Ophiopogonin D Cas Nu.945619-74-9
Ophiopogon Saponin D Igoa
Igoa Igilisi:(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)] -6-deoxy-β-D-galactopyranoside
Bioactivity o Ophiopogon Japonicus Saponin D
Fa'amatalaga:Ophiopogon D o se C29 steroidal glycoside e seasea fa'alenatura e tu'u'ese mai le fala ole Ophiopogon japonicus.Ophiopogonin D o se CYP2J3 inducer lea e faateleina ai le CYP2J2 / eets ma le PPAR i totonu o le umbilical vein endothelial cell (HUVECs) α O le faʻaaliga o Ang II na matua faʻalavelaveina Ang II faʻaosoina NF- κ B faʻaliliuina faaniukilia, I κ B α lalo tulafono faatonutonu, intracellular Ca2 + le mamafa ma le faʻagaoioia o cytokines proinflammatory.Ophiopogonin D ua faʻaaogaina e togafitia ai le mumū ma faʻamaʻi cardiovascular mo le faitau afe o tausaga.
Vaega Faatatau
Ala fa'ailoga > > felauaiga transmembrane > > alaala calcium
Su'esu'ega > > ma'i fatu fatu
Ala fa'ailoga > > taamilosaga sela / fa'aleagaina DNA > > PPAR
Vaega su'esu'e > > fula / puipuiga
Sini
PPARα
NF-κB
Ca2+
Pepa Fa'asinomaga:[1].Wang L , et al.Homo-aro-cholestane, furostane ma spirostane saponins mai fatu o Ophiopogonjaponicus.Phytochemistry.2017 Ape;136:125-132.
[2].Huang X, et al.Ophiopogonin D ma EETs faʻaleleia le Ang II-faʻaosoina tali inflammatory e ala i le faʻagaoioia PPARα i HUVECs.Biochem Biophys Res Commun.2017 Aug 19;490(2):123-133.
Fa'aPeretania Alias o Ophiopogon saponin D
(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)] -6-deoxy-β-D-galactopyranoside β-D-Galactopyranoside, (1β,3β,25R) -3-hydroxyspirost-5-en-1-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O-[β-D-xylopyranosyl-(1->3)]-6-deoxy-
(2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-5-hydroxy-2-(((4R,5'R,6R,6aR,6bS,8aS) ,8bR,9S,10R,11aS,12aS,12bS)-4-hydroxy-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a, 6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2 '-pyran]-6-yl)oxy)-6-methyl-4-(((2S,3R,4S,5R) -3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydro- 2H-pyran-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol
Ophiopogonin D
Deacetylophiopogonin C
