Cycloastragenol CAS No. 78574-94-4
Ukucaciswa kweMveliso
[igama]:utywala cycloastragalus
[isikweyeli]:i-triterpenoid cyclic flavonol
[Igama lesiNgesi]:cycloastragenol
[ifomula yemolekyuli]:C30H50O5
[ubunzima bemolekyuli]:490.71
[Inombolo yeCAS]:78574-94-4
[indlela yokubona]:HPLC ≥ 98%
[Inkcazo]:20mg 50mg 100mg 500mg 1g (inokupakishwa ngokweemfuno zomthengi)
[iipropati]:le mveliso ayinambala i-acicular crystal
[ukusebenza kunye nokusetyenziswa]:Le mveliso isetyenziselwa ukumisela umxholo, ukuchongwa, umfuniselo wekhemesti, ukuhlolwa komsebenzi kunye nolunye uphando lophando lwezenzululwazi.Njengokulawulwa kweeseli, uvavanyo lwe-intragastric, ukuhlolwa komgangatho wangaphakathi wefektri yamayeza, njl.njl Umthombo: Astragalus membranaceus (Fisch.) Bge.Isicatshulwa sengcambu eyomileyo
Indlela yokugcina
I-2-8 ° C, itywinwe ekukhanyeni kwaye igcinwe kwiqondo lokushisa eliphantsi.
Phawula
Le mveliso kufuneka igcinwe kwiqondo lokushisa eliphantsi.Ukuba ibonakaliswe emoyeni ixesha elide, umxholo uya kuncitshiswa.
Iimeko zeChromatographic} ikholamu yechromatographic: Zorbax rx-c18 (4.6mm) × 150mm)，5 μ m; Isigaba seselula: amanzi e-acetonitrile (30:70);Izinga lokuhamba: 1.0ml / min, ubushushu bekholamu: 35 ℃, iiparamitha ze-ELSD: iqondo lokushisa ityhubhu ye-drift: 105 ℃, izinga lokuhamba kwe-nitrogen: 2.70ml / min.
Iimpawu zePhysicochemical: Ubuninzi 1.20
I-Bioactivity ye-cycloastragenol
I-Cycloastragalol yi-triterpene saponin ikhompawundi, eyi-Astragalus membranaceus (Fisch.) I-hydrolyzate yesithako esisebenzayo kwi-Bunge).I-Astramembrangenin inokhuseleko lomlomo kwaye inoluhlu olubanzi lweempembelelo ze-pharmacological, kubandakanywa nokusebenza kwe-telomerase, i-telomere prolongation, i-anti-inflammatory kunye ne-antioxidant properties.I-Astramembrangenin ineempawu ezichasayo zokuguga.I-CAG ivuselela umsebenzi we-telomerase kwi-keratinocyte yabantu abasanda kuzalwa kunye neeseli zemithambo-luvo kwaye yenza ukuba kusebenze i-CREB.I-Astramembrangenin inokuba nefuthe elitsha lonyango kuxinzelelo
Iindidi ezifanelekileyo:
Indlela yokubonakalisa imiqondiso > > i-apoptosis > > i-apoptosis
Inkalo yophando > > ukudumba / ukunganyangeki
Inkalo yophando > > izifo ze-neurological
Isifundo se-In Vitro:
Xa kuthelekiswa nolawulo lomthwali kwinkcubeko ye-HEK, iprotheni ye-membrane yeenkwenkwezi (0-10 μ M; iintsuku ze-3-6) yanda ukukhula kweeseli [1].I-Astramembrangenin (0.3 μ M;I-5-90 imizuzu) yenza i-CREB phosphorylation kwi-neurons ye-cortical engundoqo, kunye nokubonakaliswa kwe-CREB iyonke kuzo zombini iindidi zeeseli ayizange ichaphazeleke yi-CAG [1].Iprotheni ye-membrane yeenkwenkwezi (3) μ M;Iiyure ze-6-48) zinokukhuthaza kwi-vivo ukuhanjiswa kwesignali kwii-neurons, ukwandisa ukubonakaliswa kwe-TERT mRNA, kunye nokubonisa ukwanda kwe-bcl 2 mRNA expression [1].Uvavanyo lokusebenza kweseli [1] umgca weseli: I-HEK yoxinaniso lweseli: 1 μ M, 3 μ M, 10 μ M ixesha lenkcubeko: iintsuku ezi-3-6 iziphumo: ukukhula kweeseli kuphindwe kabini kwiintsuku ze-6.Uhlalutyo lwe-blot yaseNtshona [1] umgca weseli: ugxininiso lweseli ye-neuron: 0.3 μ M ixesha lenkcubeko: imizuzu emi-5, imizuzu eyi-15, imizuzu engama-30, imizuzu engama-90.Iziphumo: I-CAG yenza ukuba i-CREB isebenze kwi-neurons.I-RT-PCR [1] umgca weseli: i-neuron cell concentration: 3 μ M ixesha lenkcubeko: iiyure ze-6-48 iziphumo: ukubonakaliswa kwe-TERT kunye ne-Bcl 2 mRNA kwanda.
Isalathiso:
[1].Ip FC, kunye nabanye.I-Cycloastragenol yinto enamandla ye-telomerase activator kwiiseli ze-neuronal: iimpembelelo kulawulo lokudakumba.Iisignali zemithambo-luvo.2014;22(1):52-63.
[2].UYu Y, et al.Cycloastragenol: Umgqatswa wenoveli onomdla wezifo ezinxulumene nobudala.Exp Ther Med.2018 Sep; 16 (3): 2175-2182.
[3].Sun C, et al.I-Cycloastragenol yenza kusebenze kunye nokunyanzeliswa kokwanda kwi-concanavalin A-induced mouse lymphocyte pan-activation model.Immunopharmacol Immunotoxicol.2017 Jun; 39 (3): 131-139.
IiPropati zePhysicochemical yeCycloastragenol
Ubuninzi:1.2 ± 0.1 g / cm3
Indawo yokubilisa:617.2 ± 55.0 ° C kwi-760 mmHg
Indawo yokunyibilika:241.0 ukuya ku-245.0 ° C
Ifomula yemolekyuli:c30h50o5
Ubunzima bemolekyuli:490.715
Indawo yokuflasha:327.1 ± 31.5 ° C
Ubunzima obuchanekileyo:490.365814
PSA:90.15000
I-LogP:3.82
Uxinzelelo lomphunga:0.0 ± 4.0 mmHg ku-25 ° C
Isalathiso seRefractive:1.582
Ulwazi ngoKhuseleko lweCycloastragenol
Ikhowudi yezothutho yempahla eyingozi: nonh kuzo zonke iindlela zothutho
inombolo ye-RTECS;GX8265000
Ikhowudi yeCustoms: 2942000000
Cycloastragalol Customs
Ikhowudi yeCustoms: 2942000000
Uncwadi lweCycloastragalol
I-Cycloastragenol yinto enamandla ye-telomerase activator kwiiseli ze-neuronal: iimpembelelo zokulawula uxinzelelo.
Ii-Neurosignals 22(1) , 52-63, (2014)
I-Cycloastragenol (CAG) yi-aglycone ye-astragaloside IV.Yaqala ukuchongwa xa kuhlolwa i-Astragalus membranaceus extracts yezithako ezisebenzayo ezineempawu zokuguga.Uphononongo lwangoku ...
Inoveli ye-telomerase activator icinezela umonakalo wemiphunga kwimodeli ye-murine ye-idiopathic pulmonary fibrosis.
PLoS ONE 8(3) , e58423, (2013)
Ukuvela kwezifo ezinxulumene nokungasebenzi kakuhle kwe-telomere, kubandakanya i-AIDS, i-aplastic anemia kunye ne-pulmonary fibrosis, kuye kwaqinisa umdla kwi-activators ye-telomerase.Sinika ingxelo ngokuchongwa kwen...
I-Telomerase-based pharmacologic yokuphucula umsebenzi we-antiviral we-CD8+ T lymphocytes yabantu.
J. Immunol.181(10), 7400-6, (2008)
I-Telomerase ibuyisela umva ikhuphela i-telomere DNA kwiziphelo zechromosomes kwaye ibambezela ukuguga kweeseli.Ngokwahlukileyo kwiiseli ezininzi eziqhelekileyo ze-somatic, ezibonisa umsebenzi omncinci okanye ongekhoyo we-telomerase, i-immun ...
Igama lesiNgesi leCycloastragalol
9,19-Cyclolanostane-3,6,16,25-tetrol,20,24-epoxy-,(3β,6α,9β,16β,20R,24S)-
Astramembrangenin
(3β,6α,9β,16β,20R,24R)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol
I-19-Cyclolanostane-3,6,16,25-tetrol,20,24-epoxy-,(3β,6α,9β,16β,20R,24R)-
(3β,6α,9β,16β,20R,24S)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol
Cyclosieversigenin
Cyclogalegegenin
