Orientin
Aplikasi tina Orientin
Orientin mangrupikeun flavonoid bioaktif alami anu ngagaduhan rupa-rupa ciri biologis, kalebet anti-radang, antioksidan, anti-tumor, panyalindungan jantung sareng saterasna.Orientin mangrupikeun agén neuroprotective anu ngajangjikeun, anu cocog pikeun pengobatan nyeri neuropathic.
Bioaktivitas Orientin
Katerangan:orientin mangrupikeun flavonoid bioaktif anu alami sareng rupa-rupa ciri biologis, kalebet anti-radang, antioksidan, anti-tumor, panyalindungan jantung sareng saterasna.Orientin mangrupikeun agén neuroprotective anu ngajangjikeun, anu cocog pikeun pengobatan nyeri neuropathic.
Kategori nu patali:widang panalungtikan > > kanker
Jalur sinyal > > lain > > lain
Bidang panalungtikan > > panyakit saraf
Referen:[1].Dhakal H, et al.Balukar inhibitory of orientin dina peradangan alérgi dimédiasi sél tihang.Rep. Pharmacol 2020 Jan 24.
[2].Guo D, et al.Orientin sareng nyeri neuropathic dina beurit sareng ligasi saraf tulang tonggong.61 Int Immunopharmacol.2018 Méi;58:72-79.
Sipat fisikokimia Orientin
Kapadetan: 1,8 ± 0,1 g / cm3
Titik didih: 816,1 ± 65,0 ° C dina 760 mmHg
Titik lebur: 260-285ºC
Rumus molekul: C21H20O11
Beurat molekular: 448,377
Titik Nyala: 289,1 ± 27,8 ° C
Massa akurat: 448.100555
PSA: 201.28000
LogP: 1.58
Penampilan: bubuk konéng
Tekanan Uap: 0,0 ± 3,1 mmHg dina 25 ° C
Indéks réfraktif: 1.767
Kalarutan cai: 1 M
NaOH: larut 1mg / ml, jernih, oranyeu konéng
Inpormasi kaamanan Digitalis
Pernyataan Kasalametan (Éropa): 24/25
Kode angkutan barang bahaya: nonh pikeun sadaya modus angkutanRTECS号:DJ3009300
Tinjauan literatur ngeunaan Orientin
Beda tina pasangan isomer C-glycosylflavone orientin/isoorientin jeung vitexin/isovitexin ngagunakeun HPLC-MS ukuran massa pasti na in-sumber CID.
Phytochem.Anal.16(5), 295-301, (2005)
HPLC-MS ngagunakeun collision induced disociation (CID) geus dipaké pikeun idéntifikasi C-glycosylflavone isomer pairs orientin/isoorientin jeung vitexin/isovitexin.HPLC-CID/MS nganalisa produk..
Balukar antihypertensive sareng cardioprotective buah Lagenaria siceraria dina NG-nitro-L-arginine métil éster (L-NAME) ngainduksi beurit hipertensi.
Pharm.Biol.50(11), 1428-35, (2012)
Lagenaria siceraria (Molina) Standl.(Cucurbitacae) (LS) parantos dilaporkeun gaduh kagiatan cardioprotective, antihyperlipidemic, sareng diuretik.
Ngembangkeun sareng validasi metode HPTLC pikeun kuantitas simultan isoorientin, isovitexin, orientin, sareng vitexin dina flavonoid daun awi.
J. AOAC Int.93(5), 1376-83, (2010)
Métode HPTLC basajan geus dikembangkeun pikeun determinasi simultaneous isoorientin, isovitexin, orientin, jeung vitexin, duanana murni sarta dina sampel komérsial flavonoid daun awi.Flavon anu...
Alias Inggris tina Orientin
(1S) -1,5-Anhidro-1-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-8-yl]-D-glucitol
2-(3,4-Dihydroxyphényl)-5,7-dihydroxy-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxyméthyl)tétrahydro-2H-pyran- 2-yl]-4H-chromén-4-hiji
Orientin 8-C-β-D-glucopyranoside
3', 4', 5,7-tetrahydroxyflavone-8-C-glucoside
2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran- 2-yl]-4H-chromen-4-on
Luteolin-8-C-glukosida
3',4',5,7-tetrahydroxyflavone 8-glukosida
4H-1-Benzopyran-4-hiji, 2-(3,4-dihydroxyphenyl)-8-β-D-glucopyranosyl-5,7-dihydroxy-
D-Glucitol, 1,5-anhidro-1-C-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-1-benzopyran-8-yl]-, (1S) -
Orientin
lutexin
2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran- 2-yl]-4H-chromen-4-hiji
2-(3,4-Dihydroxyphenyl)-8-bD-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one
