Lihlahisoa

Tlhaloso:monoammonium glycyrrhizinate hydrate e na le mesebetsi ea pharmacological joalo ka anti-inflammatory, anti allergic, anti gastric ulcer le anti hepatitis.

Lihlopha tse amanang:
tsela ya letshwao > > tse ding > > tse ding
Sebaka sa lipatlisiso>> ho ruruha / ho itšireletsa mafung

Thutong ea Vivo:Keketseho ea boima ba 'mele ea matšoafo w / D e fokotsehile haholo ka ho tsamaisoa ha litekanyetso tse phahameng le tse mahareng tsa mag (10 le 30 mg / kg).Ho phekola ka mag (10 le 30 mg / kg) ka katleho ho fokolitse TNF- α Le IL-1 β Generation ea.Mag (10,30 mg / kg) e fokolitse NF haholo ha e bapisoa le LPS- κ Bp65 polelo ea protheine.Ka lehlakoreng le leng, LPS e fokotsehile haholo ha ke bapisoa le sehlopha sa taolo κ B- α Polelo ea protheine, ha mag (10 le 30 mg / kg) e eketsehile haholo I κ B- α Expression [1].Ha ho bapisoa le lihlopha tsa RIF le INH, phekolo ea meriana e tlaase le e phahameng ea MAG e fokotsehile haholo maemong a ast, alt, TBIL le TBA matsatsing a 14 le a 21, e bontšang phello ea tšireletso ea MAG ho RIF - le INH -.Hlahisa kotsi ea sebete.Sehlopha sa phekolo ea MAG se ile sa eketsa boemo ba sebete sa GSH matsatsing a 7, 14 le 21, 'me sa fokotsa haholo boemo ba MDA matsatsing a 14 le 21 ka likhoto tse tšoaroang ke RIF le INH, tse bontšang phello ea tšireletso ea MAG ho RIF - le.INH e bakile kotsi ea sebete [2].

Liteko tsa Liphoofolo:litoeba [1] thutong ena, litoeba tsa BALB / c (tse tona, libeke tse 6-8, 20-25g) li sebelisitsoe.Litoeba li ne li arotsoe ka lihlopha tsa 5: sehlopha sa taolo, sehlopha sa LPS le LPS + monoammonium glycyrrhizinate (Mag: 3,10 le 30mg / kg).Sehlopha ka seng se ne se e-na le litoeba tse 8.Litoeba li ile tsa hlajoa ka ente ea intraperitoneal ea pentobarbital sodium (50 mg / kg).Litoeba li ne li entoa ka intraperitoneally ka mag (3, 10 le 30 mg / kg) pele li baka kotsi e mpe ea matšoafo.Kamora hora e le 'ngoe, LPS (5 mg / kg) e ile ea kenngoa intracheal ho baka kotsi e mpe ea matšoafo.Litoeba tse tloaelehileng li ile tsa fuoa PBS [1].Likhoto [2] li sebelisitse likhoto tse tona tsa Wistar (180-220g).Litoeba li ne li arotsoe ka lihlopha tsa 4: sehlopha sa taolo, sehlopha sa RIF le INH, sehlopha sa MAG sa tekanyo e tlaase le sehlopha sa MAG se phahameng, se nang le likhoto tsa 15 sehlopheng ka seng.Likhoto tsa lihlopha tsa RIF le INH li ile tsa fuoa RIF (60mg / kg) le INH (60mg / kg) ka gavage hang ka letsatsi;Litoeba tsa sehlopha sa MAG li ne li etsoa pele ka MAG ka tekanyo ea 45 kapa 90 mg / kg, le RIF (60 mg / kg) le INH (60 mg / kg) li ile tsa fuoa lihora tsa 3 ka mor'a tsamaiso ea MAG;Likhoto tsa sehlopha sa taolo li ne li phekoloa ka saline e tloaelehileng.E le ho hlahloba phello e matla ea lithethefatsi, likhoto sehlopheng ka seng li ile tsa bolaoa 7, 14 le matsatsi a 21 ka mor'a tsamaiso [2].

Referense:1].Huang X, et al.Liphello Tse Khahlanong le Ho ruruha tsa Monoammonium Glycyrrhizinate ho Lipopolysaccharide-Induced Acute Lung Kotsi ho Litoeba ka ho Laola Nuclear Factor-Kappa B Signaling Pathway.Evid Based Complement Alternat Med.2015;2015:272474.
[2].Zhou L, le ba bang.Monoammonium glycyrrhizinate e sireletsa rifampicin- le isoniazid-induced hepatotoxicity ka ho laola polelo ea sepalangoang Mrp2, Ntcp, le Oatp1a4 sebeteng.Pharm Biol.2016;54(6):931-7.