Lihlahisoa

Tlhaloso:Danshensu ke karolo e sebetsang ea Salvia miltiorrhiza, e ka kenyang tsela ea pontšo ea Nrf2 le ho sireletsa tsamaiso ea pelo.
Likarolo tse Amanang: tsela ea matšoao > > autophagy > > autophagy
Tsela ea matshwao > > NF- κ B tsela ya letshwao > > keap1-nrf2
Sebaka sa lipatlisiso > > lefu la pelo
Lihlahisoa tsa Tlhaho > > li-benzoic acid

Thuto ea In Vitro:Danshensu (DSS) e fokolitse haholo litekanyetso tsa lik'hemik'hale tsa lik'hemik'hale (creatine kinase le lactate dehydrogenase) ea coronary outflow le boholo ba infarction ea myocardial.Sena se ka khothaletsa pholiso ea ts'ebetso ea pelo ka mor'a kotsi ea I / R.DSS e boetse e na le ts'ebetso ea ho senya ea ROS mme e khothalletsa ts'ebetso ea li-antioxidants tse sa feleng tse kang SOD, cat, MDA, GSH-Px le HO-1 ka ho kenya tšebetsong tsela ea pontšo e amanang le nuclear factor erythrocyte-2 (Nrf2) e kentsoeng ke Akt le ERK1.2 tlhahlobong ea blot ea Bophirimela [2].

Thutong ea Vivo:Kalafo e matla ka tekanyo e le 'ngoe ea Danshensu ha ea ka ea fetola plasma tHcy ho likhoto tse nang le tHcy e tloaelehileng.Ka lehlakoreng le leng, Danshensu e fokolitse tHcy haholo likhotong tse nang le tHcy e phahameng.Litekanyo tse batlang li phahame tsa cysteine ​​​​le glutathione ka mor'a phekolo le Danshensu li bontša hore phello ea eona ea ho fokotsa tHcy ke ka ho eketsa mosebetsi oa trans vulcanization pathway [1].

Liteko tsa Liphoofolo:lik'hemik'hale tsohle li ne li qhibiliha ka letsoai ntle le tolcapone e qhibilihisitsoeng ka letsoai e nang le 20% (V / V) peg 200. Nakong ea teko, likhoto li ne li itima lijo bosiung bo le bong 'me li abeloa lihlopha tse fapaneng ka nako e sa lekanyetsoang.Ka mor'a anesthesia ea ether, hoo e ka bang 200 e ile ea ntšoa maling a orbital sinus μ L, ebe ka potlako e bolaea likokoana-hloko ka joala ebe o tobetsa ka k'hothone.Lisampole tsa mali li ile tsa bokelloa hang-hang ka har'a li-polypropylene tubes tse nang le sodium ea heparin le centrifuged ho 5000 g ho 5 ° C metsotso e 3.Mehlala e lokisitsoeng ea plasma e bolokiloe ho -20 ℃ mme e hlahlojoe nakong ea lihora tse 48.

Litšupiso:[1] YG Cao, et al.Liphello tse ntle tsa danshensu, karolo e sebetsang ea Salvia miltiorrhiza, ho metabolism ea homocysteine ​​​​ka tsela ea trans-sulphuration ho likhoto.Br J Pharmacol.2009 Jun;157(3): 482–490.

[2].Yu J, le ba bang.Danshensu e sireletsa pelo e ka thōko khahlanong le kotsi ea ho tsosolosoa ha ischemia ka ho kenya tšebetsong pontšo ea Akt/ERK1/2/Nrf2.Int J Clin Exp Med.2015 Sep 15;8(9):14793-804.