Chlorogenic Acid CAS No.327-97-9
Boitsebiso ba Bohlokoa
Asiti ea Chlorogenic e na le mefuta e mengata ea litlamorao tsa antibacteria, empa e ka emisoa ke liprotheine ka har'a vivo.Ho tšoana le caffeic acid, ente ea molomo kapa ea intraperitoneal e ka ntlafatsa thabo e bohareng ea likhoto.E ka eketsa peristalsis ea mala ea likhoto le litoeba le tsitsipano ea popelo ea likhoto.E na le phello ea cholagogic mme e ka ntlafatsa secretion ea bile ho likhoto.E na le phello ea sensitization ho batho.Asma le dermatitis li ka hlaha ka mor'a ho hema lerōle la semela le nang le sehlahisoa sena.
Lebitso la Sechaena: Asiti ea Chlorogenic
Lebitso la kantle: Asiti ea Chlorogenic
Mokhoa oa lik'hemik'hale: C16H18O9
Boima ba 'mele: 354.31
CAS No.: 327-97-9
Sebaka se qhibilihang: 208 ℃;
Sebaka se belang: 665 ℃;
Boima: 1.65 g / cm ³
Sebaka sa Flash: 245.5 ℃
Refractive Index: - 37 °
Lintlha tsa Toxicology
Chefo e matla: tekanyo e fokolang e bolaeang (khoto, sekoti sa mpa) 4000mg / kg
Boitsebiso ba Ecological
Liphello tse ling tse kotsi: ntho e ka 'na ea e-ba kotsi tikolohong,' me tlhokomelo e khethehileng e lokela ho lefshoa 'meleng oa metsi.
Mohloli
Eucommia ulmoides Oliv Lonicera dasytyla Rehd Lipalesa tse omisitsoeng kapa lipalesa tse thunyang, litholoana tsa British Hawthorn ho Rosaceae, cauliflower ho dioscoreaceae, Salix mandshurica ho Apocynaceae, Polypodiaceae semela sa Eurasian water keel rhizomenia le semela sa metsi sa Eurasian keel rhizopace rhizomenia le metsi , Polygonaceae plant flat storage all grass, Rubiaceae plant tarpaulin whole grass, honeysuckle plant capsule Zhai Whole grass.Makhasi a litapole a lelapa la Convolvulaceae.Peo ea kofi e nyane ea litholoana, kofi ea litholoana tse mahareng le kofi e kholo ea litholoana.Makhasi le metso ea Arctium lappa
Tšebeliso ea chlorogenic acid
Chlorogenic acid e na le mesebetsi e mengata ea tlhaho.Lipatlisiso mabapi le mesebetsi ea tlhaho ea chlorogenic acid ho saense ea morao-rao e kene ka botebo likarolong tse ngata, tse kang lijo, tlhokomelo ea bophelo bo botle, meriana, indasteri ea lik'hemik'hale ea letsatsi le letsatsi joalo-joalo.Chlorogenic acid ke ntho ea bohlokoa ea bioactive, e nang le mesebetsi ea antibacterial, antiviral, ho eketsa leukocyte, ho sireletsa sebete le gallbladder, anti-tumor, ho theola khatello ea mali, ho theola lipids tsa mali, ho senya li-radicals tsa mahala le ho thabisa tsamaiso ea methapo e bohareng.
Antibacterial le antiviral
Eucommia ulmoides chlorogenic acid e na le litlamorao tse matla tsa antibacterial le anti-inflammatory, aucubin le li-polymers tsa eona li na le litlamorao tse hlakileng tsa antibacteria, 'me aucubin e na le litlamorao tse thibelang likokoana-hloko tsa Gram-negative le tse ntle.Aucubin e na le liphello tsa bacteriostatic le diuretic, 'me e ka khothalletsa pholiso ea maqeba;Aucubin le glucoside le tsona li ka hlahisa phello e hlakileng ea antiviral kamora setso sa pele, empa ha e na ts'ebetso ea antiviral.The Institute of aging Medical Sciences, Aichi Medical University, e tiisitse hore ntho ea alkaline e ntšitsoeng ho Eucommia ulmoides Oliv.E na le bokhoni ba ho senya kokoana-hloko ea tsamaiso ea 'mele ea ho itšireletsa mafung.Sehlahisoa sena se ka sebelisoa ho thibela le ho alafa AIDS.
Antioxidation
Chlorogenic acid ke phenolic antioxidant e sebetsang.Matla a eona a antioxidant a matla ho feta caffeic acid, p-hydroxybenzoic acid, ferulic acid, syringic acid, butyl hydroxyanisole (BHA) le tocopherol.Chlorogenic acid e na le phello ea antioxidant hobane e na le palo e itseng ea R-OH radical, e ka etsang hydrogen radical le antioxidant effect, e le ho felisa mosebetsi oa hydroxyl radical, superoxide anion le li-radicals tse ling tsa mahala, e le ho sireletsa lisele ho tloha ho oxidative. tshenyo.
Free radical scavenging, anti-botsofali, anti-musculoskeletal aging
Asiti ea Chlorogenic le lintho tse tsoang ho eona li na le phello e matla ea mahala ea radical scavenging ho feta ascorbic acid, caffeic acid le tocopherol (vithamine E), e khona ho qhekella DPPH mahala radical, hydroxyl free radical le superoxide anion free radical, hape e ka thibela oxidation ea low-density. lipoprotein.Chlorogenic acid e bapala karolo ea bohlokoa ho hloekiseng li-radicals tsa mahala, ho boloka sebopeho le ts'ebetso e tloaelehileng ea lisele tsa 'mele, ho thibela le ho liehisa ho hlaha ha hlahala le botsofali.Eucommia chlorogenic acid e na le karolo e khethehileng e ka khothalletsang ho qaptjoa le ho bola ha collagen letlalong la motho, lesapo le mesifa.E na le ts'ebetso ea ho potlakisa metabolism le ho thibela ho fokotseha.E ka sebelisoa ho thibela ho fokotseha ha masapo le mesifa ho bakoang ke ho hloka boima ba sebaka.Ka nako e ts'oanang, ho fumaneha hore Eucommia chlorogenic acid e na le phello e hlakileng ea anti free radical ka bobeli ho vivo le in vitro.
Thibelo ea phetoho le li-antitumor
Liteko tsa morao-rao tsa meriana li pakile hore Eucommia ulmoides chlorogenic acid e na le litlamorao tsa anti-cancer le anti-cancer.Litsebi tsa Majapane li ithutile antimutagenicity ea Eucommia ulmoides chlorogenic acid 'me li fumane hore phello ena e amana le likaroloana tsa anti mutagenic tse kang chlorogenic acid, e senola bohlokoa ba bohlokoa ba chlorogenic acid ho thibela hlahala.
Polyphenols meroho le litholoana, tse kang chlorogenic acid le caffeic acid, li ka thibela mutagenicity ea carcinogens aflatoxin B1 le benzo [a] - pyrene ka ho thibela li-enzyme tse sebetsang;Chlorogenic acid e ka boela ea finyella liphello tse khahlanong le mofetše le li-anti-cancer ka ho fokotsa tšebeliso ea li-carcinogens le lipalangoang tsa tsona sebeteng.Chlorogenic acid e na le litlamorao tse kholo tse thibelang mofetše oa mala, mofets'e oa sebete le mofets'e oa laryngeal.E nkoa e le sesebelisoa se sebetsang sa lik'hemik'hale se sireletsang khahlanong le kankere.
Tšireletso e matla tsamaisong ea pelo
Joalo ka sehlaseli sa mahala sa radical le antioxidant, chlorogenic acid e pakiloe ke liteko tse ngata.Mosebetsi ona oa likokoana-hloko oa chlorogenic acid o ka sireletsa tsamaiso ea pelo.Isochlorogenic acid B e na le phello e matla ea ho khothalletsa ho lokolloa ha prostacyclin (PGI2) le anti platelet aggregation ho likhoto;Sekhahla sa thibelo ea ho lokolloa ha SRS-A e hlahisitsoeng ke antibody ho maloanlahla a matšoafo a guinea pig e ne e le 62.3%.Isochlorogenic acid C e boetse e khothalletsa ho lokolloa ha PGI2.Ho phaella moo, isochlorogenic acid B e na le phello e matla ea ho thibela platelet thromboxane biosynthesis le kotsi ea endothelin e bakoang ke hydrogen peroxide.
Phello ea Hypotensive
Ho 'nile ha pakoa ke lilemo tse ngata tsa liteko tsa kliniki hore Eucommia chlorogenic acid e na le phello e hlakileng ea antihypertensive, phello e tsitsitseng ea phekolo, e seng chefo ebile ha e na litla-morao.Univesithi ea Wisconsin e fumane hore likarolo tse sebetsang tsa Eucommia ulmoides tala ho fokotsa khatello ea mali ke terpineol diglucoside, aucubin, chlorogenic acid, le Eucommia ulmoides chlorogenic acid polysaccharides.[5]
Mesebetsi e meng ea likokoana-hloko
Hobane chlorogenic acid e na le phello e khethehileng ea ho thibela hyaluronic acid (HAase) le glucose-6-phosphatase (gl-6-pase), chlorogenic acid e na le phello e itseng pholisong ea maqeba, bophelo bo botle ba letlalo le ho koloba, manonyeletso, ho thibela ho ruruha le ho ruruha. ho leka-lekanya taolo ea tsoekere ea mali 'meleng.Chlorogenic acid e na le litlamorao tse matla tsa ho thibela le ho bolaea mafu a fapaneng le livaerase.Chlorogenic acid e na le litlamorao tsa pharmacological tsa ho theola khatello ea mali, antibacterial, antiviral, anti-inflammatory, ho eketsa lisele tse tšoeu tsa mali, ho thibela lefu la tsoekere, ho eketsa motility ea mala le ho khothaletsa secretion ea mala.Liphuputso li bontšitse hore oral chlorogenic acid e ka susumetsa haholo secretion ea bile 'me e na le phello ea ho thusa gallbladder le ho sireletsa sebete;E ka boela ea thibela ka katleho hemolysis ea rat erythrocyte e bakoang ke H2O2.
