA-MB-231 sela.O tau IC50 o neohesperidin i 24 ma 48 itula o 47.4 ± 2.6, faasologa μ M ma 32.5 ± 1.8 μ M. O le faʻamatalaga o le p53 ma le Bax na matua faʻatulafonoina i sela na togafitia neohesperidin, aʻo faʻaalia le Bcl-2 i lalo. fa'atulafonoina [1].Na faʻaalia e Neohesperidin le gaioiga faʻamalosi i le suʻega faʻamaʻi faʻamalosi a le DPPH (IC50 = 22.31 μg / mL) [2].
I Vivo Suʻesuʻega: neohesperidin (50mg / kg) faʻalavelave tele 55.0% HCl / ethanol faʻaoso manuʻa gatric.I le pylorus ligated rats, neohesperidin (50 mg / kg) na matua faʻaitiitia ai le manava o le manava ma le gaosiga o le gatric acid ma faʻateleina le pH [1].Neohesperidin togafitiga fa'aitiitia le anapogi toto kulukose, toto kulukose ma glycosylated serum porotini (GSP) i isumu.Na matua fa'atuputeleina ai le fa'apalepale o le kulukose gutu ma le ma'ale'ale o le inisalini, ma fa'aitiitia ai le fa'atosina o le inisalini i isumu suka.O le Neohesperidin na matua faʻaitiitia ai le triglycerides o le toto, cholesterol atoa, maualuga o le leptin ma le faʻasino o le ate i isumu [3].
Fa'ata'ita'iga a Manu: isumu: O isumu uma na anapopogi i le 6 itula a'o le'i faia le su'ega, ona fafaga lea i le vai po'o le neohesperidin e ala i le fafagaina fa'amalosi.Mo le OGTT ma le ITT, o isumu na tui ile intraperitoneally ile 2G / kg BW glucose poʻo le 1iu / kg BW insulin, i le faasologa.O fa'ata'ita'iga toto na aoina mai le vein caudal e fua ai le maualuga ole kulukose o le toto (0 minute) a'o le'i tuiina le kulukose po'o le inisalini.Na fuaina le maualuga ole kulukose ole toto ile 30, 60, 90 ma le 120 minute [3].
Fa'amatalaga:[1].Lee JH, ma isi.Aafiaga puipuia o neohesperidin ma poncirin vavae ese mai fua o le Poncirus trifoliata i maʻi gasegase e ono mafai.Phytother Res.2009 Tes;23(12):1748-53.
[2].Xu F, ma isi.Neohesperidin faʻaosoina apoptosis cellular i le susu o le tagata adenocarcinoma MDA-MB-231 sela e ala i le faʻagaoioia o le Bcl-2 / Bax-mediated ala faʻailoga.Nat Prod Commun.2012 Nov;7(11):1475-8.
[3].Jia S, et al.A'afiaga o le hypoglycemic ma le hypolipidemic o le neohesperidin e maua mai i le Citrus aurantium L. i le ma'isuka KK-A(y) isumu.Galuega Taumafa.2015 Mati;6(3):878-86.
Meatotino Physicochemical O Neohesperidin
Malosi: 1.7 ± 0.1 g / cm3
Fa'apuna: 933.7 ± 65.0 ° C ile 760 mmHg
Lisi Lisi: 239-243º C
Fuafuaga mole: C28H34O15
Molecular Weight: 610.561
Fa'asao: 306.7 ± 27.8 ° C
Misasa'o: 610.189758
PSA:234.29000
LogP:2.44
Fa'aaliga: 0.0 ± 0.3 mmHg ile 25 ° C
O'omiga ausa: 0.0 ± 0.3 mmHg ile 25°C
Fa'asino Upu: 1.695
Tulaga Teuina: 2-8 ° C
Fa'amatalaga Saogalemu Fou Hesperidin
Mea e puipui ai le tagata lava ia: talipupuni mata;Totini lima;ituaiga N95 (US);ituaiga P1 (EN143) faamama manava
Fa'amatalaga Saogalemu (Europa): s22-s24 / 25
Fa'ailoga o felauaiga o oloa mata'utia: nonh mo auala uma o felauaiga
Wgk Siamani: 3
RTECS Numera: dj2981400
Neohesperidin Literature
Faatusatusa metabolic ma transcriptional auiliiliga o se diploid faaluaina ma lona diploid citrus rootstock (C. junos cv. Ziyang xiangcheng) o loʻo fautua mai ai lona aoga aoga mo le faʻaleleia atili o le faʻalavelave.
BMC Plant Biol.15, 89, (2015)
O le Polyploidy e masani ona manatu e tu'uina atu i la'au se fetuunaiga sili atu i fa'afitauli tau le siosiomaga.Tetraploid citrus rootstocks e fa'amoemoe e sili atu le malosi o le fa'apalepale o le fa'amamafa nai lo le diploid.Tele o...
Ougan (Citrus reticulata cv. Suavissima) flavedo extract e taofiofia le gasegase o le kanesa e ala i le faʻalavelaveina o le epithelial-to-mesenchymal transition i sela SKOV3.
Chin.Med.10, 14, (2015)
O le Ougan (Citrus reticulata cv. Suavissima) flavedo extract (OFE) na fa'aalia ai a'afiaga o le tumo ma le le manino o le fa'avae.O lenei suʻesuʻega o loʻo faʻamoemoe e iloilo ai le ono mafai ona faia le anti-metastatic ...
Hesperidin, nobiletin, ma tangeretin o loʻo tuʻufaʻatasia nafa ma le malosi o le anti-neuroinflammatory o le paʻu tangerine (Citri reticulatae pericarpium).
Food Chem.Toxicol.71, 176-82, (2014)
O le taofia o le microglial activation-mediated neuroinflammation ua avea ma taulaiga mautinoa mo le atinaʻeina o meaʻai aoga e togafitia ai faʻamaʻi neurodegenerative.Pa'u mana'i (Citri reticulata...
Faa-Peretania Alia O Neohesperidin
HESPRETIN-7-NEOHESPERIDOSIDE
Hesperetin7-neohesperidoside
4H-1-Benzopyran-4-tasi, 7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2 -(3-hydroxy-4-methoxyphenyl)-, (2S)-
(2S)-5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 2-O-(6-deoxy-α-L- mannopyranosyl)-β-D-glucopyranoside
hesperetin 7-O-neohesperoside
Neohesperdin
Neohesperdin
MFCD00017357
Hesperetin-7-O-neohesperidoside
EINECS 236-216-9
(S)-4'-Methoxy-3',5,7-trihydroxyflavanone-7-[2-O-(α-L-rhamnopyranosyl)-β-D-glucopyranoside]
4H-1-Benzopyran-4-one, 2,3-dihydro-7-((2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl)oxy)-5-hydroxy-2 -(3-hydroxy-4-methoxyphenyl)-, (S)-
Hesperetin 7-O-neohesperidoside
