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Naringin ndiyo aglycone ye naringin uye ndeye dihydroflavonoids.Iine mabasa eantibacterial, anti-inflammatory, free radical scavenging, antioxidant, kukosora uye expectorant, ropa lipid kuderedza, anti-cancer, anti-tumor, antispasmodic uye cholagogic, kudzivirira uye kurapwa kwezvirwere zvechiropa, inhibition ye platelet coagulation, anti. atherosclerosis uye zvichingodaro.Inogona kushandiswa zvakanyanya mumishonga, chikafu uye mamwe minda.

Antibacterial
Iine yakasimba antibacterial effect paStaphylococcus aureus, Escherichia coli, dysentery uye typhoid bacillus.Naringin zvakare ine mhedzisiro pane fungi.Kumwaya 1000ppm pamupunga kunogona kuderedza utachiona hweMagnaporthe grisea ne40-90%, uye hakuna chepfu kuvanhu nezvipfuyo.

Antiinflammatory
Makonzo akaiswa intraperitoneally jekiseni ne 20mg / kg zuva rega rega, izvo zvakanyanya kuvharidzira maitiro ekuzvimba anokonzerwa nemvere dzebhora kuisirwa.VaGaratia nevamwe.Yakaona kuti rimwe nerimwe boka repiritsi renaringin rine anti-inflammatory effect kuburikidza ne mouse ear tablet kuedza, uye anti-inflammatory effect yakawedzera nekuwedzera kwedosi.The inhibition rate yeboka repamusoro redosi yaive 30.67% ine ukobvu musiyano uye 38% ine uremu musiyano.[4] Feng Baomin et al.Induced phase 3 dermatitis mumakonzo neDNFB nzira, uye ndokupa naringin nemuromo kwemazuva 2 ~ 8 kuti ione inhibition mazinga eiyo immediate phase (IPR), late phase (LPR) uye Ultra late phase (VLPR).Naringin inogona kunyatso kuvharidzira nzeve edema yeIPR neVLPR, uye ine humwe kukosha kwekusimudzira mukurwisa-kuzvimba.

Kudzorwa kwemmune
Naringin inochengetedza kuenzana kwakakodzera kweoxidative pressure munguva chaiyo uye matunhu chaiwo nekugadzirisa mafambiro emaerekitironi mumitochondria.Naizvozvo, iyo immunomodulatory basa re naringin rakasiyana kubva kune echinyakare akareruka immune ekuwedzera kana immunosuppressants.Chimiro chayo ndechekuti inogona kudzoreredza iyo isina kuenzana immune system (pathological state) kune iri pedyo yakajairika immune balance state (physiological state), Panzvimbo pekuwedzera unilaterally kana kuvharidzira mhinduro yekudzivirira.

Kugadziriswa kwevakadzi kumwedzi
Naringin ine chiitiko chakafanana neisiri steroidal anti-inflammatory drugs.Inogona kuderedza kuumbwa kwe prostaglandin PGE2 nekudzivisa cyclooxygenase Cox, uye kutamba basa re antipyretic, analgesic uye kuderedza kuzvimba.
Zvichienderana neestrogen semhedzisiro yenaringin, naringin inogona kushandiswa estrogen kutsiva kurapa muvakadzi vane postmenopausal kudzivirira kukanganisa kwakakomba kunokonzerwa nekushandiswa kwenguva refu kweesrogen.

Migumisiro pakufutisa
Naringin ine pachena kurapa mhedzisiro pane hyperlipidemia uye kufutisa.
Naringin inogona kuvandudza zvakanyanya plasma cholesterol concentration, TG (triglyceride) concentration uye yemahara fatty acid concentration mumakonzo akafuta.Zvakaonekwa kuti naringin inogona kusimudza kudzora monocyte peroxisome proliferator activated receptor mune yakakwirira-mafuta muenzaniso makonzo δ, Kuderedza ropa lipid level.
Kuburikidza nemiedzo yekiriniki, zvakaonekwa kuti varwere vane hypercholesterolemia vakatora imwe capsule ine 400mg naringin zuva rega rega kwemavhiki masere.Mamiriro eTC uye LDL cholesterol muplasma yakaderera, asi kuwanda kweTG uye HDL cholesterol hakuna kuchinja zvakanyanya.
Mukupedzisa, naringin inogona kuvandudza hyperlipidemia, iyo yakanyatsosimbiswa mukuedza kwemhuka uye miedzo yekiriniki.

Kubvisa mahara radicals uye antioxidation
DPPH (dibenzo bitter acyl radical) inogadzikana mahara radical.Kugona kwayo kuburitsa mahara radicals inogona kuongororwa neiyo 517 nm absorbance attenuation.[6] Kroyer akadzidza antioxidant effect ye naringin kuburikidza nekuedza uye akasimbisa kuti naringin ine antioxidant effect.[7] Zhang Haide et al.Yakaedza maitiro e lipid peroxidation yeLDL ne colorimetry uye kugona kuvharidzira oxidative shanduko yeLDL.Naringin inonyanya chelates Cu2 + kuburikidza ne3-hydroxyl uye 4-carbonyl mapoka, kana inopa proton uye mahara radical neutralization, kana inodzivirira LDL kubva lipid peroxidation kuburikidza wega oxidation.Zhang Haide nevamwe vakawana kuti naringin ine yakanaka yemahara radical scavenging maitiro neDPPH nzira.Iyo yemahara radical scavenging athari inogona kuitika neiyo hydrogen oxidation ye naringin pachayo.[8] Peng Shuhui et al.Yakashandisa yekuedza modhi yechiedza riboflavin (IR) - nitrotetrazolium chloride (NBT) - spectrophotometry kuratidza kuti naringin ine pachena scavenging pesvedzero pamusoro reactive okisijeni mhando O2 -, iyo yakasimba kupfuura iyo ascorbic asidhi mukutonga kwakanaka.Mhedzisiro yeongororo yemhuka yakaratidza kuti naringin yaive nesimba rekudzivisa lipid peroxidation muuropi hwembeva, moyo uye chiropa, uye inogona kuwedzera zvakanyanya basa re superoxide dismutase (SOD) muropa rose rembeva.

Kudzivirirwa Kwemoyo
Naringin uye naringin zvinogona kuwedzera mabasa eacetaldehyde reductase (ADH) uye acetaldehyde dehydrogenase (ALDH), kuderedza zviri mukati me triglycerides muchiropa uye cholesterol yose muropa uye chiropa, kuwedzera zvinyorwa zve high density lipoprotein cholesterol (HDLC), kuwedzera chiyero. yeHDLC kune yakazara cholesterol, uye kuderedza atherogenic index panguva imwe chete, Naringin inogona kukurudzira kutakurwa kwecholesterol kubva muplasma kusvika kuchiropa, bile secretion uye excretion, uye inhibit kuchinja kweHDL kuVLDL kana LDL.Naizvozvo, naringin inogona kuderedza njodzi yearteriosclerosis uye chirwere chemwoyo.Naringin inogona kuderedza zvemukati cholesterol yakazara muplasma uye kusimbisa metabolism yayo.

Hypolipidemic Mhedzisiro
Zhang Haide et al.Yakaedzwa serum cholesterol (TC), yakaderera density lipoprotein cholesterol (LDL-C), plasma yakakwira density lipoprotein cholesterol (HDL-C), triglyceride (TG) nezvimwe zvinhu zvembeva mushure mekutonga kwemutsinga kuburikidza nekuedza kwemhuka. serum TC, TG uye LDL-C uye inowedzera serum HDL-C pane imwe dosi, zvichiratidza kuti naringin yaive nemhedzisiro yekudzikisa lipid yeropa mumakonzo.[

Antitumor Chiitiko
Naringin inogona kudzora mashandiro emuviri uye inhibit bundu kukura.Naringin ine chiitiko pane rat leukemia L1210 uye sarcoma.Mhedzisiro yacho yakaratidza kuti huremu hwehuremu hwehuremu hwemakonzo hwakawedzera mushure mekutonga nemuromo kwe naringin, zvichiratidza kuti naringin inogona kuwedzera immune system yemuviri.Naringin inogona kudzora mwero weT lymphocytes, kugadzirisa chechipiri kushomeka kwemuviri kunokonzerwa nebundu kana radiotherapy uye chemotherapy, uye kuwedzera kuuraya mhedzisiro yekenza maseru.Zvinonzi naringin inogona kuwedzera huremu hwe thymus mu ascites cancer inotakura mbeva, zvichiratidza kuti inogona kusimudzira immune immune uye kuunganidza yayo yemukati anti-cancer kugona.Zvakaonekwa kuti pomelo peel inobvisa ine inhibitory mhedzisiro paS180 sarcoma, uye bundu inhibition rate yaive 29.7%.

Antispasmodic uye cholagogic
Iine simba rakasimba mu flavonoids.Naringin zvakare ine simba rakasimba pakuwedzera bile secretion yemhuka dzekuyedza.

Antitussive uye Expectorant Mhedzisiro
Kushandisa phenol tsvuku sechiratidzo chekubvisa chirwere, kuedza kunoratidza kuti naringin ine chikosoro chakasimba uye expectorant effect.

Clinical Application
Inoshandiswa kurapa hutachiona hwehutachiona, sedative uye anticancer mishonga.
Chikumbiro chipiro fomu: suppository, lotion, jekiseni, piritsi, capsule, etc.