I-Dimethylfraxetin ;6,7,8-Trimethoxycoumarin
Ukucaciswa kweMveliso
Igama Eliqhelekileyo:uthuthu umthi element
Inombolo yeCAS:6035-49-0
Ubuninzi:1.2 ± 0.1 g / cm3
Ifomula yemolekyuli:C12H12O5
I-MSDS:N / A
Igama lesiNgesi:idimethylfraxetin
Ubunzima beMolekyuli:236.221
Indawo yokuBilisa:408.0 ± 45.0 ° C kwi-760 mmHg
Indawo yokunyibilika:104-105 º C
Indawo yokuflasha:184.3 ± 28.8 ° C
Umsebenzi webhayoloji we-dimethylfraxetin
Inkcazo:I-dimethylfraxetin yi-carbonic anhydrase inhibitor enexabiso le-Ki ye-0.0097 μ M.
Iindidi ezinxulumeneyo:
indlela yomqondiso > > i-enzyme ye-metabolic / iprotease > > i-carbonic anhydrase
Indawo yophando > > umhlaza
Iimveliso zendalo > > iiasidi ze-benzoic
Ekujoliswe kuko:ki: 0.0097 μ M (Carbonic anhydrase)[1]
Isifundo se-in vitro:kwi-CA I, enye i-compound evelele yi-dimethylfluoxetine (i-compound 17), i-nanomolar CA I inhibitor.Le trimethoxycoumarin yeyona isebenzayo kuyo nayiphi na i-NP coumarin phakathi kwe-CA isozymes ezintandathu kolu phononongo [1].
Kinase:Ngaphambi kokumiselwa, i-inhibitor (kubandakanywa ne-dimethylerythromycin) kunye nesisombululo se-enzyme sasifakwe ngaphambili kwiqondo lokushisa kwegumbi kwiiyure ze-6 ukuvumela ukusekwa kwe-enzyme inhibitor complex [1]
IiReferensi:[1] UDavis RA, et al.Imveliso yendalo ye-coumarins inqanda i-carbonic anhydrases yomntu.Bioorg Med Chem.2013 Mar 15;21(6):1539-43.
I-Dimethylfraxetin
Ubuninzi:1.2 ± 0.1 g / cm3
Indawo yokuBilisa:408.0 ± 45.0 ° C kwi-760 mmHg
Indawo yokunyibilika:104-105 º C
Ifomula yemolekyuli:c12h12o5
Ubunzima beMolekyuli:236.221
Indawo yokuflasha:184.3 ± 28.8 ° C
IMisa echanekileyo:236.068466
PSA:57.90000
LogP:1.75
Uxinzelelo lomphunga:0.0 ± 1.0 mmHg ku-25 ° C
Isalathiso seRefractive:1.545
Ulwazi loKhuseleko lweDimethylfraxetin
Ingxelo yomngcipheko (eYurophu): 22
Ingxelo yoKhuseleko (eYurophu):22-45
IKhowudi yeCustoms:293220990
I-Dimethylfraxetin ePhezulu kunye neeMveliso ezisezantsi
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I-Dimethylfraxetin Customs
IKhowudi yeCustoms:293220990
Isishwankathelo saseTshayina:293220990 Ezinye iilakthoni Umlinganiselo weVAT: 17.0% Izinga lesaphulelo serhafu: 13.0% Iimeko zolawulo: akukho nanye Uluhlu lweerhafu zeMFN: 6.5% Uluhlu lweerhafu ngokubanzi: 20.0%
Iimpawu zesibhengezo:igama lemveliso, ukwakheka, umxholo kunye nenjongo
Isishwankathelo:2932209090. ezinye lactones.IVAT:17.0%.Ireyithi yesaphulelo serhafu:13.0%..Intlawulo yeMFN:6.5%.Uluhlu lweerhafu ngokubanzi: 20.0%
Igama lesiNgesi leDimethylfraxetin
6,7,8-trimethoxychromen-2-enye
6,7,8-Trimethoxy-2H-chromen-2-enye
2H-1-Benzopyran-2-enye, 6,7,8-trimethoxy-
