Litaba

Lipatlisisong le nts'etsopele ea meriana e mecha ea Machaena, boleng ba khauta bo holimo ke meriana e mecha ea 6.1, meriana ea Machaena le litokisetso tsa motsoako oa meriana ea tlhaho tse sa kang tsa rekisoa lapeng le kantle ho naha.Litaba tse mpe ke hore likopong tse ncha tse 37 tsa meriana ea Sechaena lilemong tse 17 tsa ngoliso e ncha ea lithethefatsi, ke tse 5 feela tse amohetsoeng.Litaba tse monate ke hore tsena tse 5 kaofela ke lithethefatsi tse ncha tse 6.1.

Le hoja ho ne ho e-na le maano a ho tšehetsa tsoelo-pele ea meriana ea Sechaena ka 2017, e ileng ea fa meriana ea Sechaena mokhoa o fokolang oa ho nyoloha, e ntse e sa fetole boemo bo thata ba ntlafatso ea meriana ea Chaena.

Ho thata haholo, 'me ho na le mathata a ka boleloang...Ka mohlala, litaba tsa thepa ea meriana mehloling e fapaneng, tšimoloho e fapaneng, le linako tse fapaneng tsa kotulo, le sekhahla sa tlhahiso ea peista li fapane haholo, botsitso ba ts'ebetso bo ke ke ba tiisetsoa, ​​taolo ea boleng e ke ke ea rarolloa, 'me ketsahalo ea ho kopanya tlhahiso ke ha e le hantle. tloaelehileng.Tlhokahalo ea tokoloho ea maano.

Bothata ba lihlahisoa tsa mafura tseo u mpotsitseng tsona maobane ehlile li rarahane haholo.Nka sehlahisoa e le mohlala.Setlhare se itseng se tsoang Gansu le Sichuan se na le tšimoloho e fapaneng ho tsoa mohloling o le mong.Linako tse fapaneng tsa kotulo li maketse haholo.Lintlha tsa 'nete mabapi le lihlahisoa tsa mafura ke tsa rona.Ha ho na data ea sebele mabapi le tlhahiso e fumanehang, 'me lintlha tsena ke sephiri se ka sehloohong bakeng sa k'hamphani e' ngoe le e 'ngoe.Empa mohlomong rea tseba hore ho feto-fetoha ho hoholo.Hase feela bothata ba lisebelisoa tsa meriana, empa hape le ts'ebetso.Ho na le khatello e ngata tlhahisong ea mefuta e meholo ea lisebelisoa tsa meriana selemo le selemo.Mefuta ea rona e meholo e thibetsoe ke boholo ba tlhahiso, 'me tlhahiso e haella selemo ho pota.Ka hona, ho ke ke ha khoneha ho sebelisa vacuum e omisang mocheso o tlase kapa ho omisa ka ontong sethaleng sa lipatlisiso.Ke bethe e nang le mokelikeli oa granulation ea mohato o le mong kapa ho omisa ka spray.Ho sa tsotellehe ts'ebetso, ho tla ba le mathata a mangata tlhahisong e kholo, hobane li-polysaccharides le tanning li tla baka ho khomarela, 'me litekanyetso tse fapaneng tsa peista li tla lebisa ho putlama ha capsule.Tharollo e kotsi, kahoo Japane e lula e sebelisa li-intermediates e le lisebelisoa tse tala bakeng sa ho itokisa ka bolokolohi.China e hatisa hore lisebelisoa tsa meriana tse kopantsoeng li sebelisoa e le yuniti, 'me li-intermediate ha lia lumelloa.

Leha ho le joalo, ha e le hantle, k'hamphani e 'ngoe le e' ngoe e tla ba le bothata ba mofuta ona oa ho tsamaisa.Ha ho le thata ho laola boleng, ho hlokahala haholoanyane, ho seng joalo ho tla ba le likotsi tse nang le matšoao a mangata.Khampani e 'nile ea etsa lipatlisiso ka nako e telele,' me ha rea ​​ka ra lumela hore e shoele tlhahisong.Re ke ke ra etsa letho ka bona.Litšoaneleho tse ling tse 'maloa tsa tlhahiso ea GMP le tsona li etetse,' me boemo bo ntse bo tšoana.Lipatlisiso tse nyenyane le tsa lifofane li batla li le bonolo, empa ha ho na lisebelisoa tse ngata tsa tlhahiso ea lihlahisoa tse kholo Chaena, 'me ha li lekane,' me mathata a sa tšoaneng a tloaelehile ka mor'a ho holisoa.Ha se hore haeba k'hamphani e sa sebetse ka thata ho e rarolla, u tla fumana hore ho thata haholo ha u ka etsa moriana o mocha.Ho hlokahala melaoana ho ts'ehetsa pholiso ea maano.Re sa bue ka ho etsa lihlopha tse tharo tsa liteko tsa lifofane, tlhahiso ea rona e kholo e tsosolositsoe ka makhetlo a fetang leshome le metso e 'meli,' me ho ntse ho tla ba le mathata a mangata a tshebetso.

Bothata ba meriana ea Sechaena bo boholo hoo bo hlokang tšepo.Taba ea pele, barutehi ha ba ele hloko hobane ha ba khone ho hatisa lingoliloeng.Ea bobeli, ha ba na bokhoni ba ho etsa mesebetsi e fapaneng.Ea boraro, ha ba na chelete ea thepa.Sena se lebisa ho se lumellane lipakeng tsa lipatlisiso le boikoetliso.

Kajeno, ho lokolloa mofuta oa 2020 oa thepa e omileng ea pharmacopoeia:

1. Ho ntlafatsa bokhoni ba litekanyetso tsa TCM ho sebetsana le litaba tsa boleng, ke hore, ho rarolla bothata boo litekanyetso tse itseng tsa TCM li tobanang le bothata ba "ho se sebelise" ts'ebetsong e rarahaneng le e fetohang ea taolo.Ho fihlela litekanyetso tse behiloeng tse ka rarollang mathata a boleng ba meriana ea setso ea Machaena ka nepo, hoa hlokahala ho theha monahano o mocha, ho qala ka pono e felletseng, le ho amohela mekhoa ea botekgeniki joalo ka menoana ea meriana ea setso ea China e ka lekola boleng ba meriana ea setso ea Sechaena. , e le hore mathata a boleng a ka fumanoa le ho rarolloa ka nako.

2. Ntlafatsa ka botlalo bokhoni ba tlhahlobo ea polokeho le maemo a meriana ea setso ea Machaena.Meriana ea litlama ea Sechaena le likotoana tsa li-decoction li na le litšepe tse boima le likarolo tse kotsi, masala a chefo e bolaeang likokoanyana, li-mycotoxins le liteko tse ling tsa lintho tse kotsi le litekanyetso tsa bona tsa moeli, 'me butle-butle li khothalletsa ho thehoa ha meriana ea patent ea China.Litekanyetso tsa liteko tsa lintho tse kotsi;tsoela pele ho etsa lipatlisiso ka mekhoa ea ho etsa qeto le ho fokotsa litekanyetso tsa masala a chefo e bolaeang likokoanyana, lihomone tsa limela, li-mycotoxins le lintho tse ling tse kotsi tse tsoang kantle ho naha.

3. Tsepamisa maikutlo ho ntlafatsa bokhoni ba ho lemoha le boemo bo ka khethollang katleho ea meriana ea setso ea Machaena, ho khothalletsa tšebeliso ea menoana le 'mapa oa sebopeho, boikemisetso ba likarolo tse ngata le mahlale a mang a ho lemoha bakeng sa taolo e akaretsang ea likarolo tsa meriana ea setso ea Machaena ka Sechaena sa setso. litekanyetso tsa meriana, le ho tsoela pele ho ntlafatsa lintlha tsa menoana le thekenoloji ea ho lemoha limmapa le tlhahlobo Lipatlisiso tsa Methodological;matlafatsa lipatlisiso le pokello ea lintlha tse qotsitsoeng tsa taolo ea meriana ea setso ea Machaena le lisebelisoa tsa litšupiso, le ho matlafatsa lipatlisiso tsa mekhoa e mengata ea tlhahlobo ea likarolo tse ngata tse sebelisang lintho tse ling tsa litšupiso e le taolo, ho kenyeletsoa litaba tse nang le likarolo tse ngata tse nang le maemo a kahare kapa litekanyetso le taolo ea boits'oaro. li-extracts e le li-control Ho rarolla mathata a kang khaello kapa ho se tsitse ha thepa ea litšupiso, ho fokotsa litšenyehelo tsa tlhahlobo, le ho fana ka tiisetso ea ntlafatso le ts'ebetsong ea litekanyetso;bakeng sa theko e boima le e bonolo ho kopanya meriana ea litlama tsa Machaena le likotoana tsa decoction, tsoela pele ho etsa lipatlisiso tsa boitsebiso ba limolek'hule tsa DNA tse thehiloeng ho liphatsa tsa lefutso ho rarolla mathata a hona joale Bothata ba morphology le boitsebiso ba lik'hemik'hale bo thata ho bo rarolla;tsepamisa maikutlo lipatlisisong tsa mekhoa ea phello ea likokoana-hloko e ka bonahatsang ka ho toba katleho ea bongaka ea meriana ea setso ea Machaena, le ho hlahloba ho sebetsa ha mekhoa ea ho lemoha liketsahalo tsa likokoana-hloko tlhahlobong ea boleng ba meriana ea setso ea Machaena.

4. Emisa le ho ntlafatsa mekhoa ea tlhahlobo, lits'ebetso, meeli, likahlolo tsa sephetho le litlhaloso tsa moralo le mantsoe le lipehelo tse ling;teka-tekanya le ho hokahanya botsitso bo lekanyelitsoeng ba letoto le tšoanang la taolo ea boleng ba sehlahisoa, mekhoa ea tlhahlobo, matšoao le meeli.Ntlafatsa le ho kopanya mantsoe a meriana ea setso ea Sechaena, ho totobatsa litšobotsi tsa phapang ea lefu lena, ho tiisa polelo ea mesebetsi le matšoao, ho hlophisoa ha matšoao a mantlha le a bobeli, le ho rarolla mathata ka botlalo joalo ka litlhaloso tse sa nepahalang, ho se lumellane, le matšoao a pharaletseng.

5. Ho buella ka matla maemo a botala le maemo a moruo, ho khothalletsa tšebeliso ea chefo e tlaase, tšilafalo e fokolang, ho baballa mehloli, ho sireletsa tikoloho, mekhoa e bonolo le e sebetsang ea ho lemoha, le ho emisa ka ho feletseng tšebeliso ea lintho tse chefo tse kang benzene le ho li nkela kaofela.

Litaba tse monate ke hore ts'ebeliso ea mahlale a macha e tla salla morao, empa e ke ke ea ba sieo.Theha ka botlalo moeli oa masala a chefo e bolaeang likokoanyana le mesaletsa ea tšepe e boima, ICP-MS e nkile sebaka ka botlalo sa atomic spectrophotometry, 'me GC e tumme ka botlalo;ho khothaletsa mokhoa o tloaelehileng oa ka hare, tlhahlobo e le 'ngoe le tlhahlobo e ngata, European Pharmacopoeia, American Pharmacopoeia meriana ea tlhaho e se e le nako e telele e le mokhoa o tloaelehileng oa ka hare, Chinese Pharmacopoeia Ho na le mekhoa e seng mekae feela ea mekhoa e tloaelehileng ea ka hare, ho ka boleloa hore ha e le hantle ha ho na;ho thehoa ha menoana ea menoana, e bontšang ho ba le botlalo, ntle le lipilisi tsa Tasly tsa Danshen tse rothang le mefuta e meng e meholo ea lik'hamphani tse tsebahalang, ha e le hantle ha ho letho le ka etsoang hona joale;buisana ka mekhoa ea ho lemoha liketsahalo tsa baeloji Ho sebelisoa ke theknoloji e 'ngoe e tla salla morao ka lilemo tse 20.

Qetellong, e re ke bue ka pono ea ka e lumellanang.Bothata ke eng ka meriana ea Machaena?Mmaraka o moholo o hlahisitse thekenoloji e ntle ka ho fetisisa, joalo ka ho phahama ha theknoloji ea likhomphutha ea China, ho phahama ha theknoloji ea China ea likhokahano, le ho phahama ha bohlale ba maiketsetso ba China.Bothata boo re buileng ka bona kajeno ke minutiae feela, 'me bo teng' marakeng.Bothata ba meriana ea Sechaena ke hore ha e khone ho etsa chelete e ngata.Mefuta e meholo e ke ke ea lula limmarakeng tsa kantle ho naha joalo ka meriana ea bophirima le lithethefatsi tsa lik'hemik'hale.Palo ea thekiso ke mashome a libilione.Hajoale, meriana ea Machaena e limilione tse makholo ke mefuta e meholo.Etsa chelete e lekaneng, kapa u lumelle bo-ramatsete hore ba bone tšepo ea ho etsa chelete e ngata, 'me lintho tse ling li tla rarolloa ka tlhaho.