Hyperoside;Hypercin Cas No. 482-36-0
Boitsebiso ba Lithethefatsi
[lebitso la sehlahisoa] hypericin
[Lebitso la Senyesemane] Hyperoside
[alias] hyperin, quercetin 3-galactoside, quercetin-3-o-galactoside
[formula ea molek'hule] c21h20o12
[boima ba molek'hule] 464.3763
[C joalo ka No.] 482-36-0
[karolo ea lik'hemik'hale] flavonoids
[mohloli] Hypericum perforatum L
[Tlhaloso] > 98%
[Mareo a Polokeho] 1. Se hema lerole.2.Ha ho hlaha kotsi kapa ho se thabise, batla thuso ea bongaka hang-hang (bontša lengolo la eona haeba ho khoneha).
[Tlhahiso ea Pharmacological] Hypericin e ajoa haholo.Ke sehlahisoa sa bohlokoa sa tlhaho se nang le mefuta e sa tšoaneng ea mesebetsi ea 'mele, e kang ho thibela ho ruruha, antispasmodic, diuretic, ho fokotsa khohlela, ho fokotsa khatello ea mali, ho fokotsa k'holeseterole, ho ts'oaroa ha protheine, analgesia ea sebakeng le bohareng, le liphello tse sireletsang methapong ea pelo le ea boko.
[Thepa ea 'mele le ea lik'hemik'hale] Khalase e khanyang e mosehla acicular.Sebaka se qhibilihang ke 227 ~ 229 ℃, 'me ho potoloha ha optical ke - 83 ° (C = 0.2, pyridine).E qhibiliha habonolo ka ethanol, methanol, acetone le pyridine 'me e tsitsitse tlas'a maemo a tloaelehileng.E arabela ka hydrochloric acid magnesium phofo ho hlahisa cherry e khubelu, 'me ferric chloride e arabela ka botala, α- Naphthol reaction e ne e le ntle.
[Mantsoe a kotsi] E kotsi haeba e koetsoe.
Ketso ea Pharmacological
1. Hypericin e na le phello ea bohlokoa ea analgesic ea sebakeng seo, e fokolang ho feta morphine, e matla ho feta aspirin, 'me ha e itšetlehe ka letho.Hypericin ke mofuta o mocha oa li-analgesic tsa lehae Ka nako e ts'oanang,
2. Hypericin e na le phello e ntle ea tšireletso ho myocardial ischemia-reperfusion, cerebral ischemia-reperfusion le cerebral infarction.
3. Hypericin e na le phello e hlakileng e khahlanong le ho ruruha: ka mor'a ho kenngoa ha bolo ea boea, likhoto li ne li kenngoa ka intraperitoneally ka 20mg / kg letsatsi le leng le le leng ka matsatsi a 7, e leng se ileng sa thibela haholo mokhoa oa ho ruruha.
4. E na le phello e matla ea antitussive.
5. Ts'oarelo.
6. Thibelo e matla ea aldose reductase e ka ba molemo ho thibela lefu la tsoekere.
Tšireletso e matla ho myocardial ischemia
Hypericin e ka fokotsa sekhahla sa apoptosis ea cardiomyocyte e bakoang ke hypoxia reoxygenation, e thibela ho lokolloa ha lactate dehydrogenase, ea ntlafatsa mosebetsi oa myocardial superoxide dismutase (SOD) ka likhoto tse nang le kotsi ea myocardial ischemia-reperfusion, ho fokotsa tlhahiso ea malondialdehyde (MDA), thibela keketseho ea myocardial phosphokinase (CPK) ka serum, le ho fokotsa sebopeho sa oksijene mahala radical le nitric oxide mahala radical, E le ho sireletsa myocardium le ho fokotsa kotsi cardiomyocyte le cardiomyocyte apoptosis bakoang ke ischemia-reperfusion.
Tšireletso e matla ho cerebral ischemia
Hypericin e ka thibela ka nepo phokotso ea litaba tsa formazan lilae tsa boko ka mor'a kotsi ea hypoxia ea tsoekere ea hypoxia, ea eketsa palo ea li-neuron tse setseng ka har'a cortex le striatum ea lilae tsa boko sebakeng sa ischemic, le ho etsa hore morphology ea li-neuron e phethehe le ho ajoa hantle.Thibela phokotseho ea tšebetso ea methapo ea kutlo e bakoang ke kotsi ea phokotso ea tsoekere ea hypoxia.Thibela ho fokotseha ha mesebetsi ea SOD, LDH le glutathione peroxidase (GSHPx).Mokhoa oa eona o ka 'na oa amahanngoa le ho senya mahala, ho thibela ho phalla ha Ca2 le ho thehoa ha anti lipid peroxide.
Tšireletso e sireletsa sebeteng le mucosa ea ka mpeng
Hypericin e na le phello e hlakileng ea tšireletso ho lisele tsa sebete le mucosa ea ka mpeng.Mochine oa eona o amana le phello ea antioxidant, e khothalletsang ho khutla ha boemo ba N0 ho ea ho tloaelehileng le ho eketsa ts'ebetso ea SOD.
Matla a antispasmodic analgesic
Boithuto bo fumane hore phello ea analgesic ea hypericin e hlahisoa ka ho fokotsa Ca 2 mapheletsong a methapo e bohloko.Ka nako e ts'oanang, hypericin e ka thibela phallo ea Ca 2 e bakoang ke potasiamo e phahameng, e bontšang hore hypericin e boetse e thibela Ca channel liseleng tsa methapo.Ho boetse ho etsoa tlhahiso ea hore hypericin e ka ba blocker ea mocha oa Ca 2.Tlhahlobo ea bongaka e bontša hore ente ea hypericin e tšoana le ea atropine ha ho phekoloa dysmenorrhea ea mantlha.Ntle le litla-morao tse 'maloa tsa ho otsela, ha e na litlamorao tse tloaelehileng tse joalo ka tachycardia, mydriasis le maikutlo a tukang.Ke antispasmodic e nepahetseng le analgesic.
Phello ea Hypolipidemic
Hypericin e ka fokotsa serum TC haholo mme ea eketsa karo-karolelano ea HDL / TC ho litoeba tse mafura a mangata, ho bonts'a hore hypericin e ka fokotsa k'holeseterole, ea laola lipid ea mali, 'me ea ntlafatsa ts'ebetso ea HDL le serum SOD ho litoeba.Phello ena e ka fokotsa haholo tšenyo ea superoxide mahala radical ho vascular endothelium ka hyperlipidemia, 'me e thusa ho senyeha le metabolism ea lipid peroxide ho sireletsa vascular endothelium.
Ntlafatsa ts'ebetso ea 'mele ea ho itšireletsa mafung
Hypericin ka litekanyetso tsa 300 mg / kg le 150 mg / kg ka vivo e ka thibela haholo index ea thymus, ho ata ha lymphocyte T le B le phagocytosis ea peritoneal macrophages;Ka 59 mg / kg, e matlafalitse haholo ho ata ha spleen T le B lymphocyte le phagocytosis ea peritoneal macrophages.Hypericin ka tekanyo ea 50 ~ 6.25 ml in vitro e ka khothalletsa haholo ho ata ha spleen T le B lymphocyte le ho ntlafatsa bokhoni ba T lymphocyte ho hlahisa IL-2;Hypericin ka 6.25 g / ml haholo e ile ea eketsa bokhoni ba mouse peritoneal macrophages ho phagocytize neutrophils, ho tloha 12,5 ho 3.12 μ G / ml haholo e ile ea eketseha bokhoni ba mouse peritoneal macrophages ho lokolla No.
Phello ea ho imeloa kelellong
Ts'ebetso ea Hypothalamic pituitary adrenal (HPA) ke phetoho e tloaelehileng ea baeloji ho bakuli ba nang le khatello ea maikutlo e matla, e khetholloang ke secretion e feteletseng ea adrenocorticotropic hormone (ACTH) le cortisol.Hypericin e ka laola mosebetsi oa HPA axis le ho fokotsa maemo a ACTH le corticosterone, e le ho phetha karolo ea ho thibela ho tepella maikutlong.
Lithethefatsi Tse Feletseng
Ciwujia capsule
Acanthopanax senticosus capsule ke setlolo se nang le kutu ea Acanthopanax senticosus le lekhasi le ntšitsoeng joalo ka thepa e tala.Karolo e ka sehloohong ke flavonoids, eo ho eona hypericin e leng karolo e ka sehloohong e sebetsang ea makhasi a Acanthopanax senticosus.
Lipontšo tse ka sehloohong: ho khothalletsa ho potoloha ha mali le ho tlosa stasis ea mali.E sebelisetsoa sefuba sa arthralgia le lefu la pelo le bakoang ke stasis ea mali.Matšoao a kenyelletsa bohloko ba sefuba, ho tiea ha sefuba, ho otla ha pelo, khatello ea mali, joalo-joalo ke ho haella ha spleen le liphio le stasis ea mali le Yin.
Xinan capsule
Ke tokisetso e entsoeng ka lekhasi la hawthorn, le nang le flavonoids e ngata, eo ho eona hypericin e leng e 'ngoe ea likarolo tse ka sehloohong.
Matšoao a mantlha: ho holisa tsamaiso ea methapo ea pelo, ho ntlafatsa phepelo ea mali ea myocardial le ho fokotsa lipids tsa mali.E sebelisoa ho phekola lefu la pelo, angina pectoris, ho tiea ha sefuba, ho otla ha pelo, khatello ea mali, joalo-joalo.
Letlapa la Qiyue Jiangzhi
Letlapa la Qiyue Jiangzhi ke moriana o hloekileng oa setso oa Machaena o theolang lipid o lokisitsoeng ka ho ntša likarolo tse sebetsang tsa moriana oa setso oa Machaena joalo ka hawthorn (enucleated) le Astragalus membranaceus.E 'ngoe ea likarolo tse ka sehloohong tse sebetsang tsa hawthorn ke flavonoids, eo ho eona ho nang le hypericin e ngata.
Matšoao a mantlha: fokotsa lipid ea mali le ho nolofatsa methapo ea mali.E sebelisoa ho ntlafatsa phallo ea mali le ho loantša arrhythmia le hyperlipidemia.
Letlapa la Xinxuening
Letlapa la Xinxuening ke motsoako o entsoeng ka meriana ea setso ea Chaena e kang hawthorn le pueraria.Hawthorn ke moriana oa molao oa mokete oa rona.E na le ursolic acid, Vitexin rhamnoside, hypericin, citric acid, joalo-joalo, eo hypericin e leng eona karolo e ka sehloohong.
Lipontšo tse ka sehloohong: ho khothalletsa ho potoloha ha mali le ho tlosa stasis ea mali, ho fokotsa litšireletso le ho kokobetsa bohloko.E sebelisoa bakeng sa sefuba arthralgia le vertigo bakoang ke pelo stasis mali le boko collaterals, hammoho le lefu la pelo, kgatelelo ya madi, angina pectoris le hyperlipidemia.
Yukexin capsule
Yukexin capsule ke moriana oa setso oa Machaena o entsoeng ho tsoa lengolong la khale la ngaka, le entsoeng ka Hypericum perforatum, kernel ea jujube e hlaha, lekhapetla la Albizzia, Gladiolus le meriana e meng ea setso ea Sechaena.Haholo-holo e na le hypericin, quercetin, quercetin, chlorogenic acid, caffeic acid, yimaning, hypericin le likarolo tse ling.
Lipontšo tse ka sehloohong: khatello ea kelello e bakoang ke ho hloka botsitso ha sebete qi le maikutlo a fosahetseng.
