Cycloastragenol CAS No. 78574-94-4
Tilmaamaha Alaabta
[name]:khamriga cycloastragalus
[loo yaqaan]:triterpenoid cyclic flavonol
[Magaca Ingiriisiga]:cycloastragenol
[Qaabka kellika ah]:C30H50O5
[miisaanka unugyada]:490.71
[CAS Maya]:78574-94-4
[habka lagu ogaanayo]:HPLC ≥ 98%
[Tilmaan]:20mg 50mg 100mg 500mg 1g (waxaa lagu baakayn karaa si waafaqsan shuruudaha macaamiisha)
[hantida]:alaabtani waa crystal acicular aan midab lahayn
[shaqo iyo isticmaal]:Alaabtan waxa loo isticmaalaa go'aaminta nuxurka, aqoonsiga, tijaabada dawooyinka, baadhista hawsha iyo tijaabooyinka cilmi-baadhista ee kale.Sida maamulka unugyada, tijaabada gastric, kormeerka tayada gudaha ee warshadda dawooyinka, iwm. Source: Astragalus membranaceus (Fisch.) Bge.Xidid qallalan
Habka Kaydinta
2-8 ° C, laga xidhay iftiinka oo lagu kaydiyay heerkul hoose.
Ogow
Alaabtan waa in lagu kaydiyaa heerkul hooseeya.Haddii ay hawada ku jirto muddo dheer, waxa ku jira waa la dhimi doonaa.
Xaaladaha Chromatographic} tiirka chromatographic: Zorbax rx-c18 (4.6mm) × 150mm), 5 μ mHeerka socodka: 1.0ml/min, heerkulka tiirka: 35 ℃, cabbirada ELSD: heerkulka tuubada qulqulaya: 105 ℃, heerka qulqulka nitrogen: 2.70ml/min.
Qalabka kiimikaad: cufnaanta 1.20
Bioactivity ee cycloastragenol
Cycloastragalol waa triterpene saponin, kaas oo ah Astragalus membranaceus (Fisch.) Hydrolyzate ee walaxda firfircoon ee Bunge).Astramembrangenin waxay leedahay badbaado afka ah waxayna leedahay saameyn fara badan oo farmaajo ah, oo ay ku jiraan firfircoonida telomerase, kordhinta telomere, ka hortagga bararka iyo sifooyinka antioxidant.Astramembrangenin waxay leedahay sifooyin ka hortagga gabowga.CAG waxay kicisaa dhaqdhaqaaqa telomerase ee keratinocytes ee bini'aadamka cusub iyo unugyada dareemayaasha jiirka waxayna kicisaa firfircoonida CREB.Astramembrangenin waxaa laga yaabaa inay saameyn daweyn cusub ku yeelato niyad-jabka
Qaybaha khuseeya:
Jidka calaamadaynta > > apoptosis > > apoptosis
Goobta cilmi-baarista > > caabuq / difaac
Goobta cilmi-baarista > Cudurrada neerfaha
Barashada Vitro dhexdeeda:
Marka la barbar dhigo kantaroolka side ee dhaqanka HEK, borotiinka xuubabka xiddigta (0-10 μM; 3-6 maalmood) ayaa kordhay korriinka unugyada [1].Astramembrangenin (0.3 μM;5-90 daqiiqo) waxay keentay fosforyaalka CREB ee neurons-ka asaasiga ah, iyo muujinta wadarta CREB ee labada nooc ee unugyada ma saameynin CAG [1].borotiinka xuubabka xiddigta (3) μ M;6-48 saacadood) waxay kor u qaadi kartaa gudbinta calaamadaha vivo ee neurons, kordhinta muujinta TERT mRNA, oo muujisa korodhka bcl 2 mRNA muujinta [1].Qiimaynta jiritaanka unuggu [1] khadka unugga: U-fiirsashada unugga HEK: 1 μM，3 μM，10 μM waqtiga dhaqanka: 3-6 maalmood natiijooyinka: koritaanka unuggu wuxuu labanlaabmay 6 maalmood.Falanqaynta Western blot [1] khadka unugyada: fiirsashada unugyada neerfaha: 0.3 μM wakhtiga dhaqanka: 5 daqiiqo, 15 daqiiqo, 30 daqiiqo, 90 daqiiqo.Natiijooyinka: CAG waxay keentay firfircoonida CREB ee neerfayaasha.RT-PCR [1] xariiqda unugyada: xoojinta unugyada neerfaha: 3 μM wakhtiga dhaqanka: 6-48 saacadood natiijooyinka: muujinta TERT iyo Bcl 2 mRNA ayaa kordhay.
Tixraac:
[1]Ip FC, iyo al.Cycloastragenol waa firfircooni telomerase awood leh oo ku jira unugyada neerfaha: saameyn ku yeelashada maareynta niyad-jabka.Neurosignals.2014;22 (1):52-63.
[2].Yu Y, iyo al.Cycloastragenol: Musharax sheeko xiiso leh oo loogu talagalay cudurrada da'da la xiriira.Exp Ther Med.2018 Seb;16 (3):2175-2182.
[3]Sun C, iyo al.Cycloastragenol waxay dhexdhexaadisaa firfircoonida iyo xakamaynta faafinta ee koncanavalin A-induced mouse lymphocyte pan-activation model.Immunopharmacol Immunotoxicol.2017 Jun;39 (3): 131-139.
Sifooyinka Kiimikaad ee Cycloastragenol
Cufnaanta:1.2 ± 0.1 g / cm3
Barta karkarinta:617.2 ± 55.0 ° C at 760 mmHg
Barta dhalaalka:241.0 ilaa 245.0 ° C
Qaaciidada molecular:c30h50o5
Miisaanka molecular:490.715
Barta toosan:327.1 ± 31.5 ° C
Tirada saxda ah:490.365814
PSA:90.15000
LogP:3.82
Cadaadiska uumiga:0.0 ± 4.0 mmHg at 25 ° C
Tusmada dib-u-celinta:1.582
Macluumaadka Badbaadada Cycloastragenol
Xeerka gaadiidka ee alaabta khatarta ah: noh ee dhammaan noocyada gaadiidka
Lambarka RTECS;GX8265000
Xeerka Kastamka: 2942000000
Kastamka Cycloastragalol
Xeerka Kastamka: 2942000000
Suugaanta Cycloastragalol
Cycloastragenol waa firfircooni telomerase awood leh oo ku jira unugyada neerfaha: saameyn ku yeelashada maareynta niyad-jabka.
Neurosignals 22 (1), 52-63, (2014)
Cycloastragenol (CAG) waa aglycone of astragaloside IV.Waxaa markii ugu horreysay la aqoonsaday markii la baarayay Astragalus membranaceus soosaarayaasha maaddooyinka firfircoon ee leh sifooyinka gabowga.Daraasadda hadda socota ayaa de...
Dhaqdhaqaaqa cusub ee telomerase activator wuxuu xakameeyaa dhaawaca sambabada ee qaabka xuubka fibrosis ee sambabada.
PLoS ONE 8 (3) , e58423, (2013)
Soo ifbaxa cudurrada la xidhiidha cillad la'aanta telomere, oo ay ku jiraan AIDS, dhiig-yarida aplastic anemia iyo fibrosis sambabada, ayaa xoojiyay xiisaha telomerase activators.Waxaan ka warbixinay aqoonsiga n...
Telomerase-ku-saleysan farmashiyaha kor u qaadida shaqada ka hortagga fayraska ee CD8+ T lymphocytes aadanaha.
J. Immunol.181 (10), 7400-6, (2008)
Telomerase reverse waxa ay ku qortaa DNA telomere cidhifyada koromosoomyada toosan waxayna dib u dhigtaa gabowga gacanta.Si ka duwan inta badan unugyada somatic ee caadiga ah, kuwaas oo muujiya wax yar ama aan lahayn wax-qabad telomerase, difaaca ...
Ingriiska oo loo yaqaan Cycloastragalol
9,19-Cyclolanostane-3,6,16,25-tetrol,20,24-epoxy-,(3β,6α,9β,16β,20R,24S)
Astramembrangenin
(3β,6α,9β,16β,20R,24R) -20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol
19-Cyclolanostane-3,6,16,25-tetrol,20,24-epoxy-,(3β,6α,9β,16β,20R,24R)
(3β,6α,9β,16β,20R,24S)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol
Cyclosieversigenin
Cyclogalegigenin
