Neohesperidin
Tšebeliso ea Synephrine Hydrochloride
Neohesperidin ke mofuta wa motswako wa flavonoid o fumanehang haholo dimeleng tsa Cucurbitaceae mme o na le antioxidant le anti-inflammatory effects./h2>
Lebitso la Neohesperidin
Lebitso la Senyesemane: neohesperidin
Lebitso la Sechaena: neohesperidin |neohesperidin
Bioactivity ea Neohesperidin
Tlhaloso: neohesperidin ke motsoako oa flavonoid o fumanoang ho Cucurbitaceae, o nang le liphello tsa antioxidant le anti-inflammatory.
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lefapha la lipatlisiso > > ho ruruha / ho itšireletsa mafung
lihlahisoa tsa tlhaho > > flavonoids
Thuto ea In Vitro:
Hesperidin e ncha e kenya apoptosis ho mofetše oa matsoele oa motho MDA-MB-231 liseleng.Litekanyetso tsa IC50 tsa neohesperidin ho 24 le lihora tsa 48 e ne e le 47.4 ± 2.6, ka ho latellana μ M le 32.5 ± 1.8 μ M. Polelo ea p53 le Bax e ne e laoloa haholo ka lisele tse tšoaroang tsa neohesperidin, ha polelo ea Bcl-2 e ntse e theoha. e laoloang [1].Neohesperidin e bontšitse ts'ebetso ea antioxidant tekong ea DPPH e matla ea ho senya (IC50 = 22.31 μ g/ mL) [2].
Thutong ea Vivo: neohesperidin (50mg / kg) e thibetse haholo 55.0% HCl / ethanol e bakileng kotsi ea gastric.Likhotong tsa pylorus ligated, neohesperidin (50 mg / kg) e fokolitse haholo secretion ea gastric le gastric acid e hlahisoang le ho eketseha pH [1].Kalafo ea Neohesperidin e fokolitse haholo tsoekere ea mali e potlakileng, tsoekere ea mali le glycosylated serum protein (GSP) ho litoeba.E ile ea eketsa haholo mamello ea tsoekere ea molomo le kutloisiso ea insulin, le ho fokotsa ho hanyetsa insulin ho litoeba tsa lefu la tsoekere.Neohesperidin e fokolitse haholo serum triglycerides, k'holeseterole eohle, maemo a leptin le index ea sebete ho litoeba [3].
Teko ea Liphoofolo: Litoeba: Litoeba tsohle li ile tsa itima lijo lihora tse 6 pele ho tlhahlobo, ebe li feptjoa ka metsi kapa neohesperidin ka ho fepa ka likhoka.Bakeng sa OGTT le ITT, litoeba li ne li kentsoe intraperitoneally ka 2G / kg BW glucose kapa 1iu / kg BW insulin, ka ho latellana.Lisampole tsa mali li ile tsa bokelloa ho tsoa mothapong oa caudal ho lekanya maemo a tsoekere ea mali a basal (metsotso e 0) pele ho ente ea tsoekere kapa insulin.Maemo a eketsehileng a tsoekere ea mali a lekantsoe ka metsotso e 30, 60, 90 le 120 [3].
Tšupiso:[1].Lee JH, le ba bang.Tšireletso ea neohesperidin le poncirin e arohaneng le litholoana tsa Poncirus trifoliata ka lefu le ka 'nang la e-ba teng gastric.Phytother Res.2009 Dec;23(12):1748-53.
[2].Xu F, le ba bang.Neohesperidin e kenya apoptosis ea cellular letsoeleng la motho adenocarcinoma MDA-MB-231 liseleng ka ho kenya tšebetsong tsela ea pontšo ea Bcl-2/Bax-mediated.Nat Prod Commun.2012 Nov;7(11):1475-8.
[3].Jia S, le ba bang.Hypoglycemic and hypolipidemic effects of neohesperidin derived from Citrus aurantium L. in diabetic KK-A(y) litoeba.Mosebetsi oa Lijo.2015 Mar;6(3):878-86.
Lintho tsa Physicochemical of Neohesperidin
Boima: 1.7 ± 0.1 g / cm3
Ntho e Belang: 933.7 ± 65.0 ° C ho 760 mmHg
Sebaka se qhibilihang: 239-243 ºC
Foromo ea molek'hule: C28H34O15
Boima ba 'mele: 610.561
Sebaka sa Flash: 306.7 ± 27.8 ° C
'Misa Hantle: 610.189758
PSA:234.29000
LogP:2.44
Ponahalo: 0.0 ± 0.3 mmHg ho 25 ° C
Khatello ea Mouoane: 0.0 ± 0.3 mmHg ho 25 ° C
Index ea Refractive: 1.695
Maemo a polokelo: 2-8 ° C
Tlhahisoleseding e Ncha ea Tšireletso ea Hesperidin
Lisebelisoa tsa ho itšireletsa: litšiea tsa mahlo;Liatlana;mofuta oa N95 (US);mofuta oa P1 (EN143) filthara ea ho phefumoloha
Polelo ya Polokeho (Yuropa): s22-s24 / 25
Khoutu ea lipalangoang ea thepa e kotsi: nonh bakeng sa mefuta eohle ea lipalangoang
Wgk Jeremane: 3
Nomoro ea RTECS: dj2981400
Lingoliloeng tsa Neohesperidin
Tlhahlobo e bapisoang ea metabolism le transcriptal ea diploid e imenneng habeli le methapo ea eona ea diploid citrus (C. junos cv. Ziyang xiangcheng) e fana ka maikutlo a boleng ba eona bo ka bang teng bakeng sa ntlafatso ea ho hanyetsa khatello ea maikutlo.
BMC Plant Biol.15 , 89, (2015)
Hangata polyploidy e 'nile ea nkoa e thusa limela ho ikamahanya le maemo a tikoloho.Tetraploid citrus rootstocks e lebelletsoe ho ba le mamello e matla ea khatello ea maikutlo ho feta diploid.Tse ngata...
Ougan (Citrus reticulata cv. Suavissima) flavedo extract e hatella motility ea kankere ka ho kena-kenana le phetoho ea epithelial-to-mesenchymal liseleng tsa SKOV3.
Chin.Med.10 , 14, (2015)
Ougan (Citrus reticulata cv. Suavissima) flavedo extract (OFE) e bontšitse liphello tse ka 'nang tsa e-ba khahlanong le hlahala ka mekhoa e sa hlakang ea motheo.Boithuto bona bo ikemiselitse ho lekola tšebetso e ka bang teng ea anti-metastatic ...
Hesperidin, nobiletin, le tangeretin ka kakaretso li ikarabella bakeng sa matla a anti-neuroinflammatory a tangerine peel (Citri reticulatae pericarpium).
Chem ea Lijo.Toxicol.71 , 176-82, (2014)
Inhibiting microglial activation-mediated neuroinflammation e fetohile sepheo se kholisang bakeng sa nts'etsopele ea lijo tse sebetsang ho phekola mafu a neurodegenerative.Lekhapetla la tangerine (Citri reticulata ...
Senyesemane Alias Of Neohesperidin
HESPERETIN-7-NEOHESPERIDOSIDE
Hesperetin7-neohesperidoside
4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy] -2,3-dihydro-5-hydroxy-2 -(3-hydroxy-4-methoxyphenyl)-, (2S)-
(2S)-5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 2-O-(6-deoxy-α-L- mannopyranosyl) -β-D-glucopyranoside
hesperetin 7-O-neohesperoside
Neohesperdin
Neohesperdin
MFCD00017357
Hesperetin-7-O-neohesperidoside
EINECS 236-216-9
(S) -4'-Methoxy-3',5,7-trihydroxyflavanone-7-[2-O-(α-L-rhamnopyranosyl)-β-D-glucopyranoside]
4H-1-Benzopyran-4-one, 2,3-dihydro-7-((2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl) oxy) -5-hydroxy-2 -(3-hydroxy-4-methoxyphenyl)-, (S)-
Hesperetin 7-O-neohesperidoside
