Hyperoside;Hypercin Cas No. 482-36-0
Zvinodhaka Ruzivo
[zita rechigadzirwa] hypericin
[Zita reChirungu] Hyperoside
[alias] hyperin, quercetin 3-galactoside, quercetin-3-o-galactoside
[molecular formula] c21h20o12
[molecular uremu] 464.3763
[C seNhamba.] 482-36-0
[Kemikari kupatsanurwa] flavonoids
[mabviro] Hypericum perforatum L
[Mashoko] > 98%
[Safety terminology] 1. Usafeme huruva.2.Muchiitiko chetsaona kana kusagadzikana, tsvaga kurapwa nekukurumidza (ratidza chinyorwa chayo kana zvichibvira).
[Pharmacological efficacy] Hypericin inoparadzirwa zvakanyanya.Icho chinhu chakakosha chigadzirwa chepanyama chine mabasa akasiyana-siyana ehupenyu, zvakadai se-anti-inflammatory, antispasmodic, diuretic, chikosoro, kuderedza ropa, kuderedza cholesterol, protein assimilation, yemunharaunda uye yepakati analgesia, uye zvinodzivirira pamwoyo nemidziyo yeuropi.
[Zvenyama nemakemikari zvimiro] Chiedza yeyero acicular crystal.Nzvimbo yakanyunguduka ndeye 227 ~ 229 ℃, uye kutenderera kwemaziso ndiko - 83 ° (C = 0.2, pyridine).Inonyungudika nyore nyore mu ethanol, methanol, acetone uye pyridine uye inogadzikana pasi pemamiriro ezvinhu.Inopindirana ne hydrochloric acid magnesium powder kuti ibudise cherry tsvuku, uye ferric chloride inobata girini, α- Naphthol reaction yaiva yakanaka.
[Risk terminology] Zvinokuvadza kana ikamedzwa.
Pharmacological Action
1. Hypericin ine zvakakosha zvemunharaunda analgesic effect, iyo isina simba kupfuura morphine, yakasimba kudarika aspirin, uye haina kutsamira.Hypericin rudzi rutsva rweanalgesic yemunharaunda Panguva imwe chete,
2. Hypericin ine simba rakanaka rekudzivirira pane myocardial ischemia-reperfusion, cerebral ischemia-reperfusion uye cerebral infarction.
3. Hypericin ine pachena anti-inflammatory effect: mushure mekusimwa kwebhola yemvere dzemakwai, makonzo akaiswa intraperitoneally ne 20mg / kg zuva rega rega kwemazuva 7, izvo zvakadzivisa zvakanyanya kuvhiringidza.
4. Iine yakasimba antitussive effect.
5. Kufananidzwa.
6. Inhibition yakasimba yealdose reductase inogona kubatsira kudzivirira chirwere cheshuga cataract.
Dziviriro mhedzisiro pane myocardial ischemia
Hypericin inogona kuderedza apoptosis rate ye cardiomyocytes inokonzerwa ne hypoxia reoxygenation, inhibisa kusunungurwa kwe lactate dehydrogenase, kuvandudza basa remyocardial superoxide dismutase (SOD) mumakonzo ane myocardial ischemia-reperfusion kukuvara, kuderedza kugadzirwa kwemalondialdehyde (MDA), inhibit the kuwedzera kwemyocardial phosphokinase (CPK) mu serum, uye kuderedza kuumbwa kweokisijeni isina radical uye nitric oxide yakasununguka radical, Kuti idzivirire myocardium uye kuderedza kukuvara kwe cardiomyocyte uye cardiomyocyte apoptosis inokonzerwa neschemia-reperfusion.
Dziviriro mhedzisiro pane cerebral ischemia
Hypericin inogona kunyatso kuvharidzira kuderera kweformazan yemukati mucerebral slices mushure me hypoxia glucose deprivation reperfusion kukuvara, kuwedzera huwandu hweasara neuron mucortex uye striatum yecerebral slices munzvimbo yeischemic, uye kuita kuti morphology ye neuron ive yakakwana uye yakagovaniswa zvakanaka.Inhibit kuderera kwekuita neuronal kunokonzerwa ne hypoxia glucose deprivation reperfusion kukuvara.Inhibisa kudzikira kweSOD, LDH uye glutathione peroxidase (GSHPx) zviitiko.Maitiro ayo anogona kunge ane chekuita nemahara radical scavenging, inhibition yeCa2 kupinda uye anti lipid peroxide kuumbwa.
Kudzivirira maitiro pachiropa uye gastric mucosa
Hypericin ine inodzivirira inodzivirira pachiropa tishu uye gastric mucosa.Maitiro ayo ane hukama ne antioxidant mhedzisiro, kusimudzira kudzoka kweN0 level kune yakajairika uye kuwedzera SOD chiitiko.
Antispasmodic analgesic effect
Chidzidzo chacho chakawana kuti analgesic effect ye hypericin inogadzirwa nekuderedza Ca 2 mumarwadzo emagetsi ekupedzisira.Panguva imwecheteyo, hypericin inogona kuvharidzira Ca 2 kupinda kunokonzerwa nepamusoro potassium, zvichiratidza kuti hypericin inovharawo Ca channel muhutano hwetsinga.Zvinokurudzirwa zvakare kuti hypericin inogona kunge iri blocker yeCa 2 chiteshi.Kuongororwa kwekiriniki kunoratidza kuti jekiseni re hypericin rakafanana neatropine mukurapa kwekutanga dysmenorrhea.Kunze kwemamwe mashoma ekukotsira, haina maitiro akajairika akadai se tachycardia, mydriasis uye kunzwa kupisa.Iyo yakanaka antispasmodic uye analgesic.
Hypolipidemic effect
Hypericin inogona kuderedza zvakanyanya serum TC uye kuwedzera HDL / TC chiyero mumakonzo ane mafuta akawanda, zvichiratidza kuti hypericin inogona kuderedza cholesterol, kutonga ropa lipid, uye kugadzirisa basa reHDL uye serum SOD mumakonzo.Izvi zvinogona kuderedza zvakanyanya kukanganisa kwe superoxide mahara radical kune vascular endothelium mu hyperlipidemia, uye inobatsira pakuora uye metabolism ye lipid peroxide kuchengetedza vascular endothelium.
Wedzerai immune function
Hypericin pamadosi e300 mg/kg uye 150 mg/kg in vivo inogona kuvharisa zvakanyanya thymus index, kuwanda kwespleen T neB lymphocytes uye phagocytosis yeperitoneal macrophages;Pa59 mg/kg, yakawedzera zvakanyanya kuwanda kwespleen T uye B lymphocytes uye phagocytosis ye peritoneal macrophages.Hypericin pachiyero che 50 ~ 6.25 ml in vitro inogona kukurudzira zvakanyanya kupararira kwepleen T uye B lymphocytes uye kuwedzera kukwanisa kweT lymphocytes kubudisa IL-2;Hypericin pa 6.25 g / ml yakawedzera zvakanyanya kugona kwembeva peritoneal macrophages kuti phagocytize neutrophils, kubva 12.5 kusvika 3.12 μ G / ml zvakanyanya kuwedzera kugona kwembeva peritoneal macrophages kuburitsa Nha.
Antidepressant effect
Hypothalamic pituitary adrenal (HPA) activation ndiyo inowanzoitika shanduko yehupenyu muvarwere vane kuora mwoyo kwakanyanya, iyo inoratidzwa nekunyanya kuvharwa kwe adrenocorticotropic hormone (ACTH) uye cortisol.Hypericin inogona kugadzirisa basa reHPA axis uye kuderedza mazinga e ACTH uye corticosterone, kuitira kuti uite basa rekudzivirira.
Yakapera Mushonga
Ciwujia capsule
Acanthopanax senticosus capsule gadziriro ine Acanthopanax senticosus hunde uye mashizha anobviswa seyakabikwa.Chinhu chikuru chinonzi flavonoids, umo hypericin ndiyo inonyanya kushanda chikamu cheAcanthopanax senticosus mashizha.
Zviratidzo zvikuru: kukurudzira kutenderera kweropa uye kubvisa stasis yeropa.Inoshandiswa pachipfuva arthralgia uye chirwere chemoyo chinokonzerwa neropa stasis.Zviratidzo zvinosanganisira kurwadziwa muchipfuva, kusimba kwechifuva, kurohwa nehana, hypertension, nezvimwewo ndezvekushomeka kwespleen uye itsvo uye stasis yeropa uye Yin.
Xinan capsule
Iro gadziriro yakagadzirwa nemashizha ehawthorn, ane hupfumi mu flavonoids, umo hypericin chimwe chezvikamu zvikuru.
Zviratidzo zvikuru: kuwedzera coronary cardiovascular system, kuvandudza myocardial ropa uye kuderedza lipid yeropa.Inoshandiswa kurapa chirwere chemwoyo, angina pectoris, kuoma kwechipfuva, palpitation, hypertension, nezvimwewo.
Qiyue Jiangzhi tablet
Qiyue Jiangzhi piritsi mushonga chaiwo wechiChinese mushonga wekudzikisa lipid wakagadzirirwa nekubvisa zvikamu zvinoshanda zvemushonga wechiChinese sehawthorn (enucleated) uye Astragalus membranaceus.Chimwe chezvikamu zvakakosha zvehawthorn ndeye flavonoids, umo hypericin content yakakwirira.
Main zviratidzo: kuderedza ropa lipid uye kupfavisa tsinga dzeropa.Inoshandiswa kuwedzera kutenderera kweropa uye kurwisa arrhythmia uye hyperlipidemia.
Xinxuening tablet
Xinxuening piritsi gadziriro yemukomboni yakagadzirwa nemishonga yechivanhu yechiChinese yakadai sehawthorn uye pueraria.Hawthorn ndiwo mushonga wepamutemo wepati yedu.Iine ursolic acid, Vitexin rhamnoside, hypericin, citric acid, nezvimwewo, iyo hypericin ndiyo chikamu chikuru.
Zviratidzo zvikuru: kukurudzira kutenderera kweropa uye kubvisa stasis yeropa, dredging collaterals uye kubvisa marwadzo.Inoshandiswa pachipfuva arthralgia uye vertigo inokonzerwa nemoyo weropa stasis uye uropi collaterals, pamwe chete nechirwere chemwoyo, hypertension, angina pectoris uye hyperlipidemia.
Yukexin capsule
Yukexin capsule gadziriro yechinyakare yemishonga yeChinese yakagadzirwa kubva kune yakare, iyo inoumbwa neHypericum perforatum, wild jujube kernel, Albizzia bark, Gladiolus nemimwe mishonga yechivanhu yekuChina.Inonyanya kuve ne hypericin, quercetin, quercetin, chlorogenic acid, caffeic acid, yimaning, hypericin uye zvimwe zvikamu.
Zviratidzo zvikuru: kuora mwoyo kwepfungwa kunokonzerwa nekusagadzikana kwechiropa qi uye mafungiro asina kunaka.
