Fraxin;Paviin;Fraxoside;Fraxetol- 8-glucoside CAS No.524-30-1
Boitsebiso ba Bohlokoa
Nomoro ea CAS:524-30-1 [1]
Nomoro ea EINECS:208-355-5
Foromo ea molek'hule:c16h18o10
Boima ba Molek'hule:370.3081
Sebopeho sa Molek'hule:(Setšoantšo sa 1)
Thepa:Kristale e khanyang e mosehla acicular kapa kristale ea flake.
Tekano:1.634g/cm3
Sebaka sa ho Bela:722.2 ° C ho 760 mmHg
Flash point:267 ° C
Khatello ea Mouoane:6.87e-22mmhg ho 25 ° C
Bioactivity ea Fraxin
Tlhaloso:Fraxin e ka aroloa ho Acer tegmentosum, F. ornus le a.hippocastanum.Ke glycoside ea fraxine [1] 'me e na le mesebetsi ea antioxidant, anti-inflammatory le anti metastasis.Fraxin e bonts'a ts'ebetso ea antioxidant ka ho thibela cyclic adenylate phosphodiesterase [2].
Sepheo:cyclo AMP phosphodiesterase enzyme [2]
Thuto ea In Vitro:Fraxin (100 μ M) Ha e na cytotoxicity ho lisele tsa Hep G2.Fraxin maemong a se nang cytotoxic e fokolitse haholo tlhahiso ea t-BHP e hlahisitsoeng ke ROS ka mokhoa o itšetlehileng ka lethal dose [1].Fraxin (0.5 limilimithara) e ka senya li-radicals tsa mahala maemong a phahameng haholo 'me e na le phello ea cytoprotective ho khatello ea oxidative ea H2O2 e bohareng [2].
Thuto ea in vivo:Fraxin (50 mg / kg, PO) e thibetse haholo ho phahama ha CCl4 ea ALT le AST.Fraxin (10 le 50 mg / kg, PO) e fokolitse haholo maemo a GSSG (1.7 ± 0.3 le 1.5 ± 0.2 nm / g sebete, ka ho latellana) ha e bapisoa le maemo a GSSG sehlopheng sa phekolo ea CCl4.
Referense:.Fraxin (50 mg / kg, po) e thibela haholo ho phahama ha CCl4 ea ALT le AST.Fraxin (10 le 50 mg/kg, po) e fokotsa haholo maemo a GSSG (1.7±0.3 le 1.5±0.2 nM/g sebete, ka ho latellana) ha a bapisoa le maemo a GSSG a sehlopha sa phekolo ea CCl4 [1].
[2].Whang WK, et al.Metsoako ea tlhaho, fraxin le lik'hemik'hale tse amanang le fraxin li sireletsa lisele khatellong ea oxidative.Exp Mol Med.2005 Oct 31;37(5):436-46.
