Isoliquiritin Apioside
Kushandiswa kweIsoliquiritin Apioside
Isoliquiritin apioside, chikamu chakaparadzaniswa kubva kuglycorrhizae radio rhome, yakaderedza zvakanyanya PMA inokonzera kuwedzera kweMMP9 basa uye inhibited PMA yakakonzera MAPK uye NF- κ B activation.Isoliquitin apioside inhibits kupinda uye angiogenesis yekenza masero uye endothelial masero.
Zita reIsoliquiritin Apioside
Chinese Name:Isoliquiritin Apioside
Chirungu Zita:(E) -3- [4- [(2S,3R,4S,5S,6R)-3- [(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl] oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-1-(2,4-dihydroxyphenyl)prop-2-en-1-one
Bioactivity yeIsoliquiritin Apioside
Tsanangudzo:isoliquitin apioside, chikamu chakaparadzaniswa neglycorrhizae radio rhome, zvakanyanya kuderedza PMA inokonzera kuwedzera kweMMP9 basa uye inhibited PMA yakakonzera MAPK uye NF- κ B activation.Isoliquitin apioside inhibits kupinda uye angiogenesis yekenza masero uye endothelial masero.
RelatedCzvikamu:research field > > cancer
Signal nzira>> MAPK / ERK chiratidzo nzira>> p38 MAPK
Chiratidzo nzira>> metabolic enzyme / protease>> MMP
Target:MMP9
NF-κB
p38 MAPK
In vitro kudzidza:isorlicin inogona kunyatso kuvharidzira gelation MMP-9 chiitiko chePMA chakakonzera HT1080 masero.Isoglycyrrhizin apigenin inoderedza kuwedzera kweMMP-9 kugadzirwa muHT1080 masero anokonzerwa nePMA, ane simba re anti metastasis uye anti angiogenesis mumasero akaipa emamota uye endothelial masero, uye haana cytotoxicity [1].
Reference:[1].Kim A1, nevamwe.Isoliquiritin Apioside Inodzvinyirira in vitro Invasiveness uye Angiogenesis yeCancer Cells uye Endothelial Cells.Front Pharmacol.2018 Dec 10;9:1455.
Physicochemical properties yeIsoliquiritin Apioside
Density: 1.6 ± 0.1 g / cm3
Poindi yekubikira: 901.0 ± 65.0 ° C pa760 mmHg
Molecular formula: c26h30o13
Molecular uremu: 550.509
Flash point: 301.9 ± 27.8 ° C
Chaizvo misa: 550.168640
PSA:215.83000
LogP:1.96
Kutsiga kwemhepo: 0.0 ± 0.3 mmHg pa25 ° C
Refractive index: 1.709
Chirungu alias yeIsoliquiritin Apioside
2-Propen-1-one,1-(2,4-dihydroxyphenyl)-3--[4--[[2-O-[(2S,3R,4R))-tetrahydro-3,4-dihydroxy-4-(hydroxymethyl )-2-furanyl]-β-D-glucopyranosyl]oxy]phenyl]-, (2E)-
3-[(1E)-3-(2,4-Dihydroxyphenyl)-3-oxo-1-propen-1-yl]phenyl 2-O-[(2S,3R,4R)-3,4-dihydroxy-4 -(hydroxymethyl)tetrahydro-2-furanyl]-β-D-glucopyranoside
Neolicuroside
