Jujuboside A CAS No. 55466-04-1
Boitsebiso ba Bohlokoa
Lebitso la Sechaena:jujube kernel saponin A, jujube kernel saponin A;Jujube kernel saponin A (e tloaelehileng)
Lebitso la Senyesemane:Jujuboside A
Mohloli oa semela:e tsoa ho peo ea jujube e hlaha, e tsejoang hape e le kernel ea jujube le jujube core
Foromo ea molek'hule:C58H94O26
Boima ba molek'hule:1207.35
Nomoro ea CAS.55466-04-1
Bioactivity ea Jujuboside A
Sepheo:GABA receptor, mTOR, PI3K, Akt [1] [2]
Thuto ea in vitro:tekanyo e tlaase 41 μ Jujuboside A ea M (hoo e ka bang 0.05 g / L) e kentse GABA (a) li-receptor nakong ea phekolo ea 24 le 72 h α 1, α 5, β 2 subunit mRNA e eketsehile haholo.Tekanyo e phahameng ea 82 μ M (hoo e ka bang 0.1 g / L) Jujuboside A e eketsehile haholo GABA (a) li-receptors ho 24 h α 1, α 5 subunit mRNA maemo le ho fokotseha ha β 2 subunit mRNA level le ho fokotseha ha GABA (a) receptor subunit α 1， Polelo ea β 2 mRNA e ile ea phekoloa ka 72 h [1].Jujuboside A pretreatment e ka khutlisa phokotseho ea ts'ebetso ea lisele le ho baka kotsi e betere ea ISO ea H9c2 cell.Jujuboside A e ka potlakisa phosphorylation ea PI3K, Akt le mTOR.Jujuboside A e ka fokotsa haholo karolo ea protheine e amanang le microtubule LC3-II / I liseleng tsa H9c2 [2]
Thuto ea in vivo:motšehare (9: 00-15: 00), jujubosides e ile ea eketsa haholo boroko bo feletseng le boroko bo potlakileng ba mahlo (REM), empa ha ea ka ea e-ba le phello e kholo ho boroko ba non REM (NREM).Bosiu (21:00-3:00), jujubosides e ne e eketsa boroko bo felletseng le boroko ba NREM, haholo boroko bo bobebe, empa e ne e se na phello e kholo ho robala ha REM le ho robala butle (SWS) [3].Kalafo ea Intraventricular e nang le jjuboside a e ile ea fokotsoa haholo ke Y-maze, ho qoba ka mafolofolo le litekanyo tsa maze tsa metsi a Morris β 1-42 tse susumelitsoeng ho ithuta le ho senyeha ha mohopolo ho litoeba.Intracerebroventricular injection ea Jujuboside A e fokotsehileng ea hippocampal a β 1-42 e ile ea thibela haholo mesebetsi ea acetylcholinesterase (AChE) le che, 'me ea fokotsa litaba tse ntseng li eketseha tsa malondialdehyde (MDA) hippocampus le cerebral cortex ea litoeba tse kenngoeng ka lehlakoreng le leng la β1. [4].
Teko ea lisele:ka mor'a matsatsi a 7 a setso sa in vitro, lisele li ne li ntse li pepeseha ka lihora tse 24 kapa lihora tse 72, 'me ha lia ka tsa pepeseha ka mokhoa o nang le Jujuboside A kapa diazepam kapa ka bobeli.Vector e ile ea kenngoa sehlopheng sa taolo;Sehlopha sa Diazepam se kentse 10 μ M diazepam;Jujuboside A82 μ M (hoo e ka bang 0.1g / L) le 41 μ M (hoo e ka bang 0.05 g / L) e kentsoe ho lihlopha tsa jua-h (tekanyo e phahameng ea Jujuboside A) le jua-l (tekanyo e tlase ea Jujuboside A), ka ho latellana.Kakaretso ea RNA e ne e arohane le lisele bakeng sa tlhahlobo e eketsehileng [1].
Teko ea liphoofolo:litoeba: a e entsoe ka ICV β 1-42 e bakileng ho senyeha ha kelello ho litoeba.Joale, litoeba li ile tsa kenngoa ka Jujuboside A (0.02 le 0.2 mg / kg) intraventricular (ICV) ka matsatsi a 5.Y maze, ho qoba ka matla le liteko tsa maze tsa metsi tsa Morris li entsoe ka litoeba [1].
Lebitso la Senyesemane la Jujuboside A
α-L-arabinopyranoside, (3β,16β,23R)-16,23:16,30-diepoxy-20-hydroxydammar-24-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O-[O-β-D-glucopyranosyl-(1->6)-O-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->3 )]-
(3β,16β,23R)-20-Hydroxy-16,23:16,30-diepoxydammar-24-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D -glucopyranosyl-(1->6)-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->3)]-α -L-arabinopyranoside
jujuboside C
α-L-Arabinopyranoside, (3β,16β,23R)-16,23:16,30-diepoxy-20-hydroxydammar-24-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O-[O-β-D-glucopyranosyl-(1->6)-O-[β-D-xylopyranosyl-(1->2)]- β-D-glucopyranosyl-(1->3 )]-
JujubosideA
(3β,16β,23R)-20-Hydroxy-16,23:16,30-diepoxydammar-24-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D -glucopyranosyl-(1->6)-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->3)]-α-L-arabinopyranoside
