Chlorogenic Acid CAS No.327-97-9
Ruzivo Rwakakosha
Chlorogenic acid ine huwandu hwakawanda hwehutachiona hwehutachiona, asi inogona kuvharwa nemapuroteni mu vivo.Zvakafanana necaffeic acid, oral kana intraperitoneal jekiseni inogona kuvandudza pakati excitability yemakonzo.Inogona kuwedzera intestinal peristalsis yemakonzo nemakonzo uye kushushikana kwechibereko chegonzo.Iyo ine cholagogic effect uye inogona kuwedzera bile secretion mumakonzo.Hune sensitization effect pavanhu.Asthma uye dermatitis zvinogona kuitika mushure mekufema guruva rechirimwa rine chigadzirwa ichi.
Zita rechiChinese: Chlorogenic acid
Zita rekunze: Chlorogenic acid
Mushonga weKemikari: C16H18O9
Molecular uremu: 354.31
Nhamba yeCAS:327-97-9
Melting Point: 208 ℃;
Boiling Poindi: 665 ℃;
Density: 1.65 g / masendimita ³
Flash Point: 245.5 ℃
Refractive Index: - 37 °
Toxicology Data
Acute toxicity: shoma inouraya dose (gonzo, abdominal mhango) 4000mg / kg
Ecological Data
Zvimwe zvinokuvadza: chinhu chinogona kukuvadza zvakatipoteredza, uye kunyanya kukoshesa kunofanira kubhadharwa kumuviri wemvura.
Source
Eucommia ulmoides Oliv Lonicera dasytyla Rehd Maruva akaomeswa kana ane maruva anotumbuka, muchero weBritish Hawthorn muRosaceae, cauliflower mu dioscoreaceae, Salix mandshurica muApocynaceae, Polypodiaceae chirimwa Eurasian mvura keel rhizomenia midzi yemiti, Versian water keel rhizomenia uye midzi , Polygonaceae chirimwa chakafuratira uswa huswa, Rubiaceae chirimwa tarpaulin huswa hwese, honeysuckle chirimwa capsule Zhai Whole grass.Mashizha embambaira mumhuri Convolvulaceae.Mbeu dzekofi diki yemuchero, yepakati muchero kofi uye hombe yemuchero kofi.Mashizha nemidzi yeArctium lappa
Kushandiswa kweChlorogenic Acid
Chlorogenic acid ine huwandu hwakawanda hwezvinhu zvipenyu.Tsvagiridzo yezviitwa zvebhaibheri zvechlorogenic acid mune sainzi yemazuva ano yakapinda mukati mezvikamu zvakawanda, senge chikafu, hutano hwehutano, mushonga, indasitiri yemakemikari yemazuva ese uye zvichingodaro.Chlorogenic acid inokosha bioactive chinhu, iyo ine mabasa eantibacterial, antiviral, kuwedzera leukocyte, kudzivirira chiropa uye gallbladder, anti-tumor, kuderedza ropa reropa, kuderedza lipid yeropa, kuchenesa mahara radicals uye kunakidza yepakati tsinga system.
Antibacterial uye antiviral
Eucommia ulmoides chlorogenic acid ine yakasimba antibacterial uye anti-inflammatory effects, aucubin nemapolymers ayo ane antibacterial madhara ari pachena, uye aucubin ine inhibitory madhara paGram-negative uye mabhakitiriya akanaka.Aucubin ine bacteriostatic uye diuretic madhara, uye inogona kukurudzira kuporesa maronda;Aucubin uye glucoside inogonawo kuburitsa pachena antiviral mhedzisiro mushure mekutanga tsika, asi haina antiviral basa.The Institute of aging Medical Sayenzi, Aichi Medical University, yakasimbisa kuti alkaline chinhu chakatorwa muEucommia ulmoides Oliv.Ane kugona kuparadza hutachiona hwehutachiona hwevanhu.Mushonga uyu unogona kushandiswa kudzivirira nekurapa AIDS.
Antioxidation
Chlorogenic acid inoshanda phenolic antioxidant.Antioxidant simba rayo rakasimba kudarika caffeic acid, p-hydroxybenzoic acid, ferulic acid, syringic acid, butyl hydroxyanisole (BHA) uye tocopherol.Chlorogenic acid ine antioxidant effect nokuti ine imwe huwandu hweR-OH radical, iyo inogona kuumba hydrogen radical ine antioxidant effect, kuitira kuti ibvise basa re hydroxyl radical, superoxide anion uye mamwe mahara radicals, kuitira kudzivirira matishu kubva kune oxidative. kukuvara.
Yemahara radical scavenging, anti-kuchembera, anti musculoskeletal kuchembera
Chlorogenic asidhi uye zvinobva mairi zvine simba remahara radical scavenging mhedzisiro pane ascorbic acid, caffeic acid uye tocopherol (vitamin E), inogona kunyatso sveta DPPH yemahara radical, hydroxyl free radical uye superoxide anion free radical, uye inogonawo kutadzisa oxidation ye low-density. lipoprotein.Chlorogenic acid inoita basa rakakosha mukutsvagisa mahara radicals, kuchengetedza yakajairika chimiro uye kushanda kwemasero emuviri, kudzivirira uye kunonoka kuitika kwebundu mutation uye kuchembera.Eucommia chlorogenic acid ine chinhu chakakosha chinogona kukurudzira kuumbwa uye kuora kwe collagen muganda remunhu, pfupa uye tsandanyama.Iine basa rekusimudzira metabolism uye kudzivirira kuderera.Inogona kushandiswa kudzivirira kudzikira kwebhonzo uye tsandanyama kunokonzerwa nekuremera kwenzvimbo.Panguva imwecheteyo, zvinowanikwa kuti Eucommia chlorogenic acid ine pachena anti free radical effect zvese mu vivo uye in vitro.
Inhibition yekuchinja uye antitumor
Kuedza kwemazuva ano kwemishonga kwakaratidza kuti Eucommia ulmoides chlorogenic acid ine migumisiro ye-anti-cancer uye anti-cancer.Nyanzvi dzeJapan dzakadzidza nezve antimutagenicity yeEucommia ulmoides chlorogenic acid uye yakaona kuti mhedzisiro iyi ine hukama ne anti mutagenic zvikamu zvakaita se chlorogenic acid, zvichiburitsa kukosha kwakakosha kwechlorogenic acid mukudzivirira bundu.
Polyphenols mumiriwo nemichero, zvakadai seklorojeni asidhi uye caffeic acid, inogona kudzivisa mutagenicity yecarcinogens aflatoxin B1 uye benzo [a] - pyrene nekudzivisa ma enzymes akaiswa;Chlorogenic acid inogonawo kuwana anti-cancer uye anti-cancer mhedzisiro nekudzikisa kushandiswa kwecarcinogens uye kutakura kwavo muchiropa.Chlorogenic acid ine zvakakosha inhibitory mhedzisiro pane colorectal cancer, kenza yechiropa uye laryngeal cancer.Inofungidzirwa kuti inoshanda kemikari inodzivirira kurwisa kenza.
Dziviriro mhedzisiro pacardiovascular system
Seyemahara radical scavenger uye antioxidant, chlorogenic acid yakaratidzwa nehuwandu hukuru hwekuyedza.Iyi biological chiitiko che chlorogenic acid inogona kuchengetedza yemoyo system.Isochlorogenic acid B ine simba rakasimba pakusimudzira kusunungurwa kweprostacyclin (PGI2) uye anti platelet aggregation mumakonzo;Iyo inhibition rate yeSRS-A kuburitswa kwakakonzerwa neantibody kune guinea pig mapapu mamarara aive 62.3%.Isochlorogenic acid C yakakurudzirawo kusunungurwa kwePGI2.Mukuwedzera, isochlorogenic acid B ine inhibitory effect pa platelet thromboxane biosynthesis uye endothelin kukuvara kunokonzerwa nehydrogen peroxide.
Hypotensive effect
Zvakaratidzwa nemakore mazhinji emakiriniki ekuyedzwa kuti Eucommia chlorogenic acid ine pachena antihypertensive mhedzisiro, yakagadzikana yekurapa maitiro, isiri-chepfu uye isina mhedzisiro.Yunivhesiti yeWisconsin yakaona kuti zvinobudirira zvikamu zveEucommia ulmoides zvakasvibirira kuderedza BP iterpineol diglucoside, aucubin, chlorogenic acid, uye Eucommia ulmoides chlorogenic acid polysaccharides.[5]
Mamwe mabasa ebhayoloji
Nekuti chlorogenic acid ine yakakosha inhibitory mhedzisiro pa hyaluronic acid (HAase) uye glucose-6-phosphatase (gl-6-pase), chlorogenic acid ine imwe mhedzisiro pakupora kweronda, hutano hweganda nekunyorova, majoini ekuzora, kudzivirira kuzvimba uye kuzvimba. kuenzanisa kudzora kweglucose yeropa mumuviri.Chlorogenic acid ine inhibitory yakasimba uye inouraya mhedzisiro pazvirwere zvakasiyana uye mavhairasi.Chlorogenic acid ine pharmacological mhedzisiro yekudzikisa BP, antibacterial, antiviral, anti-inflammatory, kuwedzera masero machena eropa, kudzivirira chirwere cheshuga, kuwedzera gastrointestinal motility uye kukurudzira gastric secretion.Zvidzidzo zvakaratidza kuti oral chlorogenic acid inogona kukurudzira zvakanyanya secretion ye bile uye ine mhedzisiro yekubatsira gallbladder nekudzivirira chiropa;Inogonawo kudzivirira zvinobudirira hemolysis yerat erythrocytes inokonzerwa neH2O2.
