Cycloastragenol CAS No. 78574-94-4
Chigadzirwa Specification
[zita]:cycloastragalus doro
[zvinoreva]:triterpenoid cyclic flavonol
[Zita reChirungu]:cycloastragenol
[molecular formula]:C30H50O5
[molecular huremu]:490.71
[CAS Nha.]:78574-94-4
[nzira yekuona]:HPLC ≥ 98%
[Mashoko]:20mg 50mg 100mg 500mg 1g (inogona kuiswa mukati maererano nezvinodiwa nevatengi)
[Zvinhu]:chigadzirwa ichi chine colorless acicular crystal
[kushanda uye kushandiswa]:Chigadzirwa ichi chinoshandiswa pakusarudza zvirimo, kuzivikanwa, kuyedza kwemishonga, kuongorora chiitiko uye kumwe ongororo yesainzi.Zvakadai sekutonga kwesero, intragastric test, kuongororwa kwehutano hwemukati wefekitari yemishonga, etc.Source: Astragalus membranaceus (Fisch.) Bge.Dried root extract
Kuchengeta Nzira
2-8 ° C, yakavharwa kubva kuchiedza uye yakachengetwa pakadzika.
Cherechedza
Ichi chigadzirwa chinofanira kuchengetwa pakupisa kwakadzika.Kana ikaratidzwa kumhepo kwenguva yakareba, zvinyorwa zvichaderedzwa.
Chromatographic conditions} chromatographic column: Zorbax rx-c18 (4.6mm) × 150mm)，5 μ m; Nharembozha chikamu: acetonitrile mvura (30:70);Flow rate: 1.0ml/min, column tembiricha: 35 ℃, ELSD parameters: drift tube tembiricha: 105 ℃, nitrogen flow rate: 2.70ml/min.
Physicochemical zvivakwa: density 1.20
Bioactivity ye cycloastragenol
Cycloastragalol inonzi triterpene saponin compound, iyo inonzi Astragalus membranaceus (Fisch.) Iyo hydrolyzate yechinhu chinoshanda muBunge).Astramembrangenin ine kuchengetedzwa kwemuromo uye ine huwandu hwakasiyana hwemishonga yemishonga, kusanganisira telomerase activation, telomere prolongation, anti-inflammatory uye antioxidant properties.Astramembrangenin ine anti-aging properties.CAG inomutsa chiitiko che telomerase muvanhu vachangozvarwa keratinocytes uye makonzo nerve masero uye induces CREB activation.Astramembrangenin inogona kunge iine hutsva hwekurapa mukuora mwoyo
Zvikamu zvinoenderana:
Chiratidzo nzira>> apoptosis>> apoptosis
Tsvagiridzo yemunda > > kuzvimba / kusadzivirirwa
Tsvagiridzo yemunda > > zvirwere zvetsinga
In Vitro Chidzidzo:
Kuenzaniswa nekutonga kwekutakura muHEK tsika, nyeredzi membrane protein (0-10 μ M; 3-6 mazuva) yakawedzera sero kukura [1].Astramembrangenin (0.3 μ M;5-90 maminetsi) yakakonzera CREB phosphorylation muprimary cortical neurons, uye kutaura kweCREB yakazara mumhando dzose dzemasero hakuna kukanganiswa neCAG [1].Nyeredzi membrane protein (3) μ M;6-48 maawa) inogona kukurudzira mu vivo chiratidzo chekushandura mueuroni, kuwedzera TERT mRNA kutaura, uye kuratidza kuwedzera bcl 2 mRNA kutaura [1].Cell viability assay [1] cell line: HEK cell concentration: 1 μ M, 3 μ M, 10 μ M tsika nguva: 3-6 mazuva emigumisiro: kukura kwesero kwakapetwa kaviri pamazuva matanhatu.Western blot analysis [1] cell line: neuron cell concentration: 0.3 μ M tsika nguva: 5 maminitsi, 15 maminitsi, 30 maminitsi, 90 maminitsi.Migumisiro: CAG yakakonzera CREB activation mueuroni.RT-PCR [1] cell line: neuron cell concentration: 3 μ M tsika nguva: 6-48 maawa emigumisiro: kutaura kweTERT uye Bcl 2 mRNA yakawedzera.
Reference:
[1].Ip FC, nevamwe.Cycloastragenol ine simba telomerase activator mumaseru neuronal: zvinokonzeresa pakuora mwoyo manejimendi.Neurosignals.2014;22(1):52-63.
[2].Yu Y, nevamwe.Cycloastragenol: Inonakidza novel mumiriri wezvirwere zvinoenderana nezera.Exp Ther Med.2018 Sep;16(3):2175-2182.
[3].Sun C, nevamwe.Cycloastragenol mediates activation uye kuwedzera kudzvinyirira mu concanavalin A-induced mouse lymphocyte pan-activation model.Immunopharmacol Immunotoxicol.2017 Jun;39(3):131-139.
Physicochemical Properties yeCycloastragenol
Density:1.2 ± 0.1 g / cm3
Boiling point:617.2 ± 55.0 ° C pa760 mmHg
Melting point:241.0 kusvika 245.0 ° C
Molecular formula:c30h50o5
Molecular uremu:490.715
Flash point:327.1 ± 31.5 ° C
Hukuru chaihwo:490.365814
PSA:90.15000
LogP:3.82
Steam pressure:0.0 ± 4.0 mmHg pa25 ° C
Refractive index:1.582
Cycloastragenol Chengetedzo Ruzivo
Kodhi yekufambisa yezvinhu zvine njodzi: nonh yemhando dzese dzekutakura
RTECS nhamba;GX8265000
Customs Code: 2942000000
Cycloastragalol Tsika
Customs Code: 2942000000
Cycloastragalol Literature
Cycloastragenol ine simba telomerase activator mumaseru neuronal: zvinokonzeresa pakuora mwoyo manejimendi.
Neurosignals 22(1) , 52-63, (2014)
Cycloastragenol (CAG) is aglycone ye astragaloside IV.Yakatanga kucherechedzwa pakuongorora Astragalus membranaceus zvinyorwa zvezvishandiso zvinoshanda zvine anti kuchembera zvivakwa.Chidzidzo chezvino che ...
Novel telomerase activator inodzvinyirira kukuvara kwemapapu mumurine modhi yeidiopathic pulmonary fibrosis.
PLoS ONE 8(3) , e58423, (2013)
Kubuda kwezvirwere zvine chekuita nekusashanda zvakanaka kwetelomere, kusanganisira AIDS, aplastic anemia uye pulmonary fibrosis, kwakasimbisa kufarira mune telomerase activators.Isu tinoshuma kuzivikanwa kwe n...
Telomerase-based pharmacologic kukwidziridzwa kweantiviral basa remunhu CD8+ T lymphocytes.
J. Immunol.181(10) , 7400-6, (2008)
Telomerase reverse inonyora telomere DNA kumigumo yemakromosomes ane mutsara uye inodzoreredza kuchembera kwemasero.Mukupesana neakawanda akajairwa somatic masero, ayo anoratidza kushoma kana kusaita telomerase chiitiko, immun ...
Chirungu Alias of Cycloastragalol
9,19-Cyclolanostane-3,6,16,25-tetrol,20,24-epoxy-,(3β,6α,9β,16β,20R,24S)-
Astramembrangenin
(3β,6α,9β,16β,20R,24R)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol
19-Cyclolanostane-3,6,16,25-tetrol,20,24-epoxy-,(3β,6α,9β,16β,20R,24R)-
(3β,6α,9β,16β,20R,24S)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol
Cyclosieversigenin
Cyclogalegegenin
