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Tsanangudzo:monoammonium glycyrrhizinate hydrate ine zviitwa zvemishonga senge anti-inflammatory, anti allergic, anti gastric ulcer uye anti hepatitis.

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MuVivo Chidzidzo:kuwedzera kwehuremu hwemapapu w / D huremu hwakaderedzwa zvakanyanya nekutonga kweakakwira uye epakati madhizi mag (10 uye 30 mg / kg).Pretreatment with mag (10 uye 30 mg / kg) yakanyatso kuderedzwa TNF- α Uye IL-1 β Chizvarwa che.Mag (10,30 mg / kg) yakaderedza zvakanyanya NF kana ichienzaniswa neLPS- κ Bp65 protein expression.Kusiyana neizvi, LPS yakaderedzwa zvakanyanya ini ndichienzanisa neboka rekutonga κ B- α Protein kutaura, nepo mag (10 uye 30 mg / kg) yakawedzera zvakanyanya I κ B- α Kuratidza [1].Kuenzaniswa neRIF uye INH mapoka, yakaderera-dose uye yakakwirira-dose MAG kurapwa zvakanyanya kuderedzwa ast, alt, TBIL uye TBA mazinga pa14 uye 21 mazuva, zvichiratidza kudzivirira kweMAG paRIF - uye INH -.Kukurudzira kukuvara kwechiropa.MAG boka rekurapa rakawedzera chiropa GSH level pa7, 14 uye 21 mazuva, uye yakaderera zvakanyanya MDA level pa14 uye 21 mazuva muRIF uye INH yakabata makonzo, zvichiratidza kudzivirira kweMAG muRIF - uye.INH yakakonzera kukuvara kwechiropa [2].

Miedzo yemhuka:mbeva [1] muchidzidzo ichi, BALB / c mice (murume, 6-8 mavhiki ekuberekwa, 20-25g) akashandiswa.Mice dzakakamurwa zvisina tsarukano mumapoka e5: boka rekutonga, boka reLPS uye LPS + monoammonium glycyrrhizinate (Mag: 3,10 uye 30mg / kg).Boka rega rega raive ne8 mbeva.Mbeva dzakaiswa anesthetized ne intraperitoneal jekiseni re pentobarbital sodium (50 mg / kg).Mbeva dzakabaiwa intraperitoneally ne mag (3, 10 uye 30 mg / kg) isati yakonzera kukuvara kwakanyanya kwemapapu.Mushure meawa 1, LPS (5 mg / kg) yakabaiwa intracheal kuti iite kukuvara kwakanyanya kwemapapu.Mbeva dzakajairika dzakapihwa PBS [1].Makonzo [2] akashandisa makonzo echirume eWistar (180-220g).Makonzo akakamurwa zvisina tsarukano mumapoka mana: boka rekutonga, RIF uye INH boka, MAG yakaderera-dose boka uye MAG yakakwirira-dose boka, ine 15 makonzo muboka rega rega.Makonzo ari muRIF neINH mapoka akapihwa RIF (60mg / kg) uye INH (60mg / kg) ne gavage kamwe pazuva;Makonzo ari muboka reMAG akataridzirwa ne MAG pachiyero che45 kana 90 mg / kg, uye RIF (60 mg / kg) uye INH (60 mg / kg) yakapiwa maawa 3 mushure me MAG administration;Makonzo aive muboka rekutonga akabatwa nesaline yakajairika.Kuti uongorore simba rekushandisa remishonga, makonzo muboka rimwe nerimwe akaurayiwa 7, 14 uye 21 mazuva mushure mekutonga [2].

Reference:1].Huang X, nevamwe.Anti-Inflammatory Effects yeMonoammonium Glycyrrhizinate paLipopolysaccharide-Induced Acute Lung Injury muMice kuburikidza neRegulating Nuclear Factor-Kappa B Signaling Pathway.Evid Based Complement Alternat Med.2015;2015:272474.
[2].Zhou L, nevamwe.Monoammonium glycyrrhizinate inodzivirira rifampicin- uye isoniazid-induced hepatotoxicity kuburikidza nekugadzirisa matauriro emutakuri Mrp2, Ntcp, uye Oatp1a4 muchiropa.Nhoroondo ye Pharm Biol.2016;54(6):931-7.