Iimveliso

Inkcazo:I-glucoridin i-isoflavane esuka kwi-glycorrhiza glabra, enokuthi ibophe kwaye isebenze i-PPAR γ, Ixabiso le-EC50 yi-6115 nm.I-Glabridin ine-antioxidant, i-antibacterial, i-anti glomerulonephritis, i-anti-diabetes, i-anti-tumor, i-anti-inflammatory, i-anti osteoporosis, ikhusela i-cardiovascular, ikhusela imithambo-luvo, i-scavenge i-radicals yamahhala kunye neminye imisebenzi.

Iindidi ezinxulumeneyo:icandelo lophando > > umhlaza
Indlela yokubonisa > > umjikelo weseli / umonakalo weDNA > > PPAR
Inkalo yophando > > ukudumba / ukunganyangeki

Isifundo se-In Vitro:i-glabridin ibopha kwaye ivule i-PPAR γ, i-EC50 yi-6115 nm [1].I-Glabridin (40,80 μ M) Ukwanda kwe-SCC-9 kunye ne-SAS imigca yeseli yayithintelwe kwidosi kunye nexesha elixhomekeke kwindlela emva kwe-24 kunye ne-48 iiyure zonyango [2].I-Glabridin (0-80 μ M) Kwakhona yenza i-apoptosis, ekhokelela ekubanjweni komjikelo weseli ye-G1 kwi-SCC-9 kunye nemigca yeseli ye-SAS [2].I-Glabridin (i-0,20,40 kunye ne-80 μ M) I-dose isebenze ngokuxhomekeke kwi-Caspase-3, - 8 kunye - 9 kunye nokunyuka kwe-PARP cleavage, ngokuphawulekayo phosphorylating ERK1 / 2, JNK1 / 2 kunye ne-P-38 MAPK kwi-SCC-9.Iiseli [2].

KwiSifundo seVivo:I-glabridin (50 mg / kg, i-Po kanye yonke imihla) ibonise umsebenzi onamandla ochasayo kunye nokuphucula utshintsho oluvuthayo olubangelwa yi-dextran sodium sulfate (DSS) [3]

IiReferensi:[1] Rebhun JF, et al.Ukuchongwa kwe-glabridin njenge-bioactive compound kwi-licorice (i-Glycyrrhiza glabra L.) isicatshulwa esenza i-peroxisome proliferator-activated receptor gamma (PPAR γ) isebenze.IFitoterapia.2015 Okt;106:55-61 .
[2].Chen CT, et al.I-Glabridin yenza ukuba i-apoptosis kunye nokubanjwa kwe-cell cycle kubanjwe kwiiseli zomhlaza womlomo ngokusebenzisa i-JNK1 / 2 indlela yokubonisa.I-Environ Toxicol.2018 Jun;33(6):679-685.
[3].El-Ashmawy NE, et al.Ukunciphisa i-iNOS kunye nokuphakama kwe-camp kulungelelanisa umphumo wokuchasana nokuvuvukala kwe-glabridin kwiigundane ezine-ulcerative colitis.I-Inflammopharmacology.2018 Epreli;26(2):551-559.