Danshensu
Chigadzirwa Specification
Zita rakajairika:Danshensu
Nhamba yeCAS:76822-21-4
Density:1.5 ± 0.1 g / cm3
Molecular Formula:C9H10O5
MSDS:n / nzvimbo inopenya: 259.1 ± 23.8 ° C
Chirungu Zita:Danshensu
Molecular Weight:198.17
Boiling Point:198.17
Melting Point:N/ A
Zita reDanshensu
Chinese Name:Danshensu
Chirungu Zita:(2R) - 3 - (3,4-dihydroxyphenyl) - 2-hydroxypropanoic acid
Chine zita reChinese:B - (3,4-dihydroxyphenyl) lactic acid |cryptotanshinone |B - (3.4-dihydroxyphenyl) lactic acid
Danshensu bioactivity
Tsanangudzo:Danshensu inhengo inobudirira yeSalvia miltiorrhiza, iyo inogona kumisa Nrf2 nzira yekuratidzira uye kudzivirira moyo wemoyo.
Related Categories: chiratidzo nzira>> autophagy>> autophagy
Chiratidzo nzira>> NF- κ B chiratidzo nzira>> keap1-nrf2
Tsvagiridzo > > chirwere chemoyo
Natural Products > > benzoic acids
In Vitro Chidzidzo:Danshensu (DSS) yakaderedza zvakanyanya mazinga e-marker enzymes (creatine kinase uye lactate dehydrogenase) yecoronary outflow uye myocardial infarction size.Izvi zvinogona kukurudzira zvakanyanya kudzoreredza kwemoyo basa mushure mekukuvara kweI / R.DSS zvakare ine ROS scavenging chiitiko uye inosimudzira chiitiko cheendogenous antioxidants seSOD, katsi, MDA, GSH-Px uye HO-1 nekuita iyo nyukireya factor erythrocyte-2 inoenderana factor 2 (Nrf2) yekusaina nzira inofambiswa neAkt uye ERK1.2 muWestern blot analysis [2].
MuVivo Chidzidzo:Kurapa kwakanyanya nedoro rimwe chete reDanshensu hakuna kuchinja plasma tHcy mumakonzo ane tHcy yakajairika.Kusiyana neizvi, Danshensu yakaderedza zvakanyanya tHcy mumakonzo ane tHcy yakakwirira.Iyo yakakwira mazinga ecysteine uye glutathione mushure mekurapwa neDanshensu inoratidza kuti mhedzisiro yayo yekudzikisa tHcy iri kuburikidza nekuwedzera basa re trans vulcanization nzira [1].
Miedzo yemhuka:makemikari ose akanyungudutswa mu saline kunze kwe tolcapone yakanyungudutswa mu saline ine 20% (V / V) peg 200. Munguva yekuedza, makonzo akatsanya usiku hwose uye akagoverwa kumapoka akasiyana-siyana.Mushure me ether anesthesia, anenge mazana maviri akabviswa kubva ku orbital sinus μ L ropa, uye nokukurumidza disinfect nedoro uye kusvina nekotoni.Masampuli eropa akaunganidzwa pakarepo mumachubhu epolypropylene ane heparin sodium uye centrifuged pa5000 g pa5 ° C kwemaminitsi matatu.Iwo akagadzirirwa plasma samples akachengetwa pa - 20 ℃ uye akaongororwa mukati memaawa makumi mana nemasere.
References:[1] YG Cao, et al.Inobatsira zvinokonzerwa nedanshensu, chikamu chinoshanda cheSalvia miltiorrhiza, pane homocysteine metabolism kuburikidza ne-trans-sulphuration nzira mumakonzo.Br J Pharmacol.2009 Jun;157(3): 482–490.
[2].Yu J, nevamwe.Danshensu inodzivirira moyo wakasarudzika kurwisa ischemia reperfusion kukuvara kuburikidza ne activation yeAkt/ERK1/2/Nrf2 kusaina.Int J Clin Exp Med.2015 Sep 15;8(9):14793-804.
Physicochemical properties yeDanshensu
Density:1.5 ± 0.1 g / cm3
Molecular Formula:C9H10O5
Flash Point:259.1 ± 23.8 ° C
LogP:- 0.29
Refractive Index:1.659
Boiling Point:481.5 ± 40.0 ° C pa760 mmHg
Molecular Weight:198.17
PSA:97.99000
Steam Pressure:0.0 ± 1.3 mmHg pa25 ° C
Danshensu Safety Information
Customs Code: 2942000000
Chirungu aas of Danshensu
Danshensu
Sodium (2R) -3-(3,4-dihydroxyphenyl) -2-hydroxypropanoate
(2R) -3-(3,4-Dihydroxyphenyl) -2-hydroxypropanoic acid
Benzenepropanoic acid, α, 3,4-trihydroxy-, (αR) -
Benzenepropanoic acid, α,3,4-trihydroxy-, sodium munyu, (αR)- (1:1)
Salvinic
