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Top Quality Cas No.480-20-6 - Jujuboside A CAS No. 55466-04-1 – Yongjian

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Top Quality Cas No.480-20-6 - Jujuboside A CAS No. 55466-04-1 – Yongjian Detail:

Essential Information

Chinese alias: jujube kernel saponin A, jujube kernel saponin A; Jujube kernel saponin A (standard)

English name: Jujuboside A

Plant source: it comes from the seeds of wild jujube, also known as jujube kernel and wild jujube core

Molecular formula: C58H94O26

Molecular weight: 1207.35

CAS No. 55466-04-1

Bioactivity of Jujuboside A

Target: GABA receptor, mTOR, PI3K, Akt [1] [2]

In vitro study: low dose 41 μ Jujuboside A of M (about 0.05 g / L) induced GABA (a) receptors during 24 and 72 h treatment α 1, α 5, β 2 subunit mRNA increased significantly. High dose 82 μ M (about 0.1 g / L) Jujuboside A significantly increased GABA (a) receptors at 24 h α 1, α 5 subunit mRNA levels and decreased β 2 subunit mRNA level and decreased GABA (a) receptor subunit α 1, β 2 mRNA expression was treated at 72 h [1]. Jujuboside A pretreatment can reverse the decrease of cell viability and better induce ISO induced H9c2 cell injury. Jujuboside A can accelerate the phosphorylation of PI3K, Akt and mTOR. Jujuboside A can significantly reduce the proportion of microtubule associated protein LC3-II / I in H9c2 cells [2]

In vivo study: during the day (9:00-15:00), jujubosides significantly increased total sleep and rapid eye movement (REM) sleep, but had no significant effect on non REM (NREM) sleep. At night (21:00-3:00), jujubosides significantly increased total sleep and NREM sleep, especially mild sleep, but had no significant effect on REM sleep and slow wave sleep (SWS) [3]. Intraventricular treatment with jjuboside a was significantly alleviated by a through Y-maze, active avoidance and Morris water maze measurements β 1-42 induced learning and memory impairment in mice. Intracerebroventricular injection of Jujuboside A decreased hippocampal a β 1-42 levels significantly inhibited the activities of acetylcholinesterase (AChE) and no, and decreased the increased content of malondialdehyde (MDA) in hippocampus and cerebral cortex of mice injected into lateral ventricle β 1-42[4]。

Cell experiment: after 7 days of culture in vitro, the cells were continuously exposed for 24 hours or 72 hours, and were not exposed to the medium containing Jujuboside A or diazepam or both. Vector was added to the control group; Diazepam group added 10 μ M diazepam; Jujuboside A82 μ M (about 0.1g / L) and 41 μ M (about 0.05 g / L) was added to jua-h (high dose Jujuboside A) and jua-l (low dose Jujuboside A) groups, respectively. Total RNA was isolated from cells for further analysis [1].

Animal experiment: mice: a was injected through ICV β 1-42 induced cognitive impairment in mice. Then, mice were injected with Jujuboside A (0.02 and 0.2 mg / kg) intraventricular (ICV) for 5 days. Y maze, active avoidance and Morris water maze tests were performed on mice [1].

English Alias of Jujuboside A

α-L-arabinopyranoside, (3β,16β,23R)-16,23:16,30-diepoxy-20-hydroxydammar-24-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1->2)-O-[O-β-D-glucopyranosyl-(1->6)-O-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->3)]-

(3β,16β,23R)-20-Hydroxy-16,23:16,30-diepoxydammar-24-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-glucopyranosyl-(1->6)-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->3)]-α -L-arabinopyranoside

jujuboside C

α-L-Arabinopyranoside, (3β,16β,23R)-16,23:16,30-diepoxy-20-hydroxydammar-24-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1->2)-O-[O-β-D-glucopyranosyl-(1->6)-O-[β-D-xylopyranosyl-(1->2)]- β-D-glucopyranosyl-(1->3)]-

JujubosideA

(3β,16β,23R)-20-Hydroxy-16,23:16,30-diepoxydammar-24-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-glucopyranosyl-(1->6)-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->3)]-α-L-arabinopyranoside


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Top Quality Cas No.480-20-6 - Jujuboside A CAS No. 55466-04-1 –  Yongjian detail pictures

Top Quality Cas No.480-20-6 - Jujuboside A CAS No. 55466-04-1 –  Yongjian detail pictures


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We emphasize advancement and introduce new products and solutions into the market each year for Top Quality Cas No.480-20-6 - Jujuboside A CAS No. 55466-04-1 – Yongjian , The product will supply to all over the world, such as: Indonesia, Rwanda, Malaysia, Good quality and reasonable price have brought us stable customers and high reputation. Providing 'Quality Products, Excellent Service, Competitive Prices and Prompt Delivery', we are now looking forward to even greater cooperation with overseas customers based on mutual benefits. We will work whole-heartedly to improve our products and services. We also promise to work jointly with business partners to elevate our cooperation to a higher level and share success together. Warmly welcome you to visit our factory sincerely.
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    5 Stars By Carey from Malaysia - 2018.02.21 12:14
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