Astragaloside IV CAS No. 84687-43-4
Sumo Pfupi
Zita reChirungu:Astragaloside IV;beta-D-Glucopyranoside, (3beta,6alpha,16beta,24R)-20,24-epoxy-16,25-dihydroxy-3-(beta-D-xylopyranosyloxy) -9,19-cyclolanostan-6-yl;(3beta,6alpha,9beta,16beta,20R,24S)-16,25-dihydroxy-3-(beta-D-xylopyranosyloxy)-20,24-epoxy-9,19-cyclolanostan-6-yl beta-D-threo - hexopyranoside
Molecular Formula:C41H68O14
Chemical Name:17- [5-(1-Hydroxyl-1-methyl-ethyl)- 2methyl-tetrahydro- furan-2-yl]-4,4,13,14-tetramethyl-tetradecahydro-cyclopropa[9,10]cyclopenta[a] phenanthren-16-ol-3-β-D-aracopyranosyl-6-β-D-glucoside
Mp:200 ~ 204 ℃
[α]D:-56.6 (c,0.13 muDMF)
UV:λmax203 nm
kuchena:98%
Kwakabva:legume Astragalus membranaceus, Astragalus pubescens.
Kemikari chimiro formula ye astragaloside IV
Physicochemical Properties
[chitarisiko]:white crystalline powder
[kuchena]:pamusoro pe98%, nzira yekuona: HPLC
[chirimwa chinobva]:midzi yeAstragalus Alexandrinus Boiss, Astragalus dissectus, Astragalus membranaceus (Fisch.) Bungede mudzi, Astragalus sieversianus Pall Root yeAstragalus spinosus Vahl, aerial part of Astragalus spinosus Vahl.
[chigadzirwa zvivakwa]:Astragalus membranaceus yakatorwa ibrown yellow powder.
[kutsunga zvirimo]:sarudza neHPLC (Appendix VI D, Vhoriyamu I, Chinese Pharmacopoeia, 2010 Edition).
Chromatographic mamiriro uye system applicability test} octadecyl silane bonded silica gel inoshandiswa sekuzadza, acetonitrile mvura (32:68) inoshandiswa se mobile phase, uye evaporative light scattering detector inoshandiswa pakuona.Huwandu hwe theoretical plates haifanire kunge iri pasi pe4000 zvichienderana neastragaloside IV peak.
Kugadzirira kwereferensi mhinduro, tora huwandu hwakakodzera hweastragaloside IV referensi, kunyatsoiyera, uye wedzera methanol kugadzirira mhinduro ine 0.5mg pa1ml.
Kugadzirira kwebvunzo mhinduro:tora inenge 4G yehupfu kubva muchigadzirwa ichi, uiyera nenzira kwayo, uise muSoxhlet extractor, wedzera 40ml yemethanol, inyudze usiku hwose, wedzera huwandu hwakakodzera hwemethanol, kupisa uye reflux kwemaawa mana, dzora iyo yakanyungudutswa kubva muchidimbu uye fungisisa. iyo kuti iome, wedzera 10ml yemvura kunyungudutsa zvakasara, zunza uye kuibvisa ine saturated n-butanol ka4, 40ml nguva imwe neimwe, sanganisa n-butanol solution, uye ugeze zvakakwana neammonia test solution kaviri, 40ml imwe neimwe. nguva, rasa mhinduro yeammonia, bvisa iyo n-butanol mhinduro, wedzera 5ml mvura kunyungudutsa zvakasara, uye kuitonhodza, Kuburikidza neD101 macroporous adsorption resin column (yemukati dhayamita: 37.5px, column urefu: 300px), elute ine 50ml yemvura. , rasa mushonga wemvura, elute ne 30ml ye40% ethanol, bvisa iyo , elute ne 80ml ye 70% ethanol, unganidza iyo inobuda, inyungudise kuti iome, nyungudutsa zvakasara nemethanol, endesa kune 5ml volumetric flask, wedzera. methanol kuchiyero, zunza zvakanaka, uyewobva wazviwana.
Determination method:kunyatsotora 10% yereferensi mhinduro zvakateerana μ l, 20 μ l.Test mhinduro 20 imwe neimwe μ l.Jekiseni muchromatograph yemvura, itarise, woiverengera nelogarithm equation yenzira yekunze yemapoinzi maviri.
Yakaverengerwa seyakaoma chigadzirwa, zvirimo zveastragaloside IV (c41h68o14) hazvizove pasi pe0.040%
Pharmacological Action
Izvo zvakakosha zvinoshanda zveAstragalus polysaccharides uye astragaloside.Astragaloside yakakamurwa kuita astragaloside I, astragaloside II uye astragaloside IV.Pakati pavo, astragaloside IV, astragaloside IV, ine yakanakisa biological chiitiko.Astragaloside IV haina kungoita mhedzisiro yeAstragalus polysaccharides, asiwo mamwe asingaenzaniswi mhedzisiro yeAstragalus polysaccharides.Kusimba kwayo kwakanyanya kudarika zvakapetwa kaviri kune yakajairwa astragalus polysaccharides, uye iyo antiviral mhedzisiro inosvika makumi matatu iyo yeAstragalus polysaccharides.Nekuda kweiyo yakaderera yemukati uye yakanaka maitiro, inozivikanwa zvakare se "super astragalus polysaccharide".
1.Enhance kudzivirirwa uye kudzivirira zvirwere.
Inogona kunyanya uye isingabatanidzi miviri yekunze inopinda mumuviri, kusimudzira chaiyo, immune uye isina kudzivirirwa, uye kugadzirisa kudzivirira kwechirwere chemuviri.Inogona kusimudzira kugadzirwa kweantibody, uye kuwedzera zvakanyanya huwandu hwemaantibody anoumba maseru uye hemolysis bvunzo kukosha.Astragaloside IV inogona kuvandudza zvakanyanya lymphocyte shanduko nhanho uye E-rosette yekugadzira mwero wecoccidia inobaiwa huku.Iyo inobudirira activator ye monocyte macrophage system.Astragaloside IV inogonawo kuvandudza oxidation, GSH-Px uye SOD zviitiko munhengo dzemuviri, uye kuvandudza kudzivirira kwemuviri uye kuchengetedzwa kwekudzivirira kwezvirwere.
2.Antiviral effect.
Iro antiviral musimboti: inokurudzira kushanda kwema macrophages uye T masero, kuwedzera nhamba yeE-ring inoumba masero, induce cytokines, inosimudzira induction ye interleukin, uye inoita kuti muviri wemhuka ubudise endogenous interferon, kuitira kuti uwane chinangwa cheantiviral.Mhedzisiro yacho yakaratidza kuti chiyero chekudzivirira che astragaloside IV paIBD yaive 98.33%, iyo yaigona kudzivirira nekurapa IBD, uye pakanga pasina mutsauko wakakosha uchienzaniswa neyakakura immune egg yolk solution.Astragaloside inogona kukwidziridza mashandiro eantioxidant enzymes mumuviri, kuderedza zvirimo muLP0, kuderedza kukuvadzwa kweiyo reactive okisijeni marudzi, uye nekudaro kuderedza huwandu hwechiitiko uye kufa kweMD.Inogona kuvandudza kuderera kwekudzivirira kwemuviri kunokonzerwa nebundu, kukurudzira kushandiswa kwemasero ekudzivirira muviri, kusunungura endogenous zvinhu, uye kudzivirira kuuraya uye kuvharidzirwa kwemasero emamota anokonzerwa ne peroxidation;Astragaloside inogona kutadzisa kukura kwehutachiona hwefuruwenza uye basa re sialidase.Iyo ine mhedzisiro yakakosha pakushanda kwefuruwenza virus cell membrane uye adsorption uye kupinza kwehutachiona kumasero anonzwisa tsitsi.Kufa nekukandira mazai ehuku zvakaderedzwa zvakanyanya, uye chiyero chekukandira mazai uye kupora kwehutano hwemazai zvaive zvakanyanya nani pane zveamantadine chete boka rekutonga, uye mhedzisiro yeAstragalus polysaccharide yakanga isiri pachena;Astragaloside IV ine kuuraya kwakasimba uye inhibitory mhedzisiro pahutachiona.Chirevo ndechekuti kushandiswa kweastragaloside IV kusati kwawanikwa kwehutachiona neNd virus, saka zviri nani kushandisa astragaloside IV kwenguva yakareba, Avian myeloblastic leukemia (AMB) 3 mazuva ekare AA broilers akadyiswa astragaloside IV nehutachiona. yehutachiona hweAMB, inogona kuderedza huwandu hwechiitiko uye kufa kweAMB, kuwedzera huwandu hweLPO mumitezo yekudzivirira senge spleen uye thymus, inosimudzira zvakanyanya kutsvaira kwespleen uye thymus nedzimwe nhengo dzemuviri dzekudzivirira pane myeloid inotorwa bundu masero.Kechipiri, astragaloside IV ine pachena kudzivirira uye kurapa mhedzisiro pazvirwere zvekufema senge utachiona laryngotracheitis.Shandisa.
3. Anti stress effect.
Astragaloside IV inogona kudzivirira adrenal hyperplasia uye thymus atrophy munguva yambiro yekupindura kwekushushikana, uye kudzivirira shanduko dzisina kujairika munguva yekupikisa uye kutadza nguva yekupindura kwekushushikana, kuitira kuti uite basa rekurwisa kusagadzikana, kunyanya ine yakakosha nzira mbiri. Mhedzisiro pama enzymes mukuita kwekudya metabolism, uye inoderedza uye inobvisa kukanganiswa kwekupisa kwekushushikana pane physiological basa remuviri kune imwe nhanho.
4. Semutsigiri wekukura.
Inogona kusimudzira physiological metabolism yemasero, kukurudzira kutenderera kweropa, kuwedzera metabolism yemuviri wemhuka, uye kutamba basa rekudya uye hutano hwehutano.Tsvagiridzo inoratidza kuti inogona kukurudzira kukura kwebifidobacteria uye lactic acid mabhakitiriya uye ine mhedzisiro yeprobiotics.
5. Astragaloside IV inogona kuvandudza cardiopulmonary function.
Simbisa chibvumirano chemoyo, chengetedza myocardium uye ramba kutadza kwemoyo.Iinewo migumisiro yekudzivirira chiropa, anti-inflammatory uye analgesic.Inogona kushandiswa se adjuvant therapy kune dzakasiyana siyana dzehutachiona uye bhakitiriya zvirwere.
