Lihlahisoa

Tlhaloso:glucoridin ke isoflavane e tsoang ho glycorrhiza glabra, e ka tlamang le ho kenya tšebetsong PPAR γ， Boleng ba EC50 ke 6115 nm.Glabridin e na le antioxidant, antibacterial, anti glomerulonephritis, anti-diabetes, anti-tumor, anti-inflammatory, anti osteoporosis, e sireletsa pelo, e sireletsa methapo, e senya li-radicals tsa mahala le mesebetsi e meng.

Lihlopha tse amanang:lefapha la lipatlisiso > > kankere
Tsela ea lipontšo>> potoloho ea lisele / tšenyo ea DNA>> PPAR
Sebaka sa lipatlisiso>> ho ruruha / ho itšireletsa mafung

Thuto ea In Vitro:glabridin e tlama le ho kenya tšebetsong PPAR γ, EC50 ke 6115 nm [1].Glabridin (40,80 μ M) Ho ata ha lisele tsa SCC-9 le SAS ho ne ho thibetsoe ka tekanyo le nako e itšetlehileng ka nako ka mor'a lihora tse 24 le 48 tsa phekolo [2].Glabridin (0-80 μ M) E boetse e etsa hore ho be le apoptosis, e lebisang ho ts'oaroe ha lisele tsa G1 ho SCC-9 le SAS cell lines [2].Glabridin (0,20,40 le 80 μ M) Lethal dose itšetlehile ka activated Caspase-3, - 8 le - 9 le eketseha PARP cleavage, haholo phosphorylating ERK1 / 2, JNK1 / 2 le P-38 MAPK ka SCC-9.Lisele [2].

Thutong ea Vivo:glabridin (50 mg / kg, Po hang ka letsatsi) e bontšitse ts'ebetso e matla e khahlanong le ho ruruha le ho ntlafatsa liphetoho tsa ho ruruha tse bakoang ke dextran sodium sulfate (DSS) [3]

Litšupiso:[1] Rebhun JF, le ba bang.Ho tsebahatsa glabridin e le motsoako oa bioactive ka har'a licorice (Glycyrrhiza glabra L.) qotsulo e etsang hore motho a sebelise peroxisome proliferator-activated receptor gamma (PPAR γ).Fitoterapia.2015 Oct;106:55-61 .
[2].Chen CT, le ba bang.Glabridin e etsa hore ho be le apoptosis le ho tšoaroa ha lisele tsa kankere ea molomo ka tsela ea pontšo ea JNK1/2.Tikoloho ea Toxicol.2018 Jun;33(6):679-685.
[3].El-Ashmawy NE, le ba bang.Ho fokotseha ha iNOS le ho phahama ha kampo ho kopanya phello e khahlanong le ho ruruha ea glabridin ho likhoto tse nang le lefu la ulcerative colitis.Inflammopharmacology.2018 Mmesa;26(2):551-559.