Neohesperidin
Codsiga Synephrine Hydrochloride
Neohesperidin waa nooc flavonoid ah oo si weyn ugu dhex jira dhirta Cucurbitaceae waxayna leedahay saameyn antioxidant iyo anti-bararka./h2>
Magaca Neohesperidin
Magaca Ingiriisiga: neohesperidin
Magaca Shiinaha: neohesperidin |neohesperidin
Bioactivity ee Neohesperidin
Sharaxaad: neohesperidin waa maaddo flavonoid ah oo laga helo Cucurbitaceae, kaas oo leh saameyn antioxidant iyo anti-bararka.
Qaybaha la xidhiidha: Jidka ishaarada > > kale > > kale
goobta cilmi-baarista > > caabuq / difaac
Waxyaabaha dabiiciga ah >> flavonoids
Barashada Vitro dhexdeeda:
Hesperidin cusub wuxuu keenaa apoptosis kansarka naasaha aadanaha ee unugyada MDA-MB-231.Qiimaha IC50 ee neohesperidin ee saacadaha 24 iyo 48 waxay ahaayeen 47.4 ± 2.6, siday u kala horreeyaan μ M iyo 32.5 ± 1.8 μM la habeeyey [1].Neohesperidin wuxuu muujiyay waxqabadka antioxidant ee DPPH tijaabada xoqida xagjirka ah (IC50 = 22.31 μ g / ml) [2].
Daraasadda Vivo: neohesperidin (50mg / kg) ayaa si weyn u joojiyay 55.0% HCl / ethanol dhaawaca caloosha.Jiirka pylorus ligated, neohesperidin (50 mg / kg) ayaa si weyn hoos ugu dhigay dheecaanka gastric iyo wax soo saarka acid gastric iyo korodhka pH [1].Daaweynta Neohesperidin waxay si weyn hoos ugu dhigtay gulukoosta dhiigga ee soonka, gulukooska dhiigga iyo borotiinka serum glycosylated (GSP) ee jiirarka.Waxay si weyn u kordhisay dulqaadka gulukooska afka iyo dareenka insulin, waxayna hoos u dhigtay caabbinta insulin ee jiirarka macaanka.Neohesperidin waxay si weyn hoos ugu dhigtay serum triglycerides, wadarta kolestaroolka, heerarka leptin iyo index beerka ee jiirarka [3].
Tijaabada Xayawaanka: Jiirarka: Dhammaan jiirarka waxay soomeen 6 saacadood ka hor baaritaanka, ka dibna waxaa lagu quudiyay biyo ama neohesperidin quudin qasab ah.Marka loo eego OGTT iyo ITT, jiirarka waxaa lagu duray intraperitoneal 2G/kg oo gulukoos BW ah ama 1iu/kg insulin BW, siday u kala horreeyaan.Muundooyinka dhiigga ayaa laga soo ururiyey xididka caudal si loo cabbiro heerarka gulukoosta dhiigga ee asalka ah (0 daqiiqo) ka hor intaan la duro gulukoosta ama insulinta.Heerarka gulukooska dhiigga ee dheeraadka ah ayaa lagu qiyaasay 30, 60, 90 iyo 120 daqiiqo [3].
Tixraac:[1].Lee JH, iyo al.Saamaynta ilaalinta ee neohesperidin iyo poncirin oo laga soocay midhaha Poncirus trifoliata ee cudurada caloosha ee suurtogalka ah.Phytother Res.2009 Dec;23 (12):1748-53.
[2].Xu F, iyo al.Neohesperidin wuxuu ku keenaa apoptosis-ka gacanta ee naaska adenocarcinoma ee unugyada MDA-MB-231 iyada oo la dhaqaajinayo dariiqa calaamadaynta Bcl-2/Bax.Nat Prod Commun.2012 Nov; 7 (11): 1475-8.
[3]Jia S, iyo al.Saamaynta hypoglycemic iyo hypolipidemic ee neohesperidin oo laga soo qaatay Citrus aurantium L. ee jiirka KK-A(y) ee macaanka.Shaqada Cuntada2015 Mar; 6 (3): 878-86.
Astaamaha Fiisiko Kiimiko ee Neohesperidin
Cufnaanta: 1.7 ± 0.1 g / cm3
Barta karkarinta: 933.7 ± 65.0 ° C at 760 mmHg
Meesha dhalaalaysa: 239-243 º C
Qaacidada unugyada: C28H34O15
Miisaanka Molecular: 610.561
Barta Tooshka ah: 306.7 ± 27.8 ° C
Tirada saxda ah: 610.189758
PSA:234.29000
LogP:2.44
Muuqashada: 0.0 ± 0.3 mmHg at 25 ° C
Cadaadiska Uumiga: 0.0 ± 0.3 mmHg at 25 ° C
Tusmada dib-u-celinta: 1.695
Xaaladaha Kaydinta: 2-8 ° C
Macluumaadka Badbaadada Hesperidin ee cusub
Qalabka ilaalinta shakhsi ahaaneed: indho;Gacan-gashiyada;nooca N95 (US);nooca P1 (EN143) filtarka neefsiga
Bayaanka Badbaadada (Yurub): s22-s24 / 25
Xeerka gaadiidka ee alaabta khatarta ah: noh ee dhammaan noocyada gaadiidka
Wgk Germany: 3
RTECS No.: dj2981400
Suugaanta Neohesperidin
Falanqaynta dheef-shiid kiimikaadka iyo qoraalka isbarbardhigga ee diploid labanlaaban iyo rootstock liinta diploid (C. junos cv. Ziyang xiangcheng) waxay soo jeedinaysaa qiimaha suurtagalka ah ee hagaajinta iska caabbinta walbahaarka.
BMC Plant Biol.15 , 89, (2015)
Polyploidy ayaa inta badan loo tixgeliyey inay siiso dhirta si ka wanaagsan ula qabsiga walaaca deegaanka.Xididdada citrus ee Tetraploid ayaa la filayaa inay yeeshaan dulqaad ka xoog badan marka loo eego diploid.Waxbadan...
Ougan (Citrus reticulata cv. Suavissima) soosaarida flavedo waxay xakamaysaa dhaqdhaqaaqa kansarka iyada oo faragalinaysa kala-guurka epithelial-to-mesenchymal ee unugyada SKOV3.
GarkaMed.10 , 14, (2015)
Ougan (Citrus reticulata cv. Suavissima) laga soosaaray flavedo (OFE) waxay soo bandhigtay saamaynta lidka ku ah buro ee iman karta oo leh habab hoose oo aan caddayn.Daraasadan waxay ujeedadeedu tahay in lagu qiimeeyo firfircoonida ka hortagga metastatic ee suurtagalka ah ...
Hesperidin, nobiletin, iyo tangeretin ayaa si wadajir ah mas'uul uga ah awoodda anti-neuroinflammatory ee diirka tangerine-ka (Citri reticulatae pericarpium).
Cuntada Chem.Sun.71, 176-82, (2014)
Joojinta firfircoonida microglial-dhexdhexaadinta neuroinflammation waxay noqotay bartilmaameed lagu qanco oo loogu talagalay horumarinta cuntooyinka shaqada si loo daaweeyo cudurrada neurodegenerative.Diirka Tangerine (Citri reticulata...
Magaca Ingiriisiga ee Neohesperidin
HESPERETIN-7-NEOHESPERIDOSIDE
Hesperetin7-neohesperidoside
4H-1-Benzopyran-4-kow, 7-[[2-O- (6-deoxy-α-L-mannopyranosyl) -β-D-glucopyranosyl] -2,3-dihydro-5-hydroxy-2 -(3-hydroxy-4-methoxyphenyl)-, (2S)
(2S)-5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 2-O-(6-deoxy-α-L- mannopyranosyl) -β-D-glucopyranoside
Hesperetin 7-O-neohesperoside
Neohesperdin
Neohesperdin
MFCD00017357
Hesperetin-7-O-neohesperidoside
EINECS 236-216-9
(S)-4'-Methoxy-3',5,7-trihydroxyflavanone-7-[2-O- (α-L-rhamnopyranosyl)-β-D-glucopyranoside]
4H-1-Benzopyran-4-hal, 2,3-dihydro-7-(2-O- (6-deoxy-a-L-mannopyranosyl)-β-D-glucopyranosyl) oxy) -5-hydroxy-2 -(3-hydroxy-4-methoxyphenyl)-, (S)
Hesperetin 7-O-neohesperidoside
