Methylophiopogonanone A;Opogonanone A
Tšebeliso ea Methylophiopogonanone A
Methylophiopogonanone A ke flavonoid e ntšitsoeng ho Ophiopogon japonicas, e nang le litlamorao tsa antioxidant le anti-inflammatory.
Lebitso la Methylophiopogonanone A
Lebitso la Senyesemane:
(3R) -3-(1,3-benzodioxol-5-ylmethyl) -5,7-dihydroxy-6,8-dimethyl-2,3-dihydrochromen-4-one
Lebitso la Sechaena:
Ophiopogon methyl flavanone a |methyl Ophiopogon dihydrohomoisoflavone a |methyl Ophiopogon flavanone a
Ts'ebetso ea Baeloji ea Methylophiopogonanone A
Tlhaloso: methylophiopogonanone A ke flavonoid e ntšitsoeng ho Ophiopogon japonicas, e nang le
antioxidant le anti-inflammatory liphello.
Likarolo tse Amanang: tsela ea matšoao > > apoptosis > > apoptosis
lefapha la lipatlisiso > > ho ruruha / ho itšireletsa mafung
Thutong ea Vitro: methyl aspartate a (mo-a; 10 μ Mo (L / L) e fokotsehile haholo apoptosis le polelo ea Caspase-3, e eketsehile karo-karolelano ea Bcl-2 / Bax mme ha e tsosolose tlhahiso.
e ntlafalitse haholo ts'ebetso ea tsela ea PI3K / Akt / eNOS liseleng tsa H9c2 tlasa H / R, ha ts'ireletso ea mo-a e hlakotsoe ka boteng ba PI3K inhibitor wortmannin (100 nmol / L) [1].
Thutong ea Vivo: Tšireletso ea methylaspartate a (mo-a; 10mg / kg / D, PO) mosebetsing oa pelo ka mor'a kotsi ea myocardial I / R [1].
Litšupiso: [1] He F, et al.Methylophiopogonanone A e hatella ischemia/reperfusion-induced myocardial apoptosis ho litoeba ka ho kenya PI3K/Akt/eNOS tsela ea pontšo.Acta Pharmacol Sin.2016 Jun;37(6):763-71.
Lintho tsa Physicochemical of Methylophiopogonanone A
Boima: 1.4 ± 0.1 g / cm3
Ntho e Belang: 580.1 ± 50.0 ° C ho 760 mmHg
Foromo ea molek'hule: c19h18o6
Boima ba 'mele: 342.343
Sebaka sa Flash: 212.9 ± 23.6 ° C
'Misa Hantle: 342.110352
PSA:85.22000
Lethathamo: 5.16
Khatello ea Mouoane: 0.0 ± 1.7 mmHg ho 25 ° C
Index ea Refractive: 1.654
Letšoao la Senyesemane la Methylophiopogonanone A
(1,3-Benzodioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethyl-2,3-dihydro-4H-chromen-4-one
4H-1-Benzopyran-4-one, 3-(1,3-benzodioxol-5-ylmethyl) -2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-
N1002
Methylophiopogonanone A
Tšebeletso ea Yongjian
Customized Service Of Chemical Reference Materials Of Traditional Chinese Medicine
Jiangsu Yongjian Pharmaceutical Technology Co., Ltd. e ikakhetse ka setotsoana lipatlisisong tsa mantlha tsa lintho tse sebetsang tsa meriana ea setso ea Machaena ka lilemo tse fetang leshome.Ho fihlela joale, k'hamphani e entse lipatlisiso tse tebileng ka mefuta e fetang 100 ea meriana ea setso ea Machaena e sebelisoang hangata, 'me e ntšitse likete tsa likarolo tsa lik'hemik'hale.
Khamphani e na le basebetsi ba holimo ba R&D le lisebelisoa tse phethahetseng tsa tlhahlobo le tlhahlobo indastering, 'me e sebelelitse makholo a litsi tsa lipatlisiso tsa mahlale.E ka finyella litlhoko tsa bareki ka potlako le ka katleho
Karohano ea Litšila tsa Lithethefatsi, Tokisetso le Tšebeletso ea Tiiso ea Sebopeho
Litšila tsa lithethefatsi li amana haufi-ufi le boleng, polokeho le botsitso ba lithethefatsi.Tlhophiso le netefatso ea sebopeho sa litšila tsa lithethefatsi li ka re thusa ho utloisisa mekhoa ea litšila le ho fana ka motheo oa ntlafatso ea ts'ebetso ea tlhahiso.Ka hona, ho lokisetsa le ho arohana ha litšila ho bohlokoa haholo ho lipatlisiso le nts'etsopele ea lithethefatsi.
Leha ho le joalo, litaba tsa litšila ka har'a sethethefatsi li tlase, mohloli o pharaletseng, 'me sebopeho se tšoana haholo le karolo e ka sehloohong.Ke theknoloji efe e ka sebelisoang ho arola le ho hloekisa litšila tsohle tsa moriana ka bonngoe le ka potlako?Ke mekhoa efe le mekhoa e sebelisoang ho tiisa sebopeho sa litšila tsee?Bona ke bothata le phephetso eo litsi tse ngata tsa meriana li tobaneng le tsona, haholo likhoebo tsa meriana ea meriana ea limela le meriana ea patent ea China.
Ho ipapisitsoe le litlhoko tse joalo, k'hamphani e thakhotse litšebeletso tsa karohano ea litšila tsa lithethefatsi le lits'ebeletso tsa tlhoekiso.E itšetlehile ka matla a matla a nyutlelie, spectrometry ea boima le lisebelisoa tse ling le theknoloji, k'hamphani e ka tseba ka potlako sebopeho sa metsoako e arohaneng, e le ho finyella litlhoko tsa bareki.
Teko ea Liphoofolo tsa SPF
Sebaka sa kaho ea sebaka sa liteko tsa liphoofolo ke lisekoere-mithara tse 1500, ho kenyeletsoa lisekoere-mithara tse 400 tsa sebaka sa liteko sa boemo ba SPF le lisekoere-mithara tse 100 tsa laboratori ea lisele tsa P2.E etelletsoe pele ke bo-ramahlale ba China Pharmaceutical University, e theha sehlopha sa mantlha sa tekheniki se nang le palo ea batho ba khutlang.Fana ka mehlala ea liphoofolo tsa boleng bo holimo, moralo oa liteko, merero ea kakaretso le litšebeletso tse ling bakeng sa lipatlisiso tsa saense tsa biomedical, thuto le nts'etsopele ea indasteri.
Sebaka sa Khoebo
1. Ho fepa liphoofolo tse nyenyane
2. Mohlala oa mafu a liphoofolo
3. Ts'ebetso ea projeke ea koleche
4. Tlhahlobo ea Pharmacodynamic ka vivo
5. Tlhahlobo ea Pharmacokinetic
6. Tšebeletso ea liteko tsa lisele tsa tumor
Matla a Rona
1. Tsepamisa maikutlo litekong tsa sebele
2. Hantle-ntle maemo a tshebetso
3. Saena ka tieo tumellano ea lekunutu
4. Laeborari ea hau ntle le lihokelo tse mahareng
5. Sehlopha sa litsebi tsa theknoloji se tiisa boleng ba liteko
Tikoloho ea liteko ea SPF, ho fepa batho ka ho khetheha, tsoelo-pele ea liteko tsa nako ea nnete
