Astragaloside IV CAS No. 84687-43-4
Kenyelletso e Khutšoanyane
Lebitso la Senyesemane:Astragaloside IV;beta-D-Glucopyranoside, (3beta, 6alpha,16beta,24R) -20,24-epoxy-16,25-dihydroxy-3-(beta-D-xylopyranosyloxy) -9,19-cyclolanostan-6-yl;(3beta,6alpha,9beta,16beta,20R,24S)-16,25-dihydroxy-3-(beta-D-xylopyranosyloxy)-20,24-epoxy-9,19-cyclolanostan-6-yl beta-D-threo - hexopyranoside
Foromo ea molek'hule:C41H68O14
Lebitso la lik'hemik'hale:17- [5-(1-Hydroxyl-1-methyl-ethyl)- 2methyl-tetrahydro- furan-2-yl]-4,4,13,14-tetramethyl-tetradecahydro-cyclopropa[9,10]cyclopenta[a] phenanthren-16-ol-3-β-D-aracopyranosyl-6-β-D-glucoside
Mp:200 ~ 204 ℃
[α]D:-56.6 (c,0.13 ho DMF)
UV:λmax203 nm
bohloeki:98%
Mohloli:legume Astragalus membranaceus, Astragalus pubescens.
Foromo ea sebopeho sa lik'hemik'hale tsa astragaloside IV
Thepa ea Physicochemical
[ponahalo]:phofo e tšoeu ea kristale
[bohloeki]:ka holimo ho 98%, mokhoa oa ho lemoha: HPLC
[mohloli oa semela]:metso ea Astragalus Alexandrinus Boiss, Astragalus dissectus, Astragalus membranaceus (Fisch.) Bungede motso, Astragalus sieversianus Pall Root ea Astragalus spinosus Vahl, karolo ea moeeng ea Astragalus spinosus Vahl.
[thepa ea sehlahisoa]:Motsoako oa Astragalus membranaceus ke phofo e sootho e mosehla.
[maikemisetso a litaba]:etsa qeto ka HPLC (Sehlomathiso VI D, Volume I, Chinese Pharmacopoeia, Khatiso ea 2010).
Chromatographic situations and system applicability test} octadecyl silane bonded silica gel e sebelisoa e le filler, acetonitrile water (32:68) e sebelisoa e le mobile phase, 'me evaporative light scattering detector e sebelisoa ho lemoha.Palo ea lipoleiti tsa theoretical ha e na ho ba ka tlase ho 4000 ho latela tlhoro ea astragaloside IV.
Ho lokisoa ha tharollo ea litšupiso, nka palo e loketseng ea tšupiso ea astragaloside IV, e lekanye ka nepo, 'me u kenye methanol ho lokisa tharollo e nang le 0.5mg ka 1ml.
Ho lokisa tharollo ea tlhahlobo:nka hoo e ka bang 4G ea phofo sehlahisoa sena, se lekanya ka mokhoa o nepahetseng, se kenye ho Soxhlet extractor, eketsa 40ml ea methanol, e inetse bosiu bo le bong, eketsa tekanyo e loketseng ea methanol, mocheso le reflux bakeng sa lihora tse 4, khutlisetsa solvent ho tsoa le ho tsepamisa mohopolo. ho omisa, eketsa 10ml ea metsi ho qhala masala, sisinya le ho e ntša ka saturated n-butanol ka makhetlo a 4, 40ml nako le nako, kopanya tharollo ea n-butanol, 'me ue hlatsoe ka botlalo ka tharollo ea ammonia bakeng sa makhetlo a 2, 40ml e' ngoe le e 'ngoe. Nako, lahla tharollo ea ammonia, mouoane tharollo ea n-butanol, eketsa metsi a 5ml ho qhala masala, 'me u a pholile, Ka D101 macroporous adsorption resin column (bophara bo ka hare: 37.5px, bophahamo ba kholomo: 300px), elute ka 50ml ea metsi , lahla tharollo ea metsi, ethanol e nang le 30ml ea 40% ethanol, lahla ntho e sa tloaelehang, elute ka 80ml ea 70% ea ethanol, bokella ntho e ka ntle, e mouwane e omelle, qhala masalla ka methanol, e fetisetsa ho 5ml volumetric flask, eketsa. methanol ho ea sekaleng, sisinya hantle, lejoale fumana.
Mokhoa oa ho khetha:ka nepo monya 10% ea tharollo ea litšupiso ka ho latellana μ l, 20 μ l.Tharollo ea teko 20 mong le e mong μ l.E kenye ka har'a mokelikeli oa chromatograph, e lekanye, 'me u e bale ka palo ea logarithm ea mokhoa oa kantle oa lintlha tse peli.
E baloang e le sehlahisoa se omeletseng, litaba tsa astragaloside IV (c41h68o14) ha li na ho ba ka tlase ho 0.040%
Ketso ea Pharmacological
Likarolo tse kholo tse sebetsang tsa Astragalus ke polysaccharides le astragaloside.Astragaloside e arotsoe ka astragaloside I, astragaloside II le astragaloside IV.Har'a bona, astragaloside IV, astragaloside IV, e na le ts'ebetso e ntle ka ho fetisisa ea tlhaho.Astragaloside IV ha e na phello ea Astragalus polysaccharides feela, empa e boetse e na le litlamorao tse ke keng tsa bapisoa tsa Astragalus polysaccharides.Matla a eona a sebetsang a feta habeli a astragalus polysaccharides a tloaelehileng, 'me phello ea eona ea antiviral ke makhetlo a 30 a Astragalus polysaccharides.Ka lebaka la litaba tsa eona tse tlase le phello e ntle, e boetse e tsejoa e le "super astragalus polysaccharide".
1.Enhance immune immune le ho hanyetsa mafu.
E ka qhelela ka thoko ka ho hlaka le ka mokhoa o sa khetheheng 'mele oa linaha tse ling tse hlaselang' mele, ea khothalletsa ts'ireletso e khethehileng, ea 'mele ea ho itšireletsa mafung le e sa tobang,' me ea ntlafatsa ho hanyetsa maloetse 'meleng.E ka khothaletsa tlhahiso ea sesole sa 'mele, le ho ntlafatsa haholo palo ea lisele tse etsang li-antibody le boleng ba tlhahlobo ea hemolysis.Astragaloside IV e ka ntlafatsa haholo boemo ba phetoho ea lymphocyte le sekhahla sa sebopeho sa E-rosette ea likhoho tse entetsoeng coccidia.Ke activator e atlehang ea tsamaiso ea monocyte macrophage.Astragaloside IV e ka boela ea ntlafatsa ts'ebetso ea oxidation, GSH-Px le SOD lithong tsa 'mele oa ho itšireletsa mafung, le ho ntlafatsa ts'ireletso ea 'mele ea ho itšireletsa mafung le mesebetsi ea ho lekola sesole sa' mele.
2.Antiviral effect.
Molao-motheo oa eona oa antiviral: ho susumetsa mosebetsi oa macrophages le lisele tsa T, ho eketsa palo ea lisele tse etsang E-ring, ho susumetsa li-cytokine, ho khothalletsa ho kenngoa ha interleukin, 'me ho etsa hore' mele oa phoofolo o hlahise interferon e sa feleng, e le ho finyella morero oa antiviral.Liphetho li bonts'itse hore sekhahla sa ts'ireletso ea astragaloside IV ho IBD e ne e le 98.33%, e neng e ka thibela le ho phekola IBD ka nepo, 'me ho ne ho se na phapang e kholo ha e bapisoa le tharollo e phahameng ea lehe la boits'ireletso ba mmele.Astragaloside e ka ntlafatsa ts'ebetso ea li-enzyme tsa antioxidant 'meleng, ea fokotsa litaba tsa LP0, ea fokotsa tšenyo ea mefuta ea oksijene e sebetsang, kahoo ea fokotsa sekhahla sa liketsahalo le lefu la MD.E ka ntlafatsa ts'ebetso e tlase ea 'mele ea ho itšireletsa mafung e bakoang ke hlahala, ea khothaletsa ts'ebetso ea lisele tsa' mele oa ho itšireletsa mafung, ea lokolla lintlha tse sa feleng, 'me ea thibela ho bolaea le ho thibela lisele tsa hlahala tse bakoang ke peroxidation;Astragaloside a ka thibela kholo ea vaerase ea ntaramane le ts'ebetso ea sialidase.E na le phello e kholo ts'ebetsong ea lisele tsa kokoana-hloko ea ntaramane le ho ata le ho kenella ha kokoana ho lisele tse bonolo.Sekhahla sa ho shoa le ho behoa ha mahe a likhoho se ile sa fokotseha haholo, 'me sekhahla sa ho behela lehe le ho hlaphoheloa ha boleng ba khetla e ne e le molemo haholo ho feta sehlopha sa taolo ea amantadine feela,' me phello ea Astragalus polysaccharide e ne e sa totobala;Astragaloside IV e na le litlamorao tse matla tsa ho bolaea le tse thibelang kokoana-hloko.Sepheo ke hore tšebeliso ea astragaloside IV ke pele ho sibolloa ha tšoaetso ea Nd kokoana-hloko, kahoo ho molemo ho sebelisa astragaloside IV ka nako e telele, Avian myeloblastic leukemia (AMB) matsatsi a 3 a AA broilers a fepa astragaloside IV ka tšoaetso. ea kokoana-hloko ea AMB, e ka fokotsa sekhahla sa ts'oaetso le lefu la AMB, ea eketsa litaba tsa LPO lithong tsa 'mele tsa ho itšireletsa mafung tse kang spleen le thymus, haholo-holo ho ntlafatsa phello ea ho senya ea spleen le thymus le litho tse ling tsa' mele tsa 'mele tsa ho itšireletsa mafung ho lisele tsa tumor tse nkiloeng ho myeloid.Taba ea bobeli, astragaloside IV e na le litlamorao tse hlakileng tsa thibelo le kalafo ho mafu a phefumoloho a kang a tšoaetsanoang laryngotracheitis.Sebelisa.
3. Phello e khahlanong le khatello ea kelello.
Astragaloside IV e ka thibela adrenal hyperplasia le thymus atrophy nakong ea temoso ea karabelo ea khatello ea maikutlo, le ho thibela liphetoho tse sa tloaelehang nakong ea ho hanyetsa le nako ea ho hloleha ha karabelo ea khatello ea maikutlo, e le ho bapala karolo e khahlanong le khatello ea maikutlo, haholoholo e na le taolo ea bohlokoa ea litsela tse peli. phello ea li-enzyme ts'ebetsong ea metabolism ea limatlafatsi, 'me e fokotsa le ho felisa tšusumetso ea khatello ea mocheso mosebetsing oa' mele oa 'mele ho isa tekanyong e itseng.
4. Joaloka motšehetsi oa kholo.
E ka matlafatsa metabolism ea 'mele ea lisele, ea khothalletsa phallo ea mali, ea ntlafatsa metabolism ea' mele oa liphoofolo, 'me ea bapala karolo ea phepo e nepahetseng le tlhokomelo ea bophelo bo botle.Lipatlisiso li bontša hore e ka khothalletsa kholo ea bifidobacteria le lactic acid baktheria 'me e na le phello ea li-probiotics.
5. Astragaloside IV e ka ntlafatsa mosebetsi oa pelo.
Matlafatsa konteraka ea pelo, sireletsa myocardium le ho thibela ho hloleha ha pelo.E boetse e na le liphello tsa ho sireletsa sebete, anti-inflammatory le analgesic.E ka sebelisoa e le kalafo ea adjuvant bakeng sa mafu a fapaneng a vaerase le baktheria.
