Alaabta

Sharaxaad:glucoridin waa isoflavane ka soo jeeda glycorrhiza glabra, kaas oo xidhi kara oo kicin kara PPAR γ, Qiimaha EC50 waa 6115 nm.Glabridin wuxuu leeyahay antioxidant, bakteeriyada, anti glomerulonephritis, anti-sonkorowga, anti-buro, anti-bararka, anti-osteoporosis, ilaalinta wadnaha iyo xididdada, ilaalinta neerfaha, scavenous xagjirka xorta ah iyo hawlo kale.

Qaybaha la xidhiidha:goobta cilmi-baarista > > kansarka
Dariiqa calaamadaynta > > wareegga unugyada / dhaawaca DNA> PPAR
Goobta cilmi-baarista > > caabuq / difaac

Barashada Vitro dhexdeeda:glabridin wuxuu xidhaa oo hawlgeliyaa PPAR γ, EC50 waa 6115 nm [1].Glabridin (40,80 μ M) Fidinta xadhkaha unugyada SCC-9 iyo SAS ayaa lagu hakiyay qiyaas iyo waqti ku tiirsan ka dib saacadaha 24 iyo 48 ee daaweynta [2].Glabridin (0-80 μM) Waxa kale oo ay keentaa apoptosis, taasoo horseedaysa xidhitaanka wareegga unugyada G1-hoosaadka ee SCC-9 iyo SAS unugyada [2].Glabridin (0,20,40 iyo 80 μM) Qiyaasta ku tiirsanaanta firfircoon ee Caspase-3, - 8 iyo - 9 iyo korodhay jeexjeexa PARP, oo si weyn u fosforyaal leh ERK1 / 2, JNK1 / 2 iyo P-38 MAPK ee SCC-9.Unugyada [2].

Barashada Vivo:glabridin (50 mg / kg, Po hal mar maalintii) waxay muujisay firfircooni xoog leh oo ka hortagga bararka waxayna hagaajisay isbeddelada bararka ee ay keentay dextran sodium sulfate (DSS) [3]

Tixraacyo:[1] Rebhun JF, iyo al.Aqoonsiga glabridin oo ah unug bioactive ah oo ku jira licorice (Glycyrrhiza glabra L.) soosaaray kaas oo dhaqaajiya gamma gamma-gammaan-qaadista-firfircoon ee aadanaha (PPAR γ).Fitoterapia.2015 Oct;106:55-61.
[2].Chen CT, iyo al.Glabridin wuxuu keenaa apoptosis iyo xiritaanka wareegga unugyada unugyada kansarka afka iyada oo loo marayo dariiqa calaamadaynta JNK1/2.Sunta deegaanka.2018 Jun;33 (6): 679-685.
[3]El-Ashmawy NE, iyo al.Hoos u dhigista iNOS iyo kor u qaadista cAMP waxay dhexdhexaadinaysaa saameynta anti-bararka ee glabridin ee jiirka ee leh boogaha boogaha.Inflammopharmacology.2018 Abriil;26 (2): 551-559.