Cycloastragenol CAS No. 78574-94-4
Tlhaloso ea Sehlahisoa
[lebitso]:joala ea cycloastragalus
[litlhaloso tse ling]:triterpenoid cyclic flavonol
[Lebitso la Senyesemane]:cycloastragenol
[molek'hule]:C30H50O5
[boima ba molek'hule]:490.71
[Nomoro ea CAS]:78574-94-4
[mokhoa oa ho lemoha]:HPLC ≥ 98%
[Tlhaloso]:20mg 50mg 100mg 500mg 1g (e ka pakoa ho latela litlhoko tsa bareki)
[thepa]:sehlahisoa sena ke kristale ea acicular e se nang 'mala
[ts'ebetso le ts'ebeliso]:Sehlahisoa sena se sebelisetsoa ho fumana litaba, ho tsebahatsa, liteko tsa meriana, tlhahlobo ea liketsahalo le liteko tse ling tsa lipatlisiso tsa mahlale.Tse kang tsamaiso ea lisele, tlhahlobo ea intragastric, tlhahlobo ea boleng ba ka hare ea fektheri ea meriana, joalo-joaloMohloli: Astragalus membranaceus (Fisch.) Bge.Motso o omisitsoeng
Mokhoa oa ho boloka
2-8 ° C, e koetsoe ho tloha khanyeng 'me e bolokiloe mocheso o tlaase.
Hlokomela
Sehlahisoa sena se lokela ho bolokoa ka mocheso o tlase.Haeba e pepesehetse moea ka nako e telele, litaba li tla fokotseha.
Chromatographic conditions} kholomo ea chromatographic: Zorbax rx-c18 (4.6mm) × 150mm)，5 μ m; Mohato oa selefouno: metsi a acetonitrile (30:70);Sekhahla sa phallo: 1.0ml/min, mocheso oa kholomo: 35 ℃, litekanyetso tsa ELSD: mocheso oa tube ea drift: 105 ℃, sekhahla sa phallo ea naetrojene: 2.70ml/min.
Thepa ea Physicochemical: boima ba 1.20
Bioactivity ea cycloastragenol
Cycloastragalol ke motsoako oa triterpene saponin, e leng Astragalus membranaceus (Fisch.) Hydrolyzate ea motsoako o sebetsang oa Bunge).Astramembrangenin e na le tšireletseho ea molomo mme e na le litlamorao tse ngata tsa pharmacological, ho kenyelletsa ts'ebetso ea telomerase, prolongation ea telomere, anti-inflammatory le antioxidant thepa.Astramembrangenin e na le lintho tse thibelang botsofali.CAG e susumetsa ts'ebetso ea telomerase ho keratinocyte e sa tsoa tsoaloa ea batho le lisele tsa methapo ea likhoto mme e kenya tšebetsong CREB.Astramembrangenin e kanna ea ba le phello e ncha ea kalafo khatellong ea maikutlo
Likarolo tse Amanang:
Tsela ea matshwao > > apoptosis > > apoptosis
Sebaka sa lipatlisiso>> ho ruruha / ho itšireletsa mafung
Sebaka sa lipatlisiso > > mafu a methapo ea kutlo
Thuto ea In Vitro:
Ha ho bapisoa le taolo ea sephethephethe moetlong oa HEK, protheine ea membrane ea linaleli (0-10 μ M; matsatsi a 3-6) e ile ea eketsa kholo ea lisele [1].Astramembrangenin (0.3 μ M;Metsotso ea 5-90) e kentse phosphorylation ea CREB ho li-neuron tsa mantlha tsa cortical, mme polelo ea CREB e felletseng mefuteng ka bobeli ea lisele ha ea angoa ke CAG [1].Protheine ea membrane ea linaleli (3) μ M;Lihora tsa 6-48) li ka khothaletsa phetisetso ea lets'oao la vivo ho li-neurone, tsa eketsa polelo ea TERT mRNA, le ho bonts'a polelo e eketsehileng ea bcl 2 mRNA [1].Cell assay assay [1] cell line: HEK cell concentration: 1 μ M, 3 μ M, 10 μ M nako ea setso: 3-6 matsatsi a liphello: kholo ea lisele e imenne habeli matsatsing a 6.Tlhahlobo ea blot ea Bophirimela [1] selefouno: mahloriso a lisele tsa neuron: 0.3 μ M nako ea setso: metsotso e 5, metsotso e 15, metsotso e 30, metsotso e 90.Liphello: CAG e kentse ts'ebetso ea CREB ho li-neurons.RT-PCR [1] mohala oa sele: mahloriso a lisele tsa neuron: 3 μ M nako ea setso: lihora tsa 6-48 liphetho: polelo ea TERT le Bcl 2 mRNA e eketsehile.
Referense:
[1].Ip FC, le ba bang.Cycloastragenol ke activator e matla ea telomerase liseleng tsa neuronal: litlamorao bakeng sa taolo ea khatello ea maikutlo.Li-neurosignals.2014;22(1):52-63.
[2].Yu Y, le ba bang.Cycloastragenol: Moqapi oa lipale tse monate bakeng sa mafu a amanang le lilemo.Exp Ther Med.2018 Sep;16(3):2175-2182.
[3].Sun C, le ba bang.Cycloastragenol e sebelisana le ts'ebetso le khatello ea ho ata ho concanavalin A-induced mouse lymphocyte pan-activation model.Immunopharmacol Immunotoxicol.2017 Jun; 39 (3): 131-139.
Thepa ea Physicochemical ea Cycloastragenol
Tekano:1.2 ± 0.1 g / cm3
Sebaka se belang:617.2 ± 55.0 ° C ho 760 mmHg
Sebaka sa ho qhibiliha:241.0 ho isa ho 245.0 ° C
Foromo ea molek'hule:c30h50o5
Boima ba molek'hule:490.715
Flash point:327.1 ± 31.5 ° C
Boima bo nepahetseng:490.365814
PSA:90.15000
LogP:3.82
Khatello ea mouoane:0.0 ± 4.0 mmHg ho 25 ° C
Lenane la Refractive:1.582
Boitsebiso ba Tšireletso ea Cycloastragenol
Khoutu ea lipalangoang ea thepa e kotsi: nonh bakeng sa mefuta eohle ea lipalangoang
nomoro ea RTECS;GX8265000
Meetlo Code: 2942000000
Litloaelo tsa Cycloastragalol
Meetlo Code: 2942000000
Lingoliloeng tsa Cycloastragalol
Cycloastragenol ke activator e matla ea telomerase liseleng tsa neuronal: litlamorao bakeng sa taolo ea khatello ea maikutlo.
Neurosignals 22(1) , 52-63, (2014)
Cycloastragenol (CAG) ke aglycone ea astragaloside IV.E qalile ho tsejoa ha ho hlahlojoa li-extracts tsa Astragalus membranaceus bakeng sa metsoako e sebetsang e nang le thepa e thibelang botsofali.Thuto ea hajoale ea ...
Novel telomerase activator e hatella tšenyo ea matšoafo ka mohlala oa murine oa idiopathic pulmonary fibrosis.
PLoS ONE 8(3) , e58423, (2013)
Ho hlaha ha mafu a amanang le ho se sebetse ha telomere, ho kopanyelletsa le AIDS, aplastic anemia le pulmonary fibrosis, ho matlafalitse thahasello ho li-activator tsa telomerase.Re tlaleha boitsebiso ba n...
Matlafatso ea pharmacologic e thehiloeng ho telomerase ea ts'ebetso ea antiviral ea li-lymphocyte tsa CD8+ T tsa motho.
J. Immunol.181(10) , 7400-6, (2008)
Telomerase reverse e ngola telomere DNA lipheletsong tsa linear chromosomes le ho khina botsofali ba lisele.Ho fapana le lisele tse ngata tse tloaelehileng tsa somatic, tse bonts'ang ts'ebetso ea telomerase e nyane kapa e se nang letho, immunos ...
Lebitso la Senyesemane la Cycloastragalol
9,19-Cyclolanostane-3,6,16,25-tetrol,20,24-epoxy-,(3β,6α,9β,16β,20R,24S)-
Astramembrangenin
(3β,6α,9β,16β,20R,24R)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol
19-Cyclolanostane-3,6,16,25-tetrol,20,24-epoxy-,(3β,6α,9β,16β,20R,24R)-
(3β,6α,9β,16β,20R,24S)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol
Cyclosieversigenin
Cyclogalegegenin
