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Application Of Lithospermic Acid

Lithospermic acid ((+) – lithospermic acid) is a plant derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza. It has antioxidant and hepatoprotective activities against CCl4 induced acute and in vitro liver injury.

Name of lithospermic acid

Chinese Name：Purple oxalic acid
English Name：

(2S,3S)-4-[(E)-3-[(1R)-1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy]-3-oxoprop-1-enyl]-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-3-carboxylic acid

Biological Activity Of Lithospermic Acid

Description: lithospermic acid ((+) – lithospermic acid) is a plant derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza. It has antioxidant and hepatoprotective activities against CCl4 induced acute and in vitro liver injury.

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Reference ：[1]. Chan KW, et al. Anti-oxidative and hepatoprotective effects of lithospermic acid against carbon tetrachloride-induced liver oxidative damage in vitro and in vivo. Oncol Rep. 2015 Aug;34(2):673-80.

Physicochemical Properties Of Lithospermic Acid

Density: 1.6 ± 0.1 g / cm3

Boiling point: 862.6 ± 65.0 ° C at 760 mmHg

Molecular formula: C27H22O12

Molecular weight: 538.456

Flash point: 291.3 ± 27.8 ° C

Exact mass: 538.111145

PSA：211.28000

LogP：1.45

Steam Pressure: 0.0 ± 0.3 mmHg at 25 ° C

Refractive Index: 1.745

English Alias of Lithospermic Acid

4-{(E)-2-[1-Carboxy-2-(3,4-dihydroxy-phenyl)-ethoxycarbonyl]-vinyl}-2-(3,4-dihydroxy-phenyl)-7-hydroxy-2,3-dihydro-benzofuran-3-carboxylic acid

5-{(1E)-3-[1-Carboxy-2-(3,4-dihydroxyphenyl)ethoxy]-3-oxo-1-propen-1-yl}-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-3-carboxylic acid

(2S,3S)-4-{(1E)-3-[(1R)-1-Carboxy-2-(3,4-dihydroxyphenyl)ethoxy]-3-oxo-1-propen-1-yl}-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-3-carboxylic acid

3-Benzofurancarboxylic acid, 4-[(1E)-3-[(1R)-1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy]-3-oxo-1-propen-1-yl]-2-(3,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-, (2S,3S)-

Jiangsu Yongjian Pharmaceutical Technology Co., Ltd

Jiangsu Yongjian Pharmaceutical Technology Co., Ltd., established in March 2012, is a high-tech enterprise integrating R & D, production and sales. It is mainly engaged in the production, customization and production process development of active components of natural products, traditional Chinese medicine reference materials and drug impurities. The company is located in China Pharmaceutical City, Taizhou City, Jiangsu Province, including a 5000 square meter production base and a 2000 square meter R & D base. It mainly serves major scientific research institutes, universities and decoction piece production enterprises across the country.

So far, we have developed more than 1500 kinds of natural compound reagents, and compared and calibrated more than 300 kinds of reference materials, which can fully meet the daily inspection needs of major scientific research institutes, university laboratories and decoction pieces production enterprises.
Based on the principle of good faith, the company hopes to sincerely cooperate with our customers. Our aim is to serve the modernization of traditional Chinese medicine.

Advantageous Business Scope Of The Company

1. R & D, production and sales of chemical reference materials of traditional Chinese medicine;

2. Customized traditional Chinese medicine monomer compounds according to customer characteristics

3. Research on quality standard and process development of traditional Chinese medicine (plant) extract

4. Technology cooperation, transfer and new drug research and development.