Salvianolic acid C
Ujeedo
Salvianolic acid C waa xakameyn aan tartan lahayn oo ah cytochrome p4502c8 (cyp2c8) iyo xakameyn isku dhafan ee cytochrome P4502J2 (CYP2J2) oo leh dhexdhexaad dhexdhexaad ah.Qiimaheeda Ki ee cyp2c8 iyo CYP2J2 waa 4.82 siday u kala horreeyaan μM iyo 5.75 μM
Magaca Ingiriisiga
(2R)-3-(3,4-Dihydroxyphenyl)-2-({(2E)-3-[2-(3,4-dihydroxyphenyl)- 7-hydroxy-1-benzofuran-4-yl]-2- propenoyl}oxy) propanoic acid
Af-Ingiriisi Magaciisa
(2R)-3-(3,4-Dihydroxyphenyl)-2-({(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl] prop-2 -enoyl}oxy) propanoic acid
(2R)-3-(3,4-Dihydroxyphenyl)-2-({(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]-2- propenoyl}oxy) propanoic acid
Benzenepropanoic acid, α-[[(2E) -3-[2- (3,4-dihydroxyphenyl)-7-hydroxy-4-benzofuranyl]-1-oxo-2-propen-1-yl] oxy]-3, 4-dihydroxy-, (αR)-
Salvianolic acid C
Sifooyinka Kiimikaad ee Salvianolic Acid C
Cufnaanta: 1.6 ± 0.1 g / cm3
Barta karkarinta: 844.2 ± 65.0 ° C at 760 mmHg
Qaacidada molecular: C26H20O10
Miisaanka Molecular: 492.431
Barta iftiimaya: 464.4 ± 34.3 ° C
Tirada saxda ah: 492.105652
PSA: 177.89000
LogP: 3.12
Cadaadiska Uumiga: 0.0 ± 3.3 mmHg at 25 ° C
Tusmada dib-u-celinta: 1.752
Dhaqdhaqaaqa noole ee Salvianolic Acid C
Sharaxaad:
Salvianolic acid C waa xakameyn aan tartan lahayn oo ah cytochrome p4502c8 (cyp2c8) iyo xakameyn isku dhafan ee cytochrome P4502J2 (CYP2J2) oo leh dhexdhexaad dhexdhexaad ah.Qiimaheeda Ki ee cyp2c8 iyo CYP2J2 waa 4.82 siday u kala horreeyaan μM iyo 5.75 μM.
Qaybaha khuseeya:
Dariiqa calaamadaynta > > dheef-shiid kiimikaadka enzyme / protease > > cytochrome P450
Goobta cilmi-baarista > > kansarka
Alaabta Dabiiciga ah > > kuwa kale
Bartilmaameedka:
CYP2C8: 4.82 μM (Ki)
CYP2J2: 5.75 μM (Ki)
Barashada Vitro dhexdeeda:
Salvianolic acid C waa xakameyn isku dhafan oo dhexdhexaad ah oo aan tartan ahayn cyp2c8 inhibitor iyo CYP2J2.KIS ee cyp2c8 iyo CYP2J2 waa 4.82 iyo 5.75 siday u kala horreeyaan μM[1].Salvianolic acid C ayaa si weyn u yareeyay muujinta iNOS.Salvianolic acid C waxay joojisaa LPS TNF-a, IL-1 β, IL-6 iyo IL-10 ayaa la soo saaray.Salvianolic acid C waxay joojisaa dhaqdhaqaaqa LPS ee NF-κ B.Salvianolic acid C ayaa sidoo kale kordhisay muujinta Nrf2 iyo HO-1 ee BV2 microglia [2].
Barashada Vivo:
Daawaynta Salvianolic acid C (20mg/kg/kg) ayaa si weyn hoos ugu dhigtay daahitaanka baxsashada.Intaa waxaa dheer, daaweynta SALC (10 iyo 20 mg / kg) waxay si weyn u kordhisay tirada isgoysyada madal marka la barbar dhigo kooxda model LPS.Marka la barbardhigo kooxda moodeelka, maamulka nidaamka salvianolic acid C hoos u habaysan maskaxda TNF-a, IL-1 β Iyo IL-6 heerarka.Heerarka iNOS iyo COX-2 ee kiliyaha maskaxda iyo hippocampus ee jiirka ayaa ka sarreeya kuwa ku jira kooxda kantaroolka, halka daaweynta salvianolic acid C ay si weyn hoos ugu dhigtay kiliyaha iyo hippocampus.Salvianolic acid C (5, 10 iyo 20 mg / kg) daawaynta waxay kordhisay p-ampk, Nrf2, HO-1 iyo heerarka NQO1 ee kiliyaha maskaxda ee jiirka iyo hippocampus qaab ku tiirsan qiyaasta [2].
Tixraac:
[1]Xu MJ, iyo al.Saamaynta xannibaadda ee qaybaha Danshen ee CYP2C8 iyo CYP2J2.Chem Biol Interact.2018 Juun 1;289:15-22.
[2].Heesta J, iyo al.Dhaqdhaqaaqa Nrf2 ee calaamadinta salvianolic acid C waxay hoos u dhigtaa NF κ B dhexdhexaadinta jawaab-celinta bararka labadaba gudaha vivo iyo in vitro.Int Immunopharmacol.2018 Oct;63:299-310.
