Ophiopogonin D Cas No.945619-74-9
Ophiopogon Saponin D Zita
Chirungu Zita:(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)] -6-deoxy-β-D-galactopyranoside
Bioactivity yeOphiopogon Japonicus Saponin D
Tsanangudzo:Ophiopogon D isingawanzoitiki yakasikwa C29 steroidal glycoside yakaparadzaniswa kubva kune tuber yeOphiopogon japonicus.Ophiopogonin D ndeye CYP2J3 inducer inowedzera CYP2J2 / eets uye PPAR mumunhu umbilical vein endothelial masero (HUVECs) α Kutaura kweAng II kwakadzivisa zvakanyanya Ang II yakakonzera NF- κ B nuclear translocation, I κ B α Down regulation, intracellular Ca2 + kuwandisa uye kushandiswa kweproinflammatory cytokines.Ophiopogonin D yakashandiswa kurapa kuzvimba uye zvirwere zvemoyo kwezviuru zvemakore.
Zvikamu Zvakakodzera
Chiratidzo nzira>> transmembrane transport>> calcium chiteshi
Tsvagiridzo > > chirwere chemoyo
Kuratidzira nzira>> kutenderera kwesero / DNA kukuvadzwa>> PPAR
Tsvagiridzo yemunda > > kuzvimba / kusadzivirirwa
Target
PPARα
NF-κB
Ca2+
Reference Documents:[1].Wang L, nevamwe.Homo-aro-cholestane, furostane uye spirostane saponins kubva kumachubhu eOphiopogonjaponicus.Phytochemistry.2017 Apr;136:125-132.
[2].Huang X, nevamwe.Ophiopogonin D uye EETs inonatsiridza Ang II-induced kuzvimba mhinduro kuburikidza ne activating PPARα muHUVECs.Biochem Biophys Res Commun.2017 Aug 19;490(2):123-133.
Chirungu Alias of Ophiopogon saponin D
(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)] -6-deoxy-β-D-galactopyranoside β-D-Galactopyranoside, (1β,3β,25R) -3-hydroxyspirost-5-en-1-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O-[β-D-xylopyranosyl-(1->3)]-6-deoxy-
(2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-5-hydroxy-2-((((4R,5'R,6R,6aR,6bS,8aS) ,8bR,9S,10R,11aS,12aS,12bS)-4-hydroxy-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a, 6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2 '-pyran]-6-yl)oxy)-6-methyl-4-(((2S,3R,4S,5R) -3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydro- 2H-pyran-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol
Ophiopogonin D
Deacetylophiopogonin C
