Alaabta

Sharaxaad:monoammonium glycyrrhizinate hydrate waxay leedahay hawlo dawooyin ah sida ka hortagga bararka, xasaasiyadda ka hortagga, boogaha caloosha iyo cagaarshowga ka hortagga.

Qaybaha la xidhiidha:
jidka signal > > kale > > kale
Goobta cilmi-baarista > > caabuq / difaac

Barashada Vivo:korodhka sambabada w / D miisaanka miisaanka ayaa si weyn hoos ugu dhacay maamulka qiyaasta sare iyo dhexdhexaad ah ee mag (10 iyo 30 mg / kg).Ka-hortagga mag (10 iyo 30 mg / kg) ayaa si wax ku ool ah hoos ugu dhigay TNF-α Iyo IL-1 β Generation of.Mag (10,30 mg / kg) ayaa si weyn hoos ugu dhacay NF marka la barbar dhigo LPS-κ Bp65 muujinta borotiinka.Taas bedelkeeda, LPS waxay si weyn hoos ugu dhigtay I marka la barbardhigo kooxda kantaroolka κ B- α Protein muujinta, halka mag (10 iyo 30 mg / kg) ay si weyn u korodhay I κ B- α Expression [1].Marka la barbardhigo kooxaha RIF iyo INH, daawaynta MAG ee qiyaasta hoose iyo qiyaasta sare waxay si weyn hoos ugu dhigtay ast, alt, TBIL iyo heerarka TBA ee 14 iyo 21 maalmood, taas oo muujinaysa saameynta ilaalinta MAG ee RIF - iyo INH -.Keen dhaawaca beerka.Kooxda daawaynta MAG waxay kordhisay heerka GSH ee beerka ee 7, 14 iyo 21 maalmood, waxayna si weyn hoos ugu dhacday heerka MDA ee 14 iyo 21 maalmood ee RIF iyo INH jiirka la daweeyay, taas oo muujinaysa saamaynta ilaalinta MAG ee RIF - iyo.INH ay sababtay dhaawaca beerka [2].

Tijaabada Xoolaha:jiirarka [1] daraasaddan, BALB / c jiirarka (lab, 6-8 toddobaad jir ah, 20-25g) ayaa la isticmaalay.Jiirarka ayaa si aan kala sooc lahayn loo qaybiyay 5 kooxood: kooxda xakamaynta, kooxda LPS iyo LPS + monoammonium glycyrrhizinate (Mag: 3,10 iyo 30mg / kg).Koox kastaa waxay ka koobnayd 8 jiir.Jiirarka ayaa lagu suuxiyay duritaanka intraperitoneal ee pentobarbital sodium (50 mg / kg).Jiirarka ayaa lagu duray intraperitoneal mag (3, 10 iyo 30 mg / kg) ka hor intaysan keenin dhaawac sambabada oo ba'an.1 saac kadib, LPS (5 mg/kg) ayaa lagu duray intratracheal si loo keeno dhaawac sambabada oo ba'an.Jiirarka caadiga ah ayaa la siiyay PBS [1].Jiirka [2] waxay isticmaaleen jiirka Wistar ee lab ah (180-220g).Jiirka ayaa si aan kala sooc lahayn loo kala qaybiyay 4 kooxood: kooxda kantaroolka, kooxda RIF iyo INH, MAG kooxda qiyaas yar iyo kooxda qiyaasta sare ee MAG, oo leh 15 jiir koox kasta.Jiirka ee kooxaha RIF iyo INH waxaa la siiyay RIF (60mg / kg) iyo INH (60mg / kg) gavage hal mar maalintii;Jiirka kooxda MAG waxaa lagu daaweeyay MAG ee qiyaasta 45 ama 90 mg / kg, iyo RIF (60 mg / kg) iyo INH (60 mg / kg) ayaa la siiyay 3 saacadood ka dib maamulka MAG;Jiirka kooxda xakamaynta waxaa lagu daaweeyay cusbo caadi ah.Si loo qiimeeyo saameynta firfircoon ee daroogada, jiirarka koox kasta ayaa la dilay 7, 14 iyo 21 maalmood ka dib maamulka [2].

Tixraac:1].Huang X, iyo al.Saamaynnada Ka-hortagga bararka ee Monoammonium Glycyrrhizinate ee Lipopolysaccharide-ku-Dhaawac-Ba'an ee Sambabka ee Jiirarka iyada oo loo marayo Nidaaminta Qodobbada Nukliyeerka-Kappa B Waddada Calaamadeynta.Evid Based Complement Alternat Med.2015;2015:272474.
[2].Zhou L, iyo al.Monoammonium glycyrrhizinate waxay ilaalisaa rifampicin- iyo hepatotoxicity isoniazid-ku keeno iyada oo la xakameynayo muujinta gaadiidka Mrp2, Ntcp, iyo Oatp1a4 ee beerka.Pharm Biol.2016;54 (6):931-7.