Hyperoside;Hypercin Cas No. 482-36-0
Macluumaadka Dawooyinka
[magaca badeecada] hypericin
[Magaca Ingiriisiga] Hyperoside
[alias] hyperin, quercetin 3-galactoside, quercetin-3-o-galactoside
[qaabka molecular] c21h20o12
[miisaanka unugyada] 464.3763
[C sida lambarka] 482-36-0
(kala soocidda kiimikada) flavonoids
[source] Hypericum perforatum L
[Tilmaan] > 98%
[Eray bixinta badbaadada] 1. Ha neefsan boorka.2. Haddii ay dhacdo shil ama raaxo la'aan, u raadi daryeel caafimaad isla markiiba (muuji calaamadeeda haddii ay suurtagal tahay).
[waxtarka dawooyinka] Hypericin si ballaaran ayaa loo qaybiyaa.Waa badeecad dabiici ah oo muhiim ah oo leh hawlo kala duwan oo jireed, sida anti-bararka, antispasmodic, diuretic, yaraynta qufaca, hoos u dhigista cadaadiska dhiigga, hoos u dhigista kolesteroolka, isku-darka borotiinka, xanuunka maxaliga ah iyo kuwa dhexe, iyo saamaynta ilaalinta ee wadnaha iyo xididada maskaxda.
[Guryaha jireed iyo kiimikaad] crystal acicular huruud khafiif ah.Barta dhalaalka waa 227 ~ 229 ℃, iyo wareegga indhaha waa - 83 ° (C = 0.2, pyridine).Waxay si fudud ugu milmi kartaa ethanol, methanol, acetone iyo pyridine waxayna ku xasilloon tahay xaaladaha caadiga ah.Waxay la falgashaa hydrochloric acid budada magnesium si ay u soo saarto cherry cas, iyo ferric chloride waxay ka falcelisaa cagaar, α-Naphthol falcelinta waxay ahayd mid togan.
[Risk terminology] Waxyeello leh haddii la liqo.
Falka dawooyinka
1. Hypericin waxa uu leeyahay saameyn xanuun oo maxalli ah oo la taaban karo, kaas oo ka daciifsan morphine, ka xoog badan aspirin, oo aan lahayn wax ku tiirsan.Hypericin waa nooc cusub oo xanuunka maxaliga ah Isla markaana,
2. Hypericin wuxuu leeyahay saameyn wanaagsan oo ka hortag ah oo ku saabsan ischemia-ka-soo-celinta maskaxda, ischemia-ka-soo-celinta maskaxda iyo wadna xanuunka maskaxda.
3. Hypericin wuxuu leeyahay saameyn cad oo ka hortag ah: ka dib markii la geliyo kubbadda dhogorta, jiirka ayaa lagu duray 20mg / kg maalin kasta 7 maalmood, taas oo si weyn u joojisay habka bararka.
4. Waxay leedahay saamayn antitussive xoog leh.
5. Assimilation.
6. Joojinta xooggan ee aldose reductase waxay faa'iido u yeelan kartaa ka hortagga caadka macaanka.
Saamaynta difaaca ee ischemia myocardial
Hypericin wuxuu yarayn karaa heerka apoptosis ee cardiomyocytes ee ay keento hypoxia reoxygenation, joojiso sii deynta lactate dehydrogenase, wanaajiso waxqabadka myocardial superoxide dismutase (SOD) ee jiirka ee qaba dhaawaca myocardial ischemia-reperfusion, waxay yaraynaysaa soosaarka malondialdehyde (MDA), korodhka phosphokinase myocardial (CPK) ee serum, iyo in la yareeyo samaynta oxygen free xagjirka ah iyo nitric oxide free radical, Si loo ilaaliyo myocardium iyo in la yareeyo dhaawaca cardiomyocyte iyo cardiomyocyte apoptosis uu keeno ischemia-reperfusion.
Saamaynta ilaalinta maskaxda ee ischemia
Hypericin waxay si wax ku ool ah u joojin kartaa hoos u dhaca maadada formazan ee xaleefyada maskaxda ka dib dhaawaca soo noqnoqda gulukooska hypoxia, waxay kordhisaa tirada neerfayaasha nool ee kortex iyo striatum ee jeexjeexyada maskaxda ee aagga ischemic, waxayna ka dhigaysaa qaab-dhismeedka neurons-ka mid dhameystiran oo si wanaagsan loo qaybiyay.Jooji hoos u dhaca dhaqdhaqaaqa neerfaha ee ay sababtay hypoxia gulukoos-xumida dhaawaca dib-u-celinta.Jooji hoos u dhaca SOD, LDH iyo glutathione peroxidase (GSHPx).Nidaamkeedu wuxuu la xiriiri karaa xoqidda xagjirka xorta ah, joojinta qulqulka Ca2 iyo samaynta lidka ku ah peroxide.
Saamaynta ilaalinta ee beerka iyo xuubka caloosha
Hypericin waxay leedahay saameyn difaac cad oo ku saabsan unugyada beerka iyo xuubka caloosha.Nidaamkeedu wuxuu la xiriiraa saameynta antioxidant, kor u qaadida soo celinta heerka N0 ee caadiga ah iyo kordhinta dhaqdhaqaaqa SOD.
Saamaynta xanuunka xanuunka 'antispasmodic'
Daraasadu waxay ogaatay in saameynta xanuunka hypericin ay soo saarto iyada oo la yareeyo Ca 2 ee dareemaha xanuunka.Isla mar ahaantaana, hypericin waxay joojin kartaa qulqulka Ca 2 ee ay keento potassium sare, taas oo muujinaysa in hypericin uu sidoo kale xannibo kanaalka Ca ee unugyada dareemayaasha.Waxa kale oo la soo jeediyay in hypericin ay noqon karto xannibaadaha Ca 2 kanaalka.Kormeerka bukaan-socodka ayaa muujinaya in cirbadeynta hypericin ay la mid tahay atropine ee daaweynta dysmenorrhea aasaasiga ah.Marka laga reebo dhowr waxyeelooyin oo hurdo ah, ma laha falcelin xun oo caadi ah sida tachycardia, mydriasis iyo dareenka gubasho.Waa antispasmodic ku habboon iyo xanuunka.
Saamaynta Hypolipidemic
Hypericin wuxuu si weyn u dhimi karaa serum TC wuxuuna kordhin karaa saamiga HDL / TC ee jiirarka dufanka badan, taasoo muujinaysa in hypericin ay yarayn karto kolestaroolka, nidaamin karto dufanka dhiigga, iyo hagaajinta dhaqdhaqaaqa HDL iyo serum SOD ee jiirarka.Saamayntani waxay si weyn u yareeyn kartaa waxyeelada xagjirka xorta ah ee superoxide ilaa endothelium vascular ee hyperlipidemia, waxayna u fiican tahay kala-goynta iyo dheef-shiid kiimikaadka lipid peroxide si loo ilaaliyo endothelium vascular.
Kor u qaad shaqada difaaca
Hypericin ee qiyaasta 300 mg / kg iyo 150 mg / kg in vivo waxay si weyn u joojin kartaa tusaha thymus, bararka beeryarada T iyo B lymphocytes iyo phagocytosis ee macrophages peritoneal;59 mg / kg, waxay si weyn u xoojisay bararka beeryarada T iyo B lymphocytes iyo phagocytosis ee macrophages peritoneal.Hypericin ee qiyaasta 50 ~ 6.25 ml in vitro waxay si weyn kor ugu qaadi kartaa faafinta beeryarada T iyo B lymphocytes waxayna kor u qaadi kartaa awoodda T lymphocytes si ay u soo saarto IL-2;Hypericin at 6.25 g / ml waxay si weyn u kordhisay awoodda mouse peritoneal macrophages si ay u phagocytize neutrophils, oo u dhexeeya 12.5 ilaa 3.12 μG / ml si weyn u kordhisay awoodda macrophages mouse peritoneal macrophages si ay u sii daayo No.
Saamaynta niyad-jabka
Dhaqdhaqaaqa hypothalamic pituitary adrenal (HPA) waa isbeddel bayooloji caadi ah oo ku dhaca bukaanada qaba niyad-jabka daran, kaas oo lagu garto dheecaan xad-dhaaf ah oo hormoonka adrenocorticotropic hormone (ACTH) iyo cortisol.Hypericin wuxuu nidaamin karaa shaqada dhidibka HPA wuxuuna hoos u dhigi karaa heerarka ACTH iyo corticosterone, si uu u ciyaaro doorka ka hortagga niyad-jabka.
Daawo Dhamaystiran
Ciwujia kaabsal
Kaabsoosha Acanthopanax senticosus waa diyaargarow leh jirrid Acanthopanax senticosus iyo caleen soosaaray sida walxo ceeriin ah.Qaybta ugu muhiimsan waa flavonoids, kaas oo hypericin uu yahay qaybta firfircoon ee caleemaha Acanthopanax senticosus.
Tilmaamaha ugu muhiimsan: kor u qaadida wareegga dhiigga iyo ka saarista fadhiidnimada dhiigga.Waxa loo isticmaalaa arthralgia laabta iyo cudurrada wadnaha ee ay keento fadhiidnimada dhiigga.Calaamadaha waxaa ka mid ah xabad xanuun, laabta oo adkaata, garaaca wadnaha, dhiig karka, iwm. waxaa iska leh yaraanta beeryarada iyo kelyaha iyo joogsiga dhiigga iyo Yin.
Xinan kaabsal
Waa diyaargarow laga sameeyay caleen hawthorn ah, oo qani ku ah flavonoids, kaas oo hypericin uu ka mid yahay qaybaha ugu muhiimsan.
Tilmaamaha ugu muhiimsan: balaadhiso habka wadnaha iyo xididada, wanaaji sahayda dhiiga myocardial waxayna yareeyaan dufanka dhiiga.Waxaa loo isticmaalaa in lagu daaweeyo cudurrada wadnaha, angina pectoris, laabta oo adkaata, garaaca wadnaha, hypertension, iwm.
Kiniinka Qiyue Jiangzhi
Kiniiniga Qiyue Jiangzhi waa dawo dhaqameed shiineys ah oo saafi ah oo hoos u dhigta daawada lipid-hoos u dhigista iyada oo la soo saarayo qaybaha waxtarka leh ee dawooyinka dhaqameed ee Shiinaha sida hawthorn (enucleated) iyo Astragalus membranaceus.Mid ka mid ah qaybaha ugu muhiimsan ee waxtarka leh ee hawthorn waa flavonoids, kaas oo ka kooban hypericin uu sarreeyo.
Tilmaamaha ugu muhiimsan: yaraynta dufanka dhiigga oo jilcisa xididdada dhiigga.Waxaa loo isticmaalaa si kor loogu qaado wareegga dhiigga ee halbowlayaasha iyo la dagaallanka arrhythmia iyo hyperlipidemia.
Kiniinka Xinxuening
Kiniiniga Xinxuening waa diyaarin ka kooban dawo dhaqameed Shiinees ah sida hawthorn iyo pueraria.Hawthorn waa daawada rasmiga ah ee xisbigayaga.Waxay ka kooban tahay ursolic acid, Vitexin rhamnoside, hypericin, citric acid, iwm, kuwaas oo hypericin ay tahay qaybta ugu muhiimsan.
Tilmaamaha ugu muhiimsan: kor u qaadida wareegga dhiigga iyo ka saarista fadhiidnimada dhiigga, daadinta dammaanadda iyo yaraynta xanuunka.Waxaa loo isticmaalaa arthralgia laabta iyo vertigo oo ay sababto istaagga dhiigga wadnaha iyo xuubka maskaxda, iyo sidoo kale cudurada wadnaha, dhiig karka, angina pectoris iyo hyperlipidemia.
Kaabsulka Yukexin
Kaabsulka Yukexin waa dawo dhaqameed Shiinees ah oo laga soo saaray warqad qadiimi ah, kaas oo ka kooban Hypericum perforatum, kernel duurjoogta ah, jilif Albizzia, Gladiolus iyo dawooyinka dhaqanka Shiinaha.Waxay inta badan ka kooban tahay hypericin, quercetin, quercetin, chlorogenic acid, caffeic acid, yimaning, hypericin iyo qaybo kale.
Tilmaamaha ugu muhiimsan: niyad-jabka maskaxeed ee uu keeno nasasho la'aanta beerka qi iyo niyad xumo.
