Ophiopogonin D Cas No.945619-74-9
Ophiopogon Saponin D Lebitso
Lebitso la Senyesemane:(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)] -6-deoxy-β-D-galactopyranoside
Bioactivity ea Ophiopogon Japonicus Saponin D
Tlhaloso:Ophiopogon D ke C29 steroidal glycoside ea tlhaho e sa tloaelehang e arohaneng le tuber ea Ophiopogon japonicus.Ophiopogonin D ke CYP2J3 inducer e eketsang CYP2J2 / eets le PPAR ka liseleng tsa motho umbilical vein endothelial cell (HUVECs) α Polelo ea Ang II e thibetse haholo Ang II e entseng hore NF- κ B nyutlelie translocation, I κ B α Down regulation, intracellular Ca2 + ho jara le ho kenya tšebetsong li-cytokine tsa proinflammatory.Ophiopogonin D e 'nile ea sebelisoa ho phekola ho ruruha le mafu a pelo le methapo ka lilemo tse likete.
Mekhahlelo e Amanang
Tsela ya matshwao > > dipalangwang tsa transmembrane > > kanale ya calcium
Sebaka sa lipatlisiso > > lefu la pelo
Tsela ea lipontšo>> potoloho ea lisele / tšenyo ea DNA>> PPAR
Sebaka sa lipatlisiso>> ho ruruha / ho itšireletsa mafung
Sepheo
PPARA
NF-κB
Ca2+
Litokomane tsa Litšupiso:[1].Wang L, le ba bang.Homo-aro-cholestane, furostane le spirostane saponins tse tsoang ho li-tubers tsa Ophiopogonjaponicus.Phytochemistry.2017 Apr;136:125-132.
[2].Huang X, et al.Ophiopogonin D le EETs li matlafatsa likarabo tsa Ang II tse bakoang ke ho ruruha ka ho kenya tšebetsong PPARα ho HUVECs.Biochem Biophys Res Commun.2017 Aug 19; 490 (2): 123-133.
Letšoao la Senyesemane la Ophiopogon saponin D
(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)] -6-deoxy-β-D-galactopyranoside β-D-Galactopyranoside, (1β,3β,25R) -3-hydroxyspirost-5-en-1-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O-[β-D-xylopyranosyl-(1->3)]-6-deoxy-
(2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-5-hydroxy-2-(((4R,5'R,6R,6aR,6bS,8aS) ,8bR,9S,10R,11aS,12aS,12bS)-4-hydroxy-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a, 6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2 '-pyran] -6-yl) oxy) -6-methyl-4-(((2S,3R,4S,5R) -3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydro- 2H-pyran-3-yl)oxy) -6-methyltetrahydro-2H-pyran-3,4,5-triol
Ophiopogonin D
Deacetylophiopogonin C
