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Application of Methylophiopogonanone B

Methylophiopogonone B, high isodihydroflavone, extracted from the root of Ophiopogon japonicus, has high antioxidant capacity. Methylophiopogonone B increases GTP Rho and acts through Rho signaling pathway. Methylophiopogonone B induces cell morphological changes, including dendritic contraction and stress fiber formation, through actin cytoskeleton reorganization.

Name Of Methylophiopogonanone B

English Name:
(3R)-5,7-Dihydroxy-3-(4-methoxybenzyl)-6,8-dimethyl-2,3-dihydro-4 H-chromen-4-one

 Biological activity of Methylophiopogonanone B

Description: methylophiopogonone B, high isodihydroflavone, extracted from the root of Ophiopogon japonicus, has high antioxidant capacity. Methylophiopogonone B increases GTP Rho and acts through Rho signaling pathway. Methylophiopogonone B induces cell morphological changes, including dendritic contraction and stress fiber formation, through actin cytoskeleton reorganization.

Related Categories: research field > > other

signaling pathway > > G protein coupled receptor /

G protein > > RAS

References: [1] Wang Y, et al. Homoisoflavonoids and the Antioxidant

Activity of Ophiopogon japonicus Root.

Ito Y, et al. A novel agent, methylophiopogonanone B,

promotes Rho activation and tubulin depolymerization. Mol Cell Biochem. 2007 Mar; 297(1-2):121-9. Epub 2006 Oct 7.

Physicochemical properties of Methylophiopogonanone B

Density: 1.285

Boiling Point: 554.5 ± 49.0 ° C at 760 mmHg

Molecular Formula: C19H20O5

Molecular weight: 328.359

Flash point: 201.5 ± 23.3 ° C

Exact mass: 328.131073

PSA：75.99000

LogP：5.22

Steam pressure: 0.0 ± 1.6 mmHg at 25 ° C

Refractive index: 1.617 

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