Ophiopogonin D Cas No.945619-74-9
Ophiopogon Saponin D Ngaran
Ngaran Inggris:(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)] -6-deoksi-β-D-galaktopiranosida
Bioaktivitas Ophiopogon Japonicus Saponin D
Katerangan:Ophiopogon D mangrupikeun glikosida stéroid C29 alami anu diisolasi tina umbi Ophiopogon japonicus.Ophiopogonin D mangrupakeun inducer CYP2J3 nu naek CYP2J2 / eets na PPAR dina sél endothelial urat umbilical manusa (HUVECs) α The éksprési Ang II nyata ngahambat Ang II ngainduksi NF- κ B translocation nuklir, I κ B α Down régulasi, intrasélular Ca2 + overload sareng aktivasina sitokin proinflamasi.Ophiopogonin D parantos dianggo pikeun ngubaran peradangan sareng panyakit kardiovaskular salami rébuan taun.
Kategori relevan
Jalur sinyal > > angkutan transmembran > > saluran kalsium
Widang panalungtikan > > panyakit jantung
Jalur sinyal > > siklus sél / karuksakan DNA > > PPAR
Bidang panalungtikan > > radang/kekebalan
Sasaran
PPARα
NF-kB
Ca2+
Dokumén Rujukan:[1].Wang L, dkk.Homo-aro-cholestane, furostane sareng spirostane saponin tina umbi Ophiopogonjaponicus.Fitokimia.2017 Apr;136:125-132.
[2].Huang X, dkk.Ophiopogonin D na EETs ameliorate réspon radang Ang II-ngainduksi via ngaktipkeun PPARα dina HUVECs.Biochem Biophys Res Commun.2017 Agustus 19;490 (2): 123-133.
Alias Inggris tina Ophiopogon saponin D
(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)] -6-deoxy-β-D-galactopyranoside β-D-Galactopyranoside, (1β,3β,25R)-3-hydroxyspirost-5-en-1-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O-[β-D-xylopyranosyl-(1->3)]-6-déoxy-
(2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-5-hidroksi-2-((4R,5'R,6R,6aR,6bS,8aS) ,8bR,9S,10R,11aS,12aS,12bS)-4-hidroksi-5',6a,8a,9-tétramétil-1,3,3',4,4',5,5',6,6a, 6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2 '-pyran]-6-yl)oxy)-6-methyl-4-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydro- 2H-pyran-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol
Ophiopogonin D
Deacetylophiopogonin C
