Astragaloside IV CAS No. 84687-43-4
Hordhac Kooban
Magaca Ingiriisiga:Astragaloside IV;beta-D-Glucopyranoside, (3beta,6alpha,16beta,24R) -20,24-epoxy-16,25-dihydroxy-3-(beta-D-xylopyranosyloxy) -9,19-cyclolanostan-6-yl;(3beta,6alpha,9beta,16beta,20R,24S)-16,25-dihydroxy-3-(beta-D-xylopyranosyloxy)-20,24-epoxy-9,19-cyclolanostan-6-yl beta-D-threo - hexopyranoside
Qaacidada Molecular:C41H68O14
Magaca Kiimikada:17-[5-(1-Hydroxyl-1-methyl-ethyl)- 2methyl-tetrahydro- furan-2-yl] -4,4,13,14-tetramethyl-tetradecahydro-cyclopropa[9,10]cyclopenta[a] phenanthren-16-ol-3-β-D-aracopyranosyl-6-β-D- glucoside
Mp:200-204 ℃
[α]D:-56.6 (c,0.13 gudaha DMF)
UV:ugu badnaan 203 nm
daahirnimo98%
Xigasho:legume Astragalus membranaceus, Astragalus pubescens.
Qaab dhismeedka kiimikada ee astragaloside IV
Tilmaamaha Kiimikaad
[muuqaalka]:budo crystalline cad
[nadiifin]:ka sarreeya 98%, habka ogaanshaha: HPLC
[Isha dhirta]:Xididdada Astragalus Alexandrinus Boiss, Astragalus dissectus, Astragalus membranaceus (Fisch.) Xididka Bungede, Astragalus sieversianus Pall Root of Astragalus spinosus Vahl, qaybta hawada ee Astragalus spinosus Vahl.
[product properties]:Soosaaray Astragalus membranaceus waa budada jaalaha ah ee brown.
[content determination]:waxaa go'aamiya HPLC (Lifaaqa VI D, Mugga I, Farmashiyaha Shiinaha, Daabacaadda 2010).
Xaaladaha Chromatographic iyo Imtixaanka ku habboonaanta nidaamka} octadecyl silane bonded silica jel waxa loo isticmaalaa buuxin ahaan, biyaha acetonitrile (32:68) waxa loo istcimaalaa weji moobil ahaan, iyo uumi firdhiso iftiinka iftiinka ayaa loo isticmaalaa ogaanshaha.Tirada taarikada aragtida waa inaysan ka yarayn 4000 marka loo eego astragaloside IV ugu sarreeya.
Diyaarinta xalka tixraaca, qaado qadar ku habboon tixraaca astragaloside IV, si sax ah u miisaamee, ku dar methanol si aad u diyaariso xal ka kooban 0.5mg halkii 1ml.
Diyaarinta xalka tijaabada:ka soo qaado 4G oo budo ah alaabtan, si sax ah u miisaan, ku rid Soxhlet extractor, ku dar 40ml oo methanol ah, qoysid habeen, ku dar qadar ku haboon oo methanol ah, kulayl iyo reflux 4 saacadood, ka soo kabso dareeraha ka soosaarkii oo xooga saar Si aad u qallajiso, ku dar 10ml oo biyo ah si aad u milanto haraaga, rux oo ku soo saar n-butanol buuxa 4 jeer, 40ml mar kasta, ku dar xal n-butanol, oo si buuxda ugu dhaq xal tijaabada ammonia 2 jeer, 40ml kasta waqti, iska tuur xalka ammonia, uumi-milaha n-butanol, ku dar 5ml biyo ah si ay u milmaan haraaga, oo qaboojiso, Iyada oo loo marayo D101 tiir adsorption resin adsorption (dhexroorka gudaha: 37.5px, column height: 300px), elute leh 50ml oo biyo ah , iska tuur xalalka biyaha, 30ml oo 40% ethanol ah, iska tuur 80ml ee 70% ethanol, ururiya illaha, u soo bax si ay u engegaan, ku milaan haraaga methanol, ku wareeji weel 5ml ah, ku dar. methanol ilaa miisaanka, si fiican u rux, iyoka dibna qaado.
Habka go'aaminta:si sax ah u nuugo 10% ee xalka tixraaca siday u kala horreeyaan μ l, 20 μl.Tijaabi xal 20 μl kasta.Ku duri chromatograph-ka dareeraha ah, go'aami, oo ku xisaabi isla'egta logarithm-ka ee habka laba-dhibcood ee caadiga ah ee dibadda.
Waxaa loo xisaabiyaa sida badeecada qalalan, waxa ku jira astragaloside IV (c41h68o14) waa inaysan ka yarayn 0.040%
Falka dawooyinka
Qaybaha ugu muhiimsan ee waxtarka leh ee Astragalus waa polysaccharides iyo astragaloside.Astragaloside waxaa loo qaybiyaa astragaloside I, astragaloside II iyo astragaloside IV.Waxaa ka mid ah, astragaloside IV, astragaloside IV, ayaa leh dhaqdhaqaaqa bayoolojiga ugu fiican.Astragaloside IV ma aha oo kaliya saamaynta Astragalus polysaccharides, laakiin sidoo kale qaar ka mid ah saamaynta aan la barbar dhigi karin ee Astragalus polysaccharides.Xoojinta waxtarkeedu waa in ka badan laba jeer kan astragalus polysaccharides caadiga ah, saameynteeda fayraska waa 30 jeer ka badan Astragalus polysaccharides.Sababtoo ah maadada hoose iyo saamaynta wanaagsan, waxaa sidoo kale loo yaqaan "super astragalus polysaccharide".
1. Kor u qaad difaaca iyo iska caabbinta cudurada.
Waxay si gaar ah iyo si gaar ahba uga saari kartaa hay'adaha ajnabiga ah ee ku soo duulaya jidhka, waxay kor u qaadi kartaa difaac gaar ah, difaac ah iyo kuwo aan gaar ahayn, waxayna wanaajisaa iska caabbinta cudurka ee jirka.Waxay kor u qaadi kartaa soosaarka antibody-ka, waxayna si weyn u wanaajin kartaa tirada unugyada unugyada unugyada difaaca jirka iyo qiimihii tijaabada hemolysis.Astragaloside IV waxay si weyn u wanaajin kartaa heerka isbeddelka lymphocyte iyo heerka samaynta E-rosette ee digaagga la tallaalay coccidia.Waa firfircooni wax ku ool ah ee nidaamka macrophage monocyte.Astragaloside IV waxay sidoo kale hagaajin kartaa oksaydhka, GSH-Px iyo SOD ee xubnaha difaaca jirka, waxayna wanaajisaa difaaca difaaca iyo hawlaha ilaalinta difaaca.
2.saamaynta fayraska.
Mabda'a ka hortagga fayraska: waxay kicisaa shaqada macrophages iyo unugyada T, waxay kordhiyaan tirada E-ring ee samaynta unugyada, waxay kiciyaan cytokines, kor u qaadista interleukin, waxayna ka dhigaan jidhka xayawaanka inuu soo saaro interferon endogenous, si loo gaaro ujeedada ka hortagga fayraska.Natiijooyinku waxay muujiyeen in wadarta guud ee ilaalinta astragaloside IV ee IBD ay ahayd 98.33%, taas oo si wax ku ool ah uga hortagi karta loona daweyn karo IBD, mana jirin farqi weyn oo la barbar dhigo xalka ukunta difaaca ee sare.Astragaloside waxay kor u qaadi kartaa shaqada enzymes-ka antioxidant-ka ee jirka, waxay yaraynaysaa nuxurka LP0, waxay yaraynaysaa dhaawaca noocyada ogsijiinta falcelinta, oo sidaas awgeed hoos u dhigta heerka dhacdooyinka iyo dhimashada MD.Waxay hagaajin kartaa shaqada difaaca hooseeya ee ay keento burada, kor u qaaddo firfircoonida unugyada difaaca jirka, sii daaya arrimo endogenous, iyo ka hortagga dilka iyo xakameynta unugyada burooyinka ee ay keento peroxidation;Astragaloside a waxay joojin kartaa koritaanka fayraska hargabka iyo dhaqdhaqaaqa sialidase.Waxay saameyn weyn ku leedahay shaqada xuubabka unugga fayraska hargabka iyo u dhexgalka iyo dhexgalka fayraska unugyada xasaasiga ah.Heerka dhimashada iyo ukunta ukunta digaaga ayaa si weyn loo dhimay, heerka ugxanta ukunta iyo soo kabashada tayada ukunta ayaa si aad ah uga wanaagsan kuwa ka mid ah kooxda kantaroolka amantadine kaliya, iyo saameynta Astragalus polysaccharide ma ahayn mid cad;Astragaloside IV waxay leedahay dil xoog leh iyo saameyn ka hortag ah fayraska.Ujeeddadu waxay tahay in isticmaalka astragaloside IV uu yahay ka hor inta aan la helin caabuqa Nd fayraska, sidaa daraadeed waxa ugu wanaagsan in la isticmaalo astragaloside IV muddo dheer, Avian myeloblastic leukemia (AMB) 3 maalin jir ah AA broilers ayaa quudin jiray astragaloside IV oo leh caabuqa. Fayraska AMB, wuxuu yarayn karaa heerka dhacdooyinka iyo dhimashada AMB, wuxuu kordhin karaa maadada LPO ee xubnaha difaaca sida beeryarada iyo thymus, waxay si weyn u wanaajisaa saamaynta xoqitaanka beeryarada iyo thymus iyo xubnaha kale ee difaaca ee unugyada burooyinka myeloid.Marka labaad, astragaloside IV waxay leedahay ka hortag cad iyo saameyno daweyn oo ku saabsan cudurrada neefsashada sida laryngotracheitis faafa.Isticmaal
3. Saamaynta walaaca ka hortagga.
Astragaloside IV waxay ka hortagi kartaa hyperplasia adrenal hyperplasia iyo thymus atrophy xilliga digniinta ee jawaab-celinta walaaca, waxayna ka hortagtaa isbeddellada aan caadiga ahayn ee xilliga iska caabbinta iyo xilliga fashilka ee jawaab-celinta walaaca, si ay u ciyaaraan doorka ka hortagga cadaadiska, gaar ahaan waxay leedahay nidaam laba-dhinac ah oo muhiim ah. saamaynta ensaymes ee habka dheef-shiid kiimikaadka nafaqeeyayaalka ah, waxayna yaraynaysaa oo meesha ka saaraysaa saamaynta diiqada kulaylka ee shaqada jir ahaaneed ee jirka ilaa xad.
4. Sida kor u qaadida korriinka.
Waxay kor u qaadi kartaa dheef-shiid kiimikaad ee unugyada, kor u qaadida wareegga dhiigga, kor u qaadida dheef-shiid kiimikaadka jidhka xayawaanka, waxayna ciyaareysaa doorka nafaqada iyo daryeelka caafimaadka.Cilmi-baaristu waxay muujinaysaa inay kor u qaadi karto koritaanka bifidobacteria iyo bakteeriyada lactic acid waxayna leedahay saameynta probiotics.
5. Astragaloside IV waxay hagaajin kartaa shaqada wadnaha sambabada.
Xooji isku laabashada wadnaha, ilaali myocardium oo iska caabbinta wadne xanuunka.Waxa kale oo ay leedahay saamaynta ilaalinta beerka, anti-bararka iyo xanuunka.Waxaa loo isticmaali karaa daawaynta adjuvant cudurada kala duwan ee fayras iyo bakteeriyada.
