Ophiopogonin D Cas No.945619-74-9
Ophiopogon Saponin D Magaca
Magaca Ingiriisiga:(1β,3β,25R) -3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)] -6-deoxy-β-D-galactopyranoside
Dhaqdhaqaaqa noole ee Ophiopogon Japonicus Saponin D
Sharaxaad:Ophiopogon D waa naadirka dabiiciga ah ee C29 steroidal glycoside oo ka go'an tuber of Ophiopogon japonicus.Ophiopogonin D waa CYP2J3 inducer kaas oo kordhiya CYP2J2 / eets iyo PPAR ee unugyada xuddunta xudunta ee bini'aadamka (HUVECs) α Muujinta Ang II waxay si weyn u joojisay Ang II oo u horseeday NF-κ B nukliyeerka NF-κ B, I κ B α Nidaamka Down2 + intracellular xad-dhaaf ah iyo firfircoonida cytokines proinflammatory.Ophiopogonin D waxa loo isticmaalay in lagu daweeyo caabuqa iyo cudurrada wadnaha iyo xididdada kumanaan sano.
Qaybaha khuseeya
Jidka calaamadaynta > > Gaadiidka transmembrane > > kanaalka calcium
Goobta cilmi-baarista > > Cudurrada wadnaha iyo xididdada
Dariiqa calaamadaynta > > wareegga unugyada / dhaawaca DNA> PPAR
Goobta cilmi-baarista > > caabuq / difaac
Bartilmaameedka
PPARA
NF-κB
Ca2+
Dukumentiyada Tixraaca:[1]Wang L, iyo al.Homo-aro-cholestane, furostane iyo spirostane saponins ee digriiga Ophiopogonjaponicus.Phytochemistry.2017 Abril;136:125-132.
[2].Huang X, iyo al.Ophiopogonin D iyo EETs waxay hagaajiyaan jawaabaha caabuqa ee uu keenay Ang II iyada oo la hawlgelinayo PPARA gudaha HUVECs.Biochem Biophys Res Commun.2017 Agoosto 19;490(2):123-133.
Magaca Ingiriisiga ee Ophiopogon saponin D
(1β,3β,25R) -3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)] -6-deoxy-β-D-galactopyranoside β-D-Galactopyranoside, (1β,3β,25R) -3-hydroxyspirost-5-en-1-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O-[β-D-xylopyranosyl-(1->3)]-6-deoxy-
(2S,3R,4R,5R,6S)-2-((2R,3R,4S,5S,6R)-5-hydroxy-2-(((4R,5'R,6R,6aR,6bS,8aS) ,8bR,9S,10R,11aS,12aS,12bS)-4-hydroxy-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a, 6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2 '-pyran] -6-yl) oxy) -6-methyl-4-((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydro- 2H-pyran-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol
Ophiopogonin D
Deacetylophiopogonin C
