Iimveliso

Inkcazo:i-monoammonium glycyrrhizinate hydrate inemisebenzi ye-pharmacological efana ne-anti-inflammatory, anti-allergic, anti gastric ulcer kunye ne-anti hepatitis.

Iindidi ezinxulumeneyo:
indlela yomqondiso > > enye > > enye
Inkalo yophando > > ukudumba / ukunganyangeki

KwiSifundo seVivo:ukwanda kwemiphunga w / D ubunzima ratio kwancitshiswa kakhulu ngokulawulwa iidosi eziphezulu naphakathi mag (10 kunye 30 mg / kg).Unyango lwangaphambili nge-mag (10 kunye ne-30 mg / kg) yanciphisa ngokufanelekileyo i-TNF- α kunye ne-IL-1 β Generation ye.I-Mag (10,30 mg / kg) yanciphisa kakhulu i-NF xa kuthelekiswa ne-LPS- κ Bp65 iprotein expression.Ngokwahlukileyo, i-LPS iyancipha kakhulu ndithelekisa neqela lokulawula κ B- α Iprotheyini ibonakaliso, ngelixa i-mag (10 kunye ne-30 mg / kg) yanda kakhulu I κ B- α Ukuchazwa [1].Xa kuthelekiswa namaqela e-RIF kunye ne-INH, i-dose ephantsi kunye ne-high-dose ye-MAG yonyango yanciphisa kakhulu i-ast, i-alt, i-TBIL kunye namanqanaba e-TBA kwi-14 kunye neentsuku ze-21, ebonisa umphumo wokukhusela we-MAG kwi-RIF - kunye ne-INH -.Ukukhuthaza ukulimala kwesibindi.Iqela lonyango lwe-MAG landise i-GSH yesibindi kwi-7, i-14 kunye neentsuku ze-21, kwaye yanciphisa kakhulu inqanaba le-MDA kwi-14 kunye neentsuku ze-21 kwi-RIF kunye ne-INH ephathwayo, ebonisa umphumo wokukhusela we-MAG kwi-RIF - kunye.I-INH yenza ukwenzakala kwesibindi [2].

Imifuniselo yezilwanyana:iigundane [1] kwesi sifundo, i-BALB / c iigundane (indoda, iiveki ze-6-8 ubudala, i-20-25g) zisetyenzisiwe.Iigundane zahlulwe ngokungaqhelekanga zibe ngamaqela e-5: iqela lokulawula, iqela le-LPS kunye ne-LPS + monoammonium glycyrrhizinate (Mag: 3,10 kunye ne-30mg / kg).Iqela ngalinye liqulathe iimpuku ezisi-8.Iimpuku zaye zafakwa i-anesthetized ngenaliti ye-intraperitoneal ye-pentobarbital sodium (50 mg / kg).Iigundane zatofwa nge-intraperitoneally nge-mag (3, 10 kunye ne-30 mg / kg) ngaphambi kokuba zenze ukwenzakala okukhulu kwemiphunga.Emva kweyure ye-1, i-LPS (5 mg / kg) yafakwa kwi-intracheal ukuze yenze ukwenzakala okukhulu kwemiphunga.Iimpuku eziqhelekileyo zanikwa i-PBS [1].Iimpuku [2] zasebenzisa iimpuku zeWistar (180-220g).Iigundane zahlulwe ngokungaqhelekanga zibe ngamaqela e-4: iqela lokulawula, i-RIF kunye neqela le-INH, iqela le-MAG eliphantsi kwe-dose kunye neqela le-MAG ephezulu, kunye ne-15 yeegundane kwiqela ngalinye.Iimpuku kumaqela e-RIF kunye ne-INH zinikwe i-RIF (60mg / kg) kunye ne-INH (60mg / kg) nge-gavage kanye ngemini;Iigundane kwiqela le-MAG zaphathwa ngaphambili nge-MAG kwi-dose ye-45 okanye i-90 mg / kg, kunye ne-RIF (60 mg / kg) kunye ne-INH (60 mg / kg) zanikwa iiyure ze-3 emva kokulawulwa kwe-MAG;Iigundane kwiqela lolawulo ziphathwe nge-saline eqhelekileyo.Ukuze uvavanye umphumo oguqukayo weyeza, iigundane kwiqela ngalinye zabulawa 7, 14 kunye ne-21 iintsuku emva kokulawulwa [2].

Isalathiso:1].Huang X, et al.Iimpembelelo ezichasene nokudumba kweMonoammonium Glycyrrhizinate kwiLipopolysaccharide-Induced Acute Lung Injury kwiiMice ngokuLawulwa kweNyukliya ye-Nuclear-Kappa B yeNdlela yokuSawula.I-Evid Based Complement Alternat Med.2015;2015:272474.
[2].UZhou L, kunye nabanye.I-Monoammonium glycyrrhizinate ikhusela i-rifampicin- kunye ne-isoniazid-induced hepatotoxicity ngokulawula intetho yesithuthi uMrp2, Ntcp, kunye ne-Oatp1a4 esibindini.Pharm Biol.2016;54(6):931-7.