3-Hydroxy-9,10-dimethoxyptercarpan,Methylnissolin
Tšebeliso ea Methylnissolin
Methylnisolin (astrapterocarpan) e arohane le Astragalus membranaceus 'me e ka thibela ho ata ha sele e bakoang ke platelet-derived growth factor (PDGF) - BB, e nang le IC50 ea 10 μ M. Methylnisolin e thibela phosphorylation ea extracellular signal regulated kinase 1 / 2 2) mitogen activated protein (mapa) kinase e susumelitsoeng ke PDGF-BB.Methylnisolin e thibela PDGF-BB e bakang ho ata ha lisele tsa mesifa ea mesifa e boreleli ka ho thibela ERK1 / 2 MAP kinase cascade.
Lebitso la Methylnissolin
Lebitso la Senyesemane:
(-) -6aR,11aR-dihydro-3-hydroxy-9,10-dimethoxy-6H-benzofuro[3,2-c][1]-benzopyran
Litlaleho tsa Sechaena: 3-hydroxy-9,10-dimethoxy red sandalwood |Astragalus e khubelu
sandalwood |(6aR, 11ar) - 3-hydroxy-9,10-dimethoxy red sandalwood
Ts'ebetso ea Biological ea Methylnissolin
Tlhaloso: methylnisolin (astrapterocarpan) e arohane le Astragalus membranaceus
'me e ka thibela ho ata ha lisele tse bakoang ke platelet-derived growth factor (PDGF) - BB.
IC50 ke 10 μ M. Methylnisolin e thibela phosphorylation ea letšoao la extracellular
regulated kinase 1 / 2 (eric1 / 2) mitogen activated protein (mapa) kinase e susumetsoang ke
PDGF-BB.Methylnisolin e thibela PDGF-BB e bakang ho ata ha vascular smooth
lisele tsa mesifa ka ho thibela ERK1 / 2 MAP kinase cascade.
Likarolo tse amanang: sebaka sa lipatlisiso > > lefu la pelo
tsela ea pontšo > > protheine tyrosine kinase > > PDGFR
tsela ea lets'oao>> MAPK / tsela ea lets'oao la ERK> > ERK
tsela ya matshwao > > stem cells le Wnt pathway > > ERK
Tlokotsi:PDGFR:10 μM (IC50)
ERK1
ERK2
Tšupiso:[1].Ohkawara S, le ba bang.Astrapterocarpan e arohaneng le Astragalus membranaceus e thibela ho ata ha lisele tsa mesifa ea mesifa.Eur J Pharmacol.2005 Nov 21;525(1-3):41-7.
Lintho tsa physicochemical tsa Methylnissolin
Boima: 1.3 ± 0.1 g / cm3
Ntho e Belang: 428.9 ± 45.0 ° C ho 760 mmHg
Foromo ea molek'hule: c17h16o5
Boima ba 'mele: 300.306
Sebaka sa Flash: 213.2 ± 28.7 ° C
'Misa o Nepahetseng: 300.099762
PSA: 57.15000
Lethathamo: 2.45
Khatello ea Mouoane: 0.0 ± 1.1 mmHg ho 25 ° C
Index ea Refractive: 1.612
Jiangsu Yongjian Pharmaceutical Technology Co., Ltd.
Jiangsu Yongjian Pharmaceutical Technology Co., Ltd., e thehiloeng ka Hlakubele 2012, ke khoebo ea theknoloji e phahameng e kopanyang R & D, tlhahiso le thekiso.Haholo-holo e kopanela tlhahisong, ho itloaetsa le nts'etsopele ea ts'ebetso ea tlhahiso ea likarolo tse sebetsang tsa lihlahisoa tsa tlhaho, lisebelisoa tsa setso tsa meriana ea Chaena le litšila tsa lithethefatsi.Khamphani e sebakeng sa China Pharmaceutical City, Taizhou City, Profinseng ea Jiangsu, ho kenyeletsoa setsi sa tlhahiso ea lisekoere-mithara tse 5000 le setsi sa R&D sa 2000 metres.E sebeletsa haholo litsi tse kholo tsa lipatlisiso tsa mahlale, liunivesithi le likhoebo tsa tlhahiso ea likotoana tsa li-decoction naheng ka bophara.
Ho fihlela joale, re ntlafalitse mefuta e fetang 1500 ea li-reagents tsa tlhaho tsa tlhaho, 'me re bapisa le ho lekanya mefuta e fetang 300 ea lisebelisoa tsa litšupiso, tse ka kopanang ka botlalo le litlhoko tsa tlhahlobo ea letsatsi le letsatsi tsa litsi tse kholo tsa lipatlisiso tsa mahlale, lilaboratori tsa univesithi le likhoebo tsa tlhahiso ea decoction.
E itšetlehile ka molao-motheo oa tumelo e ntle, k'hamphani e tšepa ho sebelisana le bareki ba rona ka tieo.Sepheo sa rona ke ho sebeletsa ntlafatso ea meriana ea setso ea Chaena.
Advantageous Business Scope Of The company
1. R & D, tlhahiso le thekiso ea lisebelisoa tsa litšupiso tsa lik'hemik'hale tsa meriana ea setso ea Chaena;
2. Metsoako e ikhethileng ea meriana ea setso ea China monomer ho latela litšobotsi tsa bareki
3. Patlisiso ka maemo a boleng le nts'etsopele ea ts'ebetso ea moriana oa setso oa Machaena (semela).
4. Tšebelisano ea thekenoloji, phetisetso le lipatlisiso le nts'etsopele ea lithethefatsi tse ncha.
