Fraxin;Paviin;Fraxoside;Fraxetol- 8-glucoside CAS No.524-30-1
Ruzivo Rwakakosha
Nhamba yeCAS:524-30-1 [1]
EINECS Nha.:208-355-5
Molecular Formula:c16h18o10
Molecular Weight:370.3081
Molecular Structure:(Mufananidzo 1)
Properties:Chiedza cheyero acicular crystal kana flake crystal.
Density:1.634g/cm3
Boiling Point:722.2 ° C pa760 mmHg
Flash Point:267 ° C
Steam Pressure:6.87e-22mmhg pa25 ° C
Bioactivity yeFraxin
Tsanangudzo:Fraxin inogona kuparadzaniswa kubva kuAcer tegmentosum, F. ornus uye a.hippocastanum.I glycoside yefraxine [1] uye ine antioxidant, anti-inflammatory uye anti metastasis mabasa.Fraxin inoratidzira antioxidant chiitiko nekudzivisa cyclic adenylate phosphodiesterase [2].
Chinangwa:cyclo AMP phosphodiesterase enzyme [2]
In Vitro Chidzidzo:Fraxin (100 μ M) Haina cytotoxicity kuHep G2 masero.Fraxin pane isiri cytotoxic concentrations yakaderedza zvakanyanya t-BHP yakakonzera ROS kugadzirwa nenzira inotsamira mudosi [1].Fraxin (0.5 mm) inogona kutsvaira ma radicals emahara pakakwirira uye ine cytoprotective mhedzisiro paH2O2 yakapindirana oxidative kusagadzikana [2].
In vivo kudzidza:Fraxin (50 mg / kg, PO) yakavharira zvakanyanya CCl4 yakakonzera kukwirira kweALT uye AST.Fraxin (10 uye 50 mg/kg, PO) yakaderedza zvakanyanya mazinga eGSSG (1.7 ± 0.3 uye 1.5 ± 0.2 nm / g chiropa, zvichiteerana) zvichienzaniswa nemazinga eGSSG muboka rakarapwa reCCl4.
Reference:.Fraxin (50 mg/kg, po) inovhara zvakanyanya kukwidziridzwa kweCCl4-induced yeALT uye AST.Fraxin (10 uye 50 mg/kg, po) inoderedza zvakanyanya mazinga eGSSG (1.7±0.3 uye 1.5±0.2 nM/g chiropa, zvichiteerana) zvichienzaniswa nemazinga eGSSG eboka rakarapwa neCCl4 [1].
[2].Whang WK, nevamwe.Zvisikwa zvinosanganisirwa, fraxin uye makemikari ane hukama ane hukama nefraxin anodzivirira maseru kubva kune oxidative kusagadzikana.Exp Mol Med.2005 Oct 31;37(5):436-46.
