Galangin CAS No. 548-83-4
Lintho tsa 'mele le tsa lik'hemik'hale
Leetsi:Gaoliang Curcumin;3,5,7-trihydroxyflavone,
Lebitso la Senyesemane:galangin,
Lebitso la Senyesemane:3,5,7-trihydroxyflavone;3,5,7-trihydroxy-2-phenylchromen-4-one
Sebopeho sa limolek'hule
1. Molar refractive index: 69,55
2. Molumo oa Molar (m3 / mol): 171.1
3. Molumo o khethehileng oa Isotonic (90.2k): 519.4
4. Khatello ea sefahleho (dyne / cm): 84.9
5. Polarizability (10-24cm3): 27.57
Computational Chemistry
1. Reference value for hydrophobic parameter calculation (xlogp): Ha ho letho
2. Palo ea bafani ba bond ea haedrojene: 3
3. Palo ea li-receptor tsa hydrogen bond: 5
4. Palo ea libonto tsa lik'hemik'hale tse rotatable: 1
5. Palo ea li-tautomer: 24
6. Topological molecular polarity surface area 87
7. Palo ea liathomo tse boima: 20
8. Tefiso ea bokaholimo: 0
9. Ho rarahana: 424
10. Palo ea liathomo tsa isotopic: 0
11. Fumana palo ea li-stereocenter tsa athomo: 0
12. Palo ea li-stereocenter tse sa tsitsang tsa athomo: 0
13. Fumana palo ea li-chemical bond stereocenters: 0
14. Palo ea li-indeterminate chemical bond stereocenters: 0
15. Palo ea li-covalent bond units: 1
Ketso ea Pharmacological
Galangin e ka fetola Salmonella typhimurium TA98 le TA100 mme e na le phello ea antiviral.
Thuto ea In Vitro
Galangin e thibetse catabolism ea DMBA ka mokhoa o itšetlehileng ka tekanyetso.Galangin e boetse e thibela ho thehoa ha li-adducts tsa DMBA-DNA le ho thibela DMBA ho thibela kholo ea lisele.Liseleng tse tiileng le li-microsomes tse arohaneng le lisele tse tšoaroang tsa DMBA, galangin e hlahisitse thibelo e sebetsang e itšetlehileng ka tekanyo ea CYP1A1 e lekantsoeng ka mosebetsi oa ethoxypurine-o-deacetylase.Tlhahlobo ea kinetics ea inhibition ka setšoantšo se habeli se bonts'a hore galangin e thibela ts'ebetso ea CYP1A1 ka mokhoa o se nang tlholisano.Galangin e lebisa ho eketseha ha boemo ba CYP1A1 mRNA, e bontšang hore e ka 'na ea e-ba agonist ea monko o monate oa hydrocarbon receptor, empa e thibela CYP1A1 mRNA (TCDD) e hlahisoang ke DMBA kapa 2,3,5,7-tetrachlorodibenzo-p-dioxin.Galangin e boetse e thibela ho ngoloa ha DMBA kapa TCDD ho li-vector tsa moqolotsi tse nang le CYP1A1 promotor [1].Kalafo ea Galangin e ile ea thibela ho ata ha lisele le ho susumetsa autophagy (130) μ M) Le apoptosis (370 μ M) Haholo-holo, phekolo ea galangin liseleng tsa HepG2 e ile ea fella ka (1) ho bokella li-autophagosomes, (2) ho eketseha ha maemo a microtubule a amanang le ketane ea leseli la protheine. 3, le (3) liperesente tse eketsehileng tsa lisele tse nang le li-vacuoles Polelo ea P53 e boetse e eketsehile. [2].
Teko ea Cell
Lisele (5.0 × 103) li kenngoa le ho phekoloa ka mefuta e sa tšoaneng ea galangin ka lipoleiti tsa seliba tse 96 ka linako tse fapaneng.Ka ho eketsa 10 μ L ea 5 mg / ml MTT tharollo ho fumana palo ea lisele tse phelang selibeng ka seng.Ka mor'a ho kenngoa ka 37 ℃ lihora tse 4, lisele li ile tsa qhibiliha ka tharollo ea 100% e nang le 20% SDS le 50% dimethylformamide μ L tharollo.Boima ba mahlo bo ile ba lekanyetsoa ho sebelisoa spectrophotometer ea varioskan flash ea wavelength ea 570 nm le wavelength ea referense ea 630 nm.
