Ophiopogonin D Cas No.945619-74-9
Jina la Ophiopogon Saponin D
Jina la Kiingereza:(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)] -6-deoxy-β-D-galactopyranoside
Shughuli ya kibayolojia ya Ophiopogon Japonicus Saponin D
Maelezo:Ophiopogon D ni nadra asilia C29 steroidal glycoside iliyotengwa na kiazi cha Ophiopogon japonicus.Ophiopogonin D ni kichochezi cha CYP2J3 ambacho huongeza CYP2J2 / eets na PPAR katika seli za mwisho za mshipa wa umbilical (HUVECs) α Usemi wa Ang II ulizuia kwa kiasi kikubwa Ang II iliyosababisha NF- κ B uhamishaji wa nyuklia, I κ B α Udhibiti wa chini, Ca2 ya ndani ya seli. overload na uanzishaji wa cytokines za uchochezi.Ophiopogonin D imekuwa ikitumika kutibu uvimbe na magonjwa ya moyo na mishipa kwa maelfu ya miaka.
Kategoria Husika
Njia ya kuashiria > > usafiri wa transmembrane > > chaneli ya kalsiamu
Sehemu ya utafiti > magonjwa ya moyo na mishipa
Njia ya kuashiria > > mzunguko wa seli / uharibifu wa DNA > > PPAR
Utafiti uwanja > > kuvimba / kinga
Lengo
PPARA
NF-kB
Ca2+
Nyaraka za Marejeleo:[1].Wang L, na wengine.Homo-aro-cholestane, furostane na saponini ya spirostane kutoka kwenye mizizi ya Ophiopogonjaponicus.Phytochemistry.2017 Apr;136:125-132.
[2].Huang X, na wenzake.Ophiopogonin D na EETs huboresha majibu ya uchochezi yanayosababishwa na Ang II kupitia kuwezesha PPARα katika HUVECs.Biochem Biophys Res Commun.2017 Aug 19;490(2):123-133.
Lakabu la Kiingereza la Ophiopogon saponin D
(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)] -6-deoxy-β-D-galactopyranoside β-D-Galactopyranoside, (1β,3β,25R)-3-hydroxyspirost-5-en-1-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O-[β-D-xylopyranosyl-(1->3)]-6-deoksi-
(2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-5-hydroxy-2-(((4R,5'R,6R,6aR,6bS,8aS) ,8bR,9S,10R,11aS,12aS,12bS)-4-hydroxy-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a, 6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2 '-pyran]-6-yl)oksi)-6-methyl-4-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydro- 2H-pyran-3-yl)oksi)-6-methyltetrahydro-2H-pyran-3,4,5-triol
Ophiopogonin D
Deacetylophiopogonin C
