Obtusin
Fa'aaogāina ole Obtusin
Obtusin, mai fatu o le cassia, o se tagata e sili ona filifilia ma faʻatauvaʻa faʻatauvaʻa o le tagata monoamine oxidase-A (hmao-a), faʻatasi ai ma le IC50 o le 11.12 μ M. Ki o le 6.15.Obtusin e faia se sao puipuia i faʻamaʻi neurodegenerative, aemaise lava le popole ma le atuatuvale.
Igoa o Obtusin
Igilisi Igoa: Obtusin
Bioactivity o Obtusin
Fa'amatalaga: obtusin e mai fatu kesi.O se inhibitor sili ona filifilia ma faʻatauvaʻa o le tagata monoamine oxidase-A (hmao-a), faʻatasi ai ma le IC50 o le 11.12 μ M. Ki o le 6.15.Obtusin e faia se sao puipuia i faʻamaʻi neurodegenerative, aemaise lava le popole ma le atuatuvale.
Vaega Fa'atatau: ala fa'ailoga > > ala fa'ailoga neural > > monoamine oxidase
Ma'i su'esu'e >> ma'i neura
Sini: IC50: 11.12 μ M (hMAO-A)[1] Ki: 6.15 (hMAO-A)[1]
Fa'amatalaga: [1] Paudel P, et al.In Vitro ma le Silico Human Monoamine Oxidase Inhibitory Potential of Anthraquinones, Naphthopyrones, and Naphthalenic Lactones mai Cassia obtusifolia Linn Seeds.ACS Omega.2019 Setema 18;4(14):16139-16152.
Amioga fa'aletino ole Obtusin
Malosi: 1.4 ± 0.1 g / cm3
Fa'apuna: 614.9 ± 55.0 ° C ile 760 mmHg
Fuafuaga mole: c18h16o7
Molecular Weight: 344.315
Fa'asao: 227.0 ± 25.0 ° C
Misasa'o: 344.089600
PSA:102.29000
LogP:4.10
O'omiga ausa: 0.0 ± 1.8 mmHg ile 25°C
Fa'asino Upu: 1.634
Obtusin Safety Information
Fa'ailoga Tiute: 2914690090
Tusiga: Cameron, Donald W;Feutrill, Geoffrey I.;Gamble, Glenn B.;Stavrakis, John Tetrahedron Letters, 1986, vol.27, # 41 itu.4999 - 5002
Obtusin Tiute
Fa'ailoga Tiute: 2914690090
Va'aiga fa'aSaina: Va'aiga fa'aSaina
Aotelega:2914690090 isi quinones. Tulaga va'ava'ai: Leai. VAT:17.0%. Lafoga toe fa'aitiitiga:9.0%. MFN tau:5.5% . Fa'asalalauga lautele:30.0%
Fa'aigoa Fa'aPeretania o le Tiute
9,10-Anthracenedione, 1,7-dihydroxy-2,3,8-trimethoxy-6-methyl-
1,7-dihydroxy-2,3,8-trimethoxy-6-methylanthracene-9,10-dione
1,7-Dihydroxy-2,3,8-trimethoxy-6-methyl-9,10-anthraquinone
Fa'atonuga Tulaga Lelei
1. Na faatauina e le kamupani le faaniukilia maneta resonance (Bruker 400MHz) spectrometer, vai vaega tele spectrometer (LCMS), kesi vaega tele spectrometer (GCMs), tele spectrometer (vai SQD), tele otometi analytical faatinoga maualuga chromatographs suavai, chromatographs vai sauniuni, ma isi. .
2. O lo'o fa'atumauina e le kamupani le galulue fa'atasi ma feso'ota'iga ma fa'alapotopotoga su'esu'e fa'asaienisi e pei o le Shanghai Institute mo le fa'atonutonuina o vaila'au, Nanjing biomedical public service platform ma su'esu'ega ma su'esu'ega nofoaga ole Shanghai Pharmaceutical Industry Research Institute.
3. O lo'o fa'atino e le kamupani su'esu'ega tusipasi lona tolu a le falesu'esu'e, ma e fa'amoemoe e maua le Tusi Fa'amaoniaga Fa'amaoniaga a le Fale Su'esu'e ile CNA ile 2021.
