Jujuboside A CAS No. 55466-04-1
Ruzivo Rwakakosha
Chinese alias:jujube kernel saponin A, jujube kernel saponin A;Jujube kernel saponin A (yakajairwa)
Zita rechirungu:Jujuboside A
Plant source:inobva mumhodzi dzemusango, dzinozivikanwawo sejujube kernel uye wild jujube core
Molecular formula:C58H94O26
Molecular uremu:1207.35
CAS Nha.55466-04-1
Bioactivity yeJujuboside A
Chinangwa:GABA receptor, mTOR, PI3K, Akt [1] [2]
In vitro kudzidza:low dose 41 μ Jujuboside A yeM (inenge 0.05 g / L) yakakonzera GABA (a) receptors panguva ye24 uye 72 h kurapwa α 1, α 5, β 2 subunit mRNA yakawedzera zvakanyanya.High dose 82 μ M (inenge 0.1 g / L) Jujuboside A yakawedzera zvakanyanya GABA (a) receptors pa24 h α 1, α 5 subunit mRNA mazinga uye yakaderera β 2 subunit mRNA level uye yakaderera GABA (a) receptor subunit α 1, β 2 mRNA kutaura kwakabatwa pa72 h [1].Jujuboside A pretreatment inogona kudzoreredza kuderera kwesero kushanda uye zvirinani kukurudzira ISO yakakonzera H9c2 cell kukuvara.Jujuboside A inogona kumhanyisa phosphorylation yePI3K, Akt uye mTOR.Jujuboside A inogona kuderedza zvakanyanya chikamu che microtubule yakabatana protein LC3-II / I muH9c2 masero [2]
In vivo kudzidza:masikati (9:00-15:00), jujubosides yakawedzera zvakanyanya kurara kwese uye kukurumidza kufamba kwemaziso (REM) kurara, asi haina mhedzisiro yakakosha pakurara kwenon REM (NREM).Husiku (21:00-3:00), jujubosides yakawedzera zvakanyanya kurara kwese uye kurara kweNREM, kunyanya kurara zvishoma, asi hazvina kukosha pakurara kweREM uye kunonoka kwekurara (SWS) [3].Intraventricular treatment nejjuboside a yakaderedzwa zvakanyanya ne kuburikidza neY-maze, kushingaira kudzivirira uye Morris water maze zviyero β 1-42 yakakonzera kudzidza uye kukanganisa kwendangariro mumakonzo.Intracerebroventricular injection yeJujuboside A yakaderera hippocampal a β 1-42 mazinga akadzivisa zvakanyanya mabasa eacetylcholinesterase (AChE) uye kwete, uye yakaderedza kuwedzera kwehuwandu hwemalondialdehyde (MDA) mu hippocampus uye cerebral cortex yemakonzo injected mu lateral β1. [4].
Sero kuedza:mushure memazuva manomwe etsika mu vitro, masero aigara achiratidzwa kwemaawa 24 kana maawa 72, uye haana kuratidzwa kune svikiro rine Jujuboside A kana diazepam kana zvese zviri zviviri.Vector yakawedzerwa kuboka rekutonga;Diazepam boka rakawedzera 10 μ M diazepam;Jujuboside A82 μ M (inenge 0.1g / L) uye 41 μ M (inenge 0.05 g / L) yakawedzerwa kumapoka ejua-h (yakanyanya kuwanda Jujuboside A) nejua-l (yemwero wakaderera Jujuboside A) zvikwata zvichiteerana.Yese RNA yakaparadzaniswa kubva kumaseru kuti iwedzere kuongororwa [1].
Kuedza kwemhuka:mbeva: a akaiswa jekiseni kuburikidza neICV β 1-42 yakakonzera kukanganisa kwekuziva mumakonzo.Zvadaro, mbeva dzakabayiwa neJujuboside A (0.02 uye 0.2 mg / kg) intraventricular (ICV) kwemazuva mashanu.Y maze, kushingaira kudzivirira uye Morris mvura maze miedzo yakaitwa pamakonzo [1].
Zita reChirungu reJujuboside A
α-L-arabinopyranoside, (3β,16β,23R)-16,23:16,30-diepoxy-20-hydroxydammar-24-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O-[O-β-D-glucopyranosyl-(1->6)-O-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->3 )]-
(3β,16β,23R)-20-Hydroxy-16,23:16,30-diepoxydammar-24-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)--[β-D -glucopyranosyl-(1->6)-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->3)]-α -L-arabinopyranoside
jujuboside C
α-L-Arabinopyranoside, (3β,16β,23R)-16,23:16,30-diepoxy-20-hydroxydammar-24-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O-[O-β-D-glucopyranosyl-(1->6)-O-[β-D-xylopyranosyl-(1->2)]- β-D-glucopyranosyl-(1->3 )]-
JujubosideA
(3β,16β,23R)-20-Hydroxy-16,23:16,30-diepoxydammar-24-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)--[β-D -glucopyranosyl-(1->6)-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->3)]-α-L-arabinopyranoside
